The effect of exercise interventions on symptoms of anxiety in persons with multiple sclerosis: a systematic review and meta-analysis.

Introduction: Persons with multiple sclerosis (MS) frequently experience symptoms of anxiety. There is a large unmet need for effective and accessible interventions.

Objectives: To assess the effect of exercise on symptoms of anxiety in persons with MS, consider characteristics associated with effectiveness, and evaluate intervention design reporting.

Perturbation of the ovine placental transcriptome occurs at sub-therapeutic exposures to antenatal steroid therapy.

Introduction: Antenatal steroid (ANS) therapy accelerates preterm lung maturation. Clinical and experimental data show current regimens disrupt placental function and transport and impact fetal growth. We have previously shown that higher materno-fetal steroid exposures increase fetal glucocorticoid clearance.

Health Related Quality of Life and Sleep Regularity Among Middle-Aged to Older Adults From the Community.

Irregular sleep is increasingly related to poorer health, with stronger links to cardiovascular disease and mortality than sleep duration. Its impact on health-related quality of life, however, remains unclear, particularly in community-based populations. This study examined whether objectively measured sleep regularity is associated with physical and mental health-related quality of life.

Item selection for the development and validation of a revised classification criteria for adult and juvenile idiopathic inflammatory myopathies: MyoROC project.

Objective: A revision of the 2017 EULAR-ACR myositis classification criteria, namely EULAR-ACR funded Myositis Revision of Classification (MyoROC) project, is currently underway involving a large international group of experts. In the first phase of this project, we identified additional items to be tested in the criteria.

Methods: We distributed an electronic survey to International Myositis Assessment and Clinical Studies (IMACS) members to identify new items.

Harnessing 50 years of tick population genetics: Choosing the right molecular tool for contemporary research.

Ticks are ectoparasites of major medical, veterinary and ecological importance, transmitting a wide range of pathogens to humans, companion animals and livestock. Understanding the population structure of ticks is essential for uncovering patterns of pathogen transmission, and population genetics provides a powerful method for this purpose. Tick population studies are uniquely challenging as their biology is shaped by complex interactions between hosts, microbiome and environmental factors.

Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development.

Ovarian aging significantly contributes to the decline of the female reproductive system, adversely affecting fertility and endocrine homeostasis. To address the challenges posed by reproductive aging, natural products have shown promising preventive and therapeutic effects. Here, we investigated the beneficial effects of natural compound celastrol on ovarian development and aging, together with its underlying mechanisms.

RPS27L Enhances Myogenesis and Muscle Mass by Targeting IGF1 Through Liquid-Liquid Phase Separation.

RNA-binding proteins (RBPs) play a pivotal role in post-transcriptional regulation of gene expression, critically influencing skeletal myogenesis, muscle growth, and regeneration. Despite the recent identification of RBP Rps27l (ribosomal protein S27-like) as a regulator affecting myogenic proliferation and differentiation, its functions and regulatory mechanisms in skeletal muscle development remain largely unknown. In this study, it is observed that muscle-specific Rps27l knock-in (M─KI) mice exhibit significantly increased muscle mass, enlarged myofiber size, a higher proportion of fast-twitch myofibers, and enhanced muscle regeneration capabilities compared to wild-type controls.

Perfectionism, self-compassion, and general self-efficacy between those with and without chronic pain.

Although the association between stress and pain is recognised, little is known about links between chronic pain and stress arising from perfectionist expectations. Two studies compared levels of socially prescribed perfectionism (SPP), self-oriented perfectionism (SOP), self-compassion (SC), and self-efficacy (SE) between individuals with and without chronic pain. In Study 1, 237 participants with chronic pain and 237 without pain completed an online survey.

Stress physiology of scalloped and great hammerhead sharks from a bottom longline fishery.

The scalloped hammerhead and the great hammerhead are large, coastal to semi-oceanic shark species common to waters of the US east coast where they are regularly taken in commercial and recreational fisheries, particularly the bottom longline fishery. High rates of hooking mortality and low rates of population growth are believed to have caused severe declines in the US Atlantic populations of these species. The objective of this study was to determine the physiological stress induced by bottom longline capture in both and .

