Exosomal MicroRNAs as novel diagnostic biomarkers in head and neck cancer: a systematic evaluation and meta-analysis.

Background: Head and neck cancer ranks as the sixth most common malignant tumor globally, with the majority of patients detected at advanced stages. Consequently, this study assessed the clinical diagnostic efficiency of exosomal microRNAs (miRNAs) for head and neck malignancies by meta-analysis.

Methods: The pertinent literature about exosomal miRNAs for the diagnosis of head and neck cancer was retrieved from the Chinese full-text journal database, Wanfang database, Wipu database, and the databases of PubMed, Embase, and Web of Science, spanning from the inception of the databases to April 30, 2024.

Exosomal epidermal growth factor receptor is involved in HPV-16 E7-induced epithelial-mesenchymal transition of non-small cell lung cancer cells: A driver of signaling in vivo.

Our previous studies have demonstrated that human papillomavirus (HPV)-16 E7 oncoprotein promoted epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) cells. Moreover, recent studies have found that exosomes can mediate EMT of NSCLC cells and epidermal growth factor receptor (EGFR) is related to the progression of NSCLC. Here, we further investigated the role of exosomal EGFR in HPV-16 E7-induced EMT of NSCLC cells.