Altered amyloid-β42 and BACE-1 proteins in plasma astrocyte-derived exosomes in hypertensive patients with cerebral microbleeds.

Background: Cerebral microbleeds (CMBs) have been found to promote Alzheimer's disease (AD) progression. Hypertension (HTN) is one of the major etiological factors for CMBs and an important risk factor for AD. However, the association between HTN-related CMBs and AD pathology remains undetermined.

Case Report: Tislelizumab-induced insulin-dependent diabetes mellitus: a case report and literature review.

Tislelizumab is approved for cancer immunotherapy. Tislelizumab-induced insulin-dependent diabetes mellitus (IDDM) is infrequent, but life-threatening; to date, no reports have been published in English. The study aims to analyze the adverse effect.

Impact of the first-pass pulmonary vein isolation on ablation outcomes in persistent atrial fibrillation.

Background: The achievement of first-pass isolation (FPI) during pulmonary vein isolation (PVI) generally serves as a reliable marker of lesion quality in initial radiofrequency encirclement and predicts favorable procedural outcomes. This study sought to evaluate the impact of the FPI on the long-term clinical outcomes in persistent atrial fibrillation (PeAF) patients undergoing radiofrequency ablation.

Methods: We conducted a retrospective analysis of 346 patients with PeAF who were divided into three groups: patients with FPI in bilateral PVs (BOTH group,  = 197), those with FPI in either ipsilateral PVs (EITHER group,  = 92), and those without FPI in bilateral PVs (NEITHER group,  = 57).

A Diamond-Based Neuromorphic Retina Perception System with Wide Spectrum Photoresponse and Wavelength Sensitivity.

Diamond, an important electronic and optoelectronic material, exhibits excellent performance in deep ultraviolet photodetection. However, its lack of visible light response and nonvolatile photocurrent hinders its application in neuromorphic sensors that mimic the human eye. In this work, we report a diamond-based neuromorphic retina perception system (NRPS) that demonstrates broad-spectrum photoresponse beyond the human visual range, nonvolatile photocurrent, and wavelength sensitivity.

Knowledge, attitudes, and practices towards aphasia among healthcare workers in Anhui, China: a cross-sectional survey.

Background: The information on knowledge, attitudes, and practices (KAP) related to aphasia among Chinese healthcare workers is scarce. This study aimed to assess the KAP related to aphasia among Chinese healthcare workers, and to identify associated sociodemographic factors.

Methods: An online cross-sectional survey was distributed to tertiary hospitals in Anhui Province, China.

E2F1-driven EXOSC10 transcription promotes hepatocellular carcinoma growth and stemness: a potential therapeutic target.

Background: E2F Transcription Factor 1 (E2F1) is a transcription factor that plays a crucial role in the growth of many cancers, including hepatocellular carcinoma (HCC). Herein, this study probed the functions and underlying mechanisms of E2F1 in HCC tumorigenesis.

Methods: The expression profiles of E2F1 and Exosome Component 10 (EXOSC10) were detected using qRT-PCR and western blotting.

Determination of Tigecycline in Plasma and Bronchoalveolar Lavage Fluid by UPLC-MS/MS and Its Application to a Pharmacokinetic Study in Critically Ill Patients.

Tigecycline has been widely used for treating infections caused by multidrug resistant bacteria, but the dosage and intrapulmonary distribution were still controversial. In this study, a UPLC-MS/MS method was established and fully validated to quantify tigecycline in human plasma and BALF. A simple and rapid protein precipitation was used to extract the analytes from plasma and BALF samples.

Suture Anchor and Reverse Suture Anchor Show Superior Biomechanical Efficacy to Transtibial Pull-Out Repair for Posterior Medial Meniscus Root Tears in Porcine Model.

Purpose: To investigate the biomechanical efficacy of the reverse suture anchor (RSA) technique compared with the transtibial pull-out (TP) and suture anchor (SA) techniques using in vitro porcine knee models of posterior medial meniscus root tear (PMMRTs).