Integrating Serological and Genomic Data to Elucidate Lumpy Skin Disease Virus Diversity in Cattle from Bangladesh.

Lumpy skin disease virus (LSDV), a transboundary pathogen threatening cattle health in South and Southeast Asia, presents growing challenges for disease control. This study combined serological, molecular, and genomic approaches to investigate LSDV in Barura Upazila, Bangladesh. Serological screening of 424 cattle using a commercial ELISA revealed a high seroprevalence of 55.

Agreeing Language in Veterinary Endocrinology (ALIVE): Cushing's Syndrome and Hypoadrenocorticism-A Modified Delphi-Method-Based System to Create Consensus Definitions.

Progress in clinical practice, research, and teaching needs a common language. Agreement among veterinary endocrinologists on definitions of concepts related to Cushing's syndrome (CS) and hypoadrenocorticism is lacking. After a successful inaugural cycle on diabetes mellitus terminology, project Agreeing Language in Veterinary Endocrinology (ALIVE) held a second cycle, with simplified methodology, and brought together 10 experts of the European Society of Veterinary Endocrinology (ESVE) and the Society of Comparative Endocrinology (SCE).

Physicochemical and Sensory Properties of Davidson Plum () Sorbet, a Potential for New Functional Food Product.

The Australian native foods, despite high phytochemical composition, are severely underutilized in research and on the commercial market. One of these plants is the Davidson plum (), a nutrient-dense and sustainable food ingredient. The study aimed to develop functional fruit sorbets incorporating freeze-dried Davidson plum powder (0-20% /) and evaluate their physicochemical, antioxidant, and sensory properties.

Exploring Biological Evidence of Radioprotective Effects and Critical Oxygen Thresholds in (Diptera: Tephritidae).

Irradiation combined with Modified Atmosphere (MA) Packaging (MAP) is increasingly applied to disinfest fresh harvested produce while maintaining quality. However, anoxia and hypoxic conditions created by MA can reduce the effectiveness of ionizing radiation by inducing radioprotective effects in insects. This study investigated the relationship between oxygen levels and radiation efficacy in late third-instar larvae of .

Cannabidiol Enhances the Therapeutic Efficacy of Olsalazine and Cyclosporine in a Murine Model of Colitis.

Current therapies for inflammatory bowel disease (IBD), such as olsalazine and cyclosporine, often exhibit limited long-term efficacy and are associated with adverse effects. Cannabidiol (CBD), a non-psychoactive phytocannabinoid, shows promise for its anti-inflammatory properties, though its effectiveness as a monotherapy remains inconclusive. This study investigates the therapeutic potential of combining low-dose CBD (10 mg/kg) with olsalazine (50 mg/kg) or cyclosporine (2.

Chiropractic & Manual Therapies: a critical review of 20 years as an open-access journal.

Background: This study reviews the 20-year history (2005-2025) of Chiropractic & Manual Therapies as an open-access, peer-reviewed journal. Originally launched in 1992 as COMSIG Review, the journal has undergone multiple title changes and is currently financially supported by three chiropractic societies. This review critically examines 20 years (2005-2025) as an open-access online journal and makes recommendations for future growth.

Acute metabolite responses to swimming exercise of different intensities in highly trained male and female swimmers.

We investigated metabolite responses to different swimming intensities in 16 highly trained swimmers (9 males, 7 females, aged 16-24 years). After determining critical swimming speed (CS) with a 12 × 25 m maximal effort test, participants completed three swimming trials at moderate (below CS), heavy (at CS), and severe (above CS) intensities on separate days. Capillary blood samples (1 mL) were collected before and after each trial for metabolite profiling via mass spectrometry.

Feeding on Beauveria bassiana-treated Frankliniella occidentalis causes negative effects on the predatory mite Stratiolaelaps scimitus.

The soil-inhabiting predatory mite Stratiolaelaps scimitus (Womersley) (Acari: Laelapidae) and the entomopathogenic fungus Beauveria bassiana (Balsamo) Vuillemin (Hypocreales: Cordycipitaceae) can both serve as effective biocontrol agents against the pest Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae). Assuming the fungus B. bassiana does not adversely affect S.

