Soy isoflavones improve sympathetic nervous system-driven non-alcoholic fatty liver disease through estrogen-like effects.

This study investigated the advantages of gerbils as a sympathetic nervous system (SNS)-driven model for non-alcoholic fatty liver disease (NAFLD) and evaluated the therapeutic potential of soy isoflavones (SIFs). Gerbils exhibited unique SNS characteristics, with an adrenal gland-to-kidney weight ratio 2-3 times higher than that of C57BL/6 mice and Wistar rats, demonstrating elevated levels of adrenaline (AE) and noradrenaline (NE) as well as more pronounced anxiety-like behaviors, indicating enhanced SNS activity. Additionally, gerbils possessed liver lipid metabolism and storage capacities similar to humans, along with a simple genetic background, allowing them to more accurately reflect the pathogenesis of NAFLD.

MnO nanozymes as potential therapeutic agents for autism spectrum disorder: insights from behavioral and molecular studies.

: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder of uncertain etiology. Current studies suggest that ASD progression is closely linked to an imbalance between oxidative stress and antioxidant capacity, marked by elevated levels of reactive oxygen species (ROS) and reduced concentrations of antioxidant molecules such as superoxide dismutase (SOD) and glutathione (GSH). Although the human body does possess endogenous ROS-scavenging enzymes, their sensitivity to environmental conditions and the difficulties of large-scale production limit their practical application.

Acid Sites Cleavage of Surface-Frustrated Lewis Pairs for Small-Molecule Activation of Mixed Volatile Pollutants.

Exploring a new catalytic system to achieve the efficient photocatalytic oxidation of mixed volatile organic compounds (VOCs) is imperative. In this study, an in situ-designed surface-frustrated Lewis pair (SFLPs), coupled with the cleavage of the Lewis acid sites (LAs), effectively activated and mineralized a mixture of toluene (CH) and acetone (CHO). The precise functionalization facilitated by cleaved LAs achieves targeted activation of C-C bonds in CH and central phenyl methyl intermediates, as well as the carbonyl group (C═O) in CHO, via electron cloud polarization and orbital interactions.

PET-guided attention for prediction of microvascular invasion in preoperative hepatocellular carcinoma on PET/CT.

Purpose: To achieve PET/CT-based preoperative prediction of microvascular invasion in hepatocellular carcinoma by combining the advantages of PET and CT.

Methods: This retrospective study included a total of 100 patients from two institutions who underwent PET/CT imaging. The above patients were divided into a training cohort (n = 70) and a validation cohort (n = 30).

Prediction of placenta accreta spectrum by combining deep learning and radiomics using T2WI: a multicenter study.

Purpose: To achieve prenatal prediction of placenta accreta spectrum (PAS) by combining clinical model, radiomics model, and deep learning model using T2-weighted images (T2WI), and to objectively evaluate the performance of the prediction through multicenter validation.

Methods: A total of 407 pregnant women from two centers undergoing preoperative magnetic resonance imaging (MRI) were retrospectively recruited. The patients from institution I were divided into a training cohort (n = 298) and a validation cohort (n = 75), while patients from institution II served as the external test cohort (n = 34).