Methods: A total of 32 fresh-frozen porcine tibiae with medial meniscus intact were randomly assigned to 4 groups (8 specimens each). A standardized PMMRT was established in 24 specimens.

MicroRNA-32-5p promotes the proliferation and metastasis of gastric cancer cells.

Gastric cancer (GC) is a huge threat to global health, there is no effective treatment or just delay the progression of advanced GC until now. Micro-RNAs were reported to participate in the progression of GC. Clonal formation, MTT, caspase-3 activity, sperm DNA fragmentation, flow cytometry assay, cell adhesion, transwell assays were performed to detect the functions of miR-32-5p or anti-miR-32-5p on the growth and metastasis of GC cells.

Secondary analysis reveals gut microbiota differences in patients with Parkinson's disease and/or cognitive impairment.

Parkinson's disease (PD) is a neurodegenerative disorder, and the main clinical characteristics are bradykinesia and muscle stiffness. Cognitive impairment (CI) is a prevalent non-motor manifestation observed in individuals with PD. According to disease severity, it can be divided into PD with mild cognitive impairment (MCI) and PD dementia.

Comparing ceftazidime/avibactam and polymyxin B for treating carbapenem-resistant organisms infections: A propensity score-matched retrospective cohort study.

Background And Aim: There are limited comparative studies of ceftazidime/avibactam (CAZ/AVI) vs. polymyxin B (PMB) for carbapenem-resistant organisms (CRO) infections. The aim of this study was to compare the efficacy and safety of CAZ/AVI and PMB in treating CRO infections.

Microsurgical obliteration of craniocervical junction dural arteriovenous fistulas via a suboccipital median approach: a retrospective study.

Objective: The authors report on a broad range of microsurgical procedures in which the suboccipital median technique was used to treat craniocervical junction arteriovenous fistulas. Their aim was to evaluate the efficacy of the suboccipital posteromedian approach and to assess the associated clinical outcomes.

Methods: The authors extracted information on the fistula site, clinical manifestation, and structural characteristics of arterial and venous vessels by retrospectively evaluating cases from a neurointerventional database spanning 10 years.

Strategy Optimization for a Combined Procedure in Patients With Atrial Fibrillation: The COMBINATION Randomized Clinical Trial.

Importance: The optimal strategy of combining left atrial appendage occlusion (LAAO) with catheter ablation (CA) in patients with atrial fibrillation (AF) during a single procedure remains unclear.

Objective: To determine the effects of ablation-first vs occlusion-first strategies on long-term clinical outcomes among patients with atrial fibrillation undergoing a combined LAAO and CA procedure.

Design, Setting, And Participants: The prospective, multicenter COMBINATION randomized clinical trial was conducted in 14 high-volume centers in China.

A simple HPLC-MS/MS method for the determination of polymyxin B in human plasma and its application in the pharmacokinetic study in elderly patients infected with multidrug-resistant Gram-negative bacteria.

Polymyxin B is widely used to treat infections caused by multidrug-resistant Gram-negative bacteria. However, the pharmacokinetic study data of PB in the elderly are scarce. Herein, a simple method to measure the concentration of PB in human plasma was developed and validated by high performance liquid chromatography-tandem mass spectrometry, and it was applied to a PK study in the elderly.

Comparative Effectiveness of Therapies in 2665 Elderly Patients with Ruptured Intracranial Aneurysms.

Background: The optimal treatment strategy for elderly patients with ruptured intracranial aneurysms (IAs) remains controversial. We evaluated a national, multihospital database to compare the outcomes of aggressive treatment and medical management for those patients.

Methods: We performed a retrospective analysis of 2665 elderly patients with ruptured IAs admitted to 11 hospitals in China.

Single modular flow-electrode capacitive deionization using modified Prussian blue analogues as cation intercalation electrode for continuous water desalination.

Ion back-diffusion hinders the practical application of conventional flow-electrode capacitive deionization (FCDI) under long-term operational conditions. To address this challenge, the present study integrated cation intercalation deionization (CID) with FCDI. A novel PFCDI-CID system was developed by utilizing a modified Prussian blue analogues owing to their enhanced rheological and electrochemical properties.

