Development and validation of a LASSO-based predictive model for inadvertent hypothermia in ICU patients.

Objective: To develop a risk predictive model for inadvertent hypothermia (IH) in intensive care unit (ICU) patients and to validate the accuracy of the model.

Methods: The data was collected at the ICU of a tertiary hospital in Zunyi from November 2022 to June 2023 for model construction and internal validation. Data collected at the ICU of another tertiary hospital in Zunyi from July 2023 to December 2023 was used for external validation.

Glymphatic, Structural, and Cognitive Changes During Breast Cancer Chemotherapy: A Longitudinal MRI Study.

The glymphatic system maintains brain homeostasis through cerebrospinal fluid transport and waste clearance. Its potential involvement in chemotherapy-related cognitive impairment remains largely unexplored due to limited in vivo evidence. In this prospective longitudinal study, 126 female breast cancer patients underwent multiparametric brain MRI and neuropsychological assessments at three time points: baseline (bc1), after the first cycle of neoadjuvant chemotherapy (bc2), and upon completion of neoadjuvant chemotherapy (bc3).

A comparison of three whitening protocols for mild-to-moderate dental fluorosis in anterior teeth.

Objective: This research compares the effectiveness of three whitening treatments for mild-to-moderate dental fluorosis in the front teeth.

Method: This retrospective study analysis is based on 51 mild-to-moderate dental fluorosis cases. The patients who visited the Dental Hospital of Ningxia Medical University from August 2020 to August 2021 were enrolled as research cases.

Ionic Conductive Binder Based on Fast Ion Conductor Interface Compatibilization for Lithium-Sulfur Batteries.

Binders are the key components for maintaining the integrity of sulfur electrodes in lithium-sulfur batteries. However, the traditional insulating binders have a negative impact on the charge transfer within the electrodes, which is an important factor leading to the poor rate performance of lithium-sulfur batteries. Herein, an ionic conductive binder (LPABM-d-LATP) based on the interface compatibilization of fast ionic conductor is synthesized by in situ emulsion polymerization and lithiation neutralization.

Conformalized Graph Learning for Molecular ADMET Property Prediction and Reliable Uncertainty Quantification.

Drug discovery and development is a complex and costly process, with a substantial portion of the expense dedicated to characterizing the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of new drug candidates. While the advent of deep learning and molecular graph neural networks (GNNs) has significantly enhanced in silico ADMET prediction capabilities, reliably quantifying prediction uncertainty remains a critical challenge. The performance of GNNs is influenced by both the volume and the quality of the data.

Iron overload regulates cognitive function in rats with minimal hepatic encephalopathy by inducing an increase in frontal butyrylcholinesterase activity.

Background And Aims: This study aimed to investigate the effect of iron overload on acetylcholinesterase activity in the frontal lobe tissue of rats with minimal hepatic encephalopathy (MHE) and its relation to cognitive ability. By elucidating the potential mechanisms of cognitive impairment, this study may offer insights into novel therapeutic targets for MHE.

Materials And Methods: Twelve Sprague-Dawley rats were purchased and randomly assigned to either the experimental or control group with six rats in each group.

Urban resilience reduces depressive symptoms among middle-aged and elderly adults: A multidimensional analysis based on China longitudinal healthy longevity survey.

With the rapid urbanization and aging population, depression has become a severe public health issue globally, affecting millions of individuals and significantly impacting their quality of life and healthcare costs. Urban resilience refers to a city's ability to absorb, recover, and prepare for future shocks, ensuring sustainable development despite challenges. This study aims to explore the impact of urban resilience on depressive symptoms among middle-aged and elderly adults.

Noise-Adaptive State Estimators with Change-Point Detection.

Aiming at tracking sharply maneuvering targets, this paper develops novel variational adaptive state estimators for joint target state and process noise parameter estimation for a class of linear state-space models with abruptly changing parameters. By combining variational inference with change-point detection in an online Bayesian fashion, two adaptive estimators-a change-point-based adaptive Kalman filter (CPAKF) and a change-point-based adaptive Kalman smoother (CPAKS)-are proposed in a recursive detection and estimation process. In each iteration, the run-length probability of the current maneuver mode is first calculated, and then the joint posterior of the target state and process noise parameter conditioned on the run length is approximated by variational inference.

A Conductive Binder Based on Mesoscopic Interpenetration with Polysulfides Capturing Skeleton and Redox Intermediates Network for Lithium Sulfur Batteries.

The practical application of lithium-sulfur batteries with high theoretical energy density and readily available cathode active materials is hampered by problems such as sulfur insulation, dramatic volume changes, and polysulfide shuttling. The targeted development of novel binders is the most industrialized solution to the problem of sulfur cathodes. Herein, an aqueous conductive emulsion binder with the sulfonate-containing hard elastic copolymer core and the conjugate polymer shell, which is capable of forming a bicontinuous mesoscopic interpenetrating polymer network, is synthesized and investigated.

Effects of physical activity on infertility in reproductive females.

Objectives: To explore the relationship between different types of physical activity and female infertility.

Methods: This study analyzed data from 2,796 female participants aged 18-44 years in the United States, obtained from the National Health and Nutrition Examination Survey (NHANES) database spanning the years 2013 to 2020. Multiple logistic regression analyses and generalized linear models were used to explore the relationship between different types of physical activity and infertility after adjusting for potential confounding factors.