Machine Learning-Guided Design of Biomass-Based Porous Carbon for Aqueous Symmetric Supercapacitors.

Biomass-derived porous carbon electrodes have attracted significant attention for high-performance supercapacitor applications due to their sustainability, cost-effectiveness, and tunable porosity. To accelerate the design and evaluation of these materials, it is essential to develop accurate and efficient strategies for optimizing their physicochemical and electrochemical properties. Herein, a machine learning (ML) approach is employed to analyze experimental data from previously reported sources, enabling the prediction of specific capacitance (F g) based on various material characteristics and processing conditions.

Prevalence of attention deficit hyperactivity disorder/hyperkinetic disorder of pediatric and adult populations in clinical settings: a systematic review, meta-analysis and meta-regression.

Background: Attention-Deficit/Hyperactivity Disorder (ADHD)/Hyperkinetic Disorder (HD) is linked to increased risks of morbidity, comorbidity and mortality, with higher prevalence in clinical populations. The differential prevalence of ADHD/HD across adult and pediatric clinical populations, influenced by factors such as time trends, sex, age, geographic regions, and comorbidities, has not been systematically assessed.

Methods: MEDLINE, CINAHL, Embase and PsycINFO databases were searched from inception to 1st August 2023 for eligible full-text papers published in English, and reviewing reference lists of identified studies and review papers.

Effectiveness of Kaolinite with and Without Polyaluminum Chloride (PAC) in Removing Toxic .

spp. blooms and paralytic shellfish poisoning pose serious economic threats to coastal communities and aquaculture. This study evaluated the removal efficiency of two strains using natural kaolinite clay (KNAC) and kaolinite with polyaluminum chloride (KPAC) at three concentrations (0.

Randomised controlled trial of a low plastic diet and lifestyle intervention for adults with cardiometabolic risk factors: the Plastic Exposure Reduction Transforms Health (PERTH) trial - a protocol.

Introduction: Phthalates and bisphenols, chemicals commonly used in the production of plastic products, exhibit endocrine disrupting properties linked to obesity and systemic inflammation. Given the ubiquitous use of plastic chemicals, their adverse impact on human health is of great importance. In this protocol, we describe a randomised controlled trial aimed at testing whether minimising exposure to plastics and plastic-associated chemicals (PACs) in community-dwelling adults with cardiometabolic risk factors can reduce urinary excretion of PACs and improve cardiometabolic health.

A chickpea MAGIC population to dissect the genetics of complex traits.

Multiparent populations are now widespread in crop genetic studies as they capture more genetic diversity and offer high statistical power for detecting quantitative trait loci (QTLs). To confirm the suitability of using a recently developed chickpea (Cicer arietinum L.) multi-parent advanced generation intercross (MAGIC) population for genetic studies, we characterized the diversity of the eight founder lines and explored the linkage disequilibrium decay, marker coverage, segregation distortion, allelic variation, and structure of the population.

Heterogeneity and distribution characteristics of tertiary lymphoid structures predict prognostic outcome in esophageal squamous cell carcinoma.

Objective: Tertiary Lymphoid Structures (TLSs) are ectopic lymphoid aggregates that form within the tumor microenvironment (TME) and are increasingly recognized as potential prognostic biomarkers in various cancers. However, the spatial heterogeneity and prognostic value of TLSs in esophageal squamous cell carcinoma (ESCC) remain poorly defined. This study aimed to characterize the spatial distribution patterns of TLSs and tumor-infiltrating lymphocytes (TILs), and to establish a refined prognostic model for ESCC patients in both surgery-only and neoadjuvant therapy cohorts.

What influences older people to join a community hub to engage in healthy ageing programs? An exploratory study.

Objectives: Most people seek to stay connected to their community as they age; this has been a major focus in the development of innovative community programs in Australia. This study aimed to explore what influences older people to join a community hub to engage in healthy ageing programs.

Methods: Semi-structured interviews (n = 29) were conducted during an Open Day in early 2023 at an urban community hub in Western Australia, followed by telephone interviews (n = 9) of a purposive sample of older individuals, community hub facilitators and coordinators of national community hubs.