Evaluation of the Quality and Readability of Online Information about Alzheimer's Disease in China.

Background: With the increasing popularity of the internet, a growing number of patients and their companions are actively seeking health-related information online.

Objective: The aim of this study was to assess the quality and readability of online information about Alzheimer's disease (AD) in China.

Methods: A total of 263 qualified AD-related web pages from different businesses, governments, and hospitals were obtained.

Analysis of atypical glandular cells in ThinPrep Pap smear and follow-up histopathology.

Background: Diagnosing atypical glandular cells (AGC) is a significant challenge in cytomorphology.

Methods: A retrospective study was undertaken to assess the prevalence of AGC and the subsequent histological outcomes over 5 years at a single institution.

Results: A total of 159,649 ThinPrep Pap tests, including 395 cases of AGC, were retrieved, of which 330 AGC cases had follow-up histopathology.

Gastric Leiomyosarcoma in Post-Gastrointestinal Stromal Tumor Era: Revisit.

Primary gastric leiomyosarcoma is an exceptionally rare disease. This review covers 41 post-gastrointestinal stromal tumor (GIST) era gastric leiomyosarcoma cases that are supported by immunohistochemistry markers. Other spindle cell lesions are also excluded through histological and immunohistochemistry evaluations.

Comparative pharmacokinetics of polymyxin B in critically ill elderly patients with extensively drug-resistant gram-negative bacteria infections.

Elderly patients are more prone to develop acute kidney injury during infections and polymyxin B (PMB)-associated nephrotoxicity than young patients. The differential response to PMB between the elderly and young critically ill patients is unknown. We aimed to assess PMB exposure in elderly patients compared with young critically ill patients, and to determine the covariates of PMB pharmacokinetics in critically ill patients.

Decreased PDLIM1 expression in endothelial cells contributes to the development of intracranial aneurysm.

Introduction: Intracranial aneurysm (IA) is a common vascular enlargement that occurs in the wall of cerebral vessels and frequently leads to fatal subarachnoid hemorrhage. PDZ and LIM domain protein 1 (PDLIM1) is a cytoskeletal protein that functions as a platform for multiple protein complex formation. However, whether PDLIM is involved in the pathogenesis of IA remains poorly understood.

Orthostatic Hypotension Promotes the Progression From Mild Cognitive Impairment to Dementia in Type 2 Diabetes Mellitus.

Context: In type 2 diabetes mellitus (T2DM), orthostatic hypotension (OH) is associated with cognition, but the mechanisms governing the link between OH and cognition are still unclear.

Objective: We sought to analyze Alzheimer's disease (AD) biomarkers and the part of complement proteins in modulating the association of OH with cognitive impairment and examine whether OH could accelerate the clinical progression of mild cognitive impairment (MCI) to dementia in T2DM.

Methods: We recruited patients with T2DM with MCI and collected general healthy information and blood samples.

Primary Gastric Leiomyosarcoma: A Rare Case.

Gastric leiomyosarcoma is extremely rare. In this paper, we present a case of primary gastric leiomyosarcoma located in the fundus/cardia region. The tumoral spindle cells show diffusely moderate nuclear atypia, with focally marked atypia and rare mitotic figures.

The Landscape of Primary Gastric Leiomyosarcoma in Texas Population: Analysis of Texas Cancer Registry Data.

Introduction Primary gastric leiomyosarcoma is an extremely rare disease. There have been no previous studies regarding gastric leiomyosarcoma in the Texas population. Methods Anonymous data of gastric leiomyosarcoma from the Texas Cancer Registry (TCR) was used.

Deep-Orga: An improved deep learning-based lightweight model for intestinal organoid detection.

Problem: Organoids are 3D cultures that are commonly used for biological and medical research in vitro due to their functional and structural similarity to source organs. The development of organoids can be assessed by morphological tests. However, manual analysis of organoid morphology requires intensive labor from professionals and is prone to observer discrepancies.