Effects of culture temperature and light regimes on biomass and lipid accumulation of Chlamydomonas reinhardtii under carbon-rich and nitrogen-limited conditions.

This study investigated the impacts of various culture temperatures and light regimes on growth and biochemical constituents of Chlamydomonas reinhardtii under carbon-supply and nitrogen-limited conditions to improve oil production in algal cells. Results displayed that under a 30 ℃ and 150 μE/m/s regime, there was a significant increase in biomass, total lipids, and lipid productivity. Specifically, these parameters reached 1.

Crystal structure of an aspartate aminotransferase Lpg0070 from Legionella pneumophila.

Legionella pneumophila aspartate aminotransferase (Lpg0070) is a member of the transaminase and belongs to the pyridoxal 5'-phosphate (PLP)-dependent superfamily. It is responsible for the transfer of α-amino between aspartate and α-ketoglutarate to form glutamate and oxaloacetate. Here, we report the crystal structure of Lpg0070 at the resolution of 2.

Narrative medicine in clinical internship teaching practice.

To explore the effect on empathy skills of integrating narrative medicine instruction into clinical internship undergraduate medical education. One hundred clinical undergraduate students who were transferred to gynecology and obstetrics in 2016 were selected as subjects and divided into two groups. The control group adopted the traditional practice teaching mode, while the experimental group adopted a narrative medicine integrated with traditional teaching mode.

CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma mouse model through ROCK1-CAL signaling pathway.

The downregulation of adhesion molecule catenin alpha-like 1 (CTNNAL1) in airway epithelial cells of asthma patients and house dust mite (HDM)-induced asthma animal models was illustrated in our previous study. It is assumed to contribute to airway inflammation and mucus hypersecretion. In this work, we further explore the underlying mechanism of CTNNAL1 in asthma.

Recombinant-luteinzing hormone supplementation in women during IVF/ICSI cycles with GNRH-antagonist protocol: A systematic review and meta-analysis.

The objective of this meta-analysis is to determine the beneficial effect of recombinant-luteinizing Hormone (r-LH) addition in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with gonadotropin-releasing hormone (GnRH) antagonist protocol and whether an optimal time of Recombinant-Luteinizing Hormone (r-LH) supplementation exist during the controlled of stimulation (COS). The primary outcomes are clinical Pregnancy rate and the number of oocytes retrieved. Secondary outcomes are the number of metaphase II oocytes, miscarriage rate and live birth rate.

Pancancer analysis of SKA1 mutation and its association with the diagnosis and prognosis of human cancers.

This study aims to explore the role of SKA1 in cancer diagnosis and prognosis and to investigate the mechanism by which SKA1 affects the malignant behaviors of ovarian cancer. Herein, we analyzed the oncogenic role of SKA1 at pan-cancer level by multiple informatics databases and verified the analysis by in vitro experiments. As a result, SKA1 was upregulated across cancers and was related to poor clinical outcome and immune infiltration.

Identification of KCNK1 as a potential prognostic biomarker and therapeutic target of breast cancer.

Background: Breast cancer is the most common malignant cancer and is the second most common cause of cancer-related deaths among females worldwide. Thus, it warrants the urgent development of new therapeutic targets and strategies. Potassium channels are aberrantly expressed in various tumors and are related to tumor progression.

Maternal Hypercholesterolemia May Involve in Preterm Birth.

Maternal hypercholesterolemia during pregnancy is associated with an increased risk of preterm birth which is defined as <37 weeks of complete gestation. However, the underlying mechanism for the association between hypercholesterolemia and preterm birth is not fully understood. Macrophage, as one of the largest cell types in the placenta, plays a very critical role in mediating inflammation and triggers labor initiation.

Multi-Omics Analysis of MCM2 as a Promising Biomarker in Pan-Cancer.

Minichromosome maintenance 2 (MCM2) is a member of the minichromosomal maintenance family of proteins that mainly regulates DNA replication and the cell cycle and is involved in regulating cancer cell proliferation in various cancers. Previous studies have reported that MCM2 plays a pivotal role in cell proliferation and cancer development. However, few articles have systematically reported the pathogenic roles of MCM2 across cancers.

Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity.

The decline of nicotinamide adenine dinucleotide (NAD) occurs in a variety of human pathologies including neurodegeneration. NAD-boosting agents can provide neuroprotective benefits. Here, we report the discovery and development of a class of potent activators (NATs) of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD salvage pathway.

Optimization of NAMPT activators to achieve in vivo neuroprotective efficacy.

NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the treatment of many diseases associated with NAD exhaustion such as neurodegenerative diseases. Herein, we present the systematic optimization of NAT, an initial hit of NAMPT activator discovered by us through high-throughput screening, based on the co-crystal structure of the NAMPT-NAT complex. Over 80 NAT derivatives have been designed and synthesized, among which compound 72 showed notably improved potency as NAMPT activator and effectively protected cultured cells from FK866-mediated toxicity.

Systematic review and meta-analysis: the effectiveness and safety of acupuncture in the treatment of herpes zoster.

Background: The treatment of herpes zoster (HZ) by the traditional Chinese medicine of acupuncture is attracting attention. However, there is still a controversy about the effectiveness and safety of acupuncture treatment of HZ.

Methods: Articles on randomized controlled trials examining acupuncture and Western medicine treatments of HZ published since the establishment of the PubMed, Embase, Medline, and Chinese Biomedical Literature (CBM) databases to March 2021 were electronically retrieved.