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Article Abstract
Background And Aim: Type 1 diabetes mellitus (T1DM) is an autoimmune disease, which has a heavy disease burden and seriously affects the reproductive health of women of reproductive age. Therefore, this study assessed the disease burden of T1DM among women of reproductive age worldwide.
Methods And Results: This study extracted the incidence, prevalence, disability adjusted life years (DALYs) and deaths data of T1DM in women of reproductive age from the Global Burden of Disease (GBD) database from 1990 to 2021. The percentage change and the Estimated Annual Percentage Change were used to assess the change trend of T1DM burden in women of reproductive age, and the Bayesian Age-Period-Cohort model was used to predict the future disease burden. Compared to 1990, global incidence, prevalence, DALYs, and deaths cases of T1DM among women of reproductive age had significantly increased in 2021. The global age-standardized incidence rate (ASIR) and age-standardized prevalence rate (ASPR) rose, while age-standardized DALY rate (ASDR) and age-standardized mortality rates (ASMR) declined. High socio-demographic index (SDI) areas had higher ASIR and ASPR, and lower SDI regions had higher ASDR and ASMR. Younger age groups had higher ASIR, and elder age groups had higher ASPR, ASDR, and ASMR. By 2040, the burden is expected to further increase.
Conclusions: In general, from 1990 to 2021, the global burden of T1DM among women of reproductive age significantly increased, especially the rising incidence and prevalence rates, highlighting the need for enhanced management and treatment.
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