98%
921
2 minutes
20
The risk prediction of paroxysmal atrial fibrillation (PAF) is a challenge in the field of biomedical engineering. This study integrated the advantages of machine learning feature engineering and end-to-end modeling of deep learning to propose a PAF risk prediction method based on multimodal feature fusion. Additionally, the study utilized four different feature selection methods and Pearson correlation analysis to determine the optimal multimodal feature set, and employed random forest for PAF risk assessment. The proposed method achieved accuracy of (92.3 ± 2.1)% and F1 score of (91.6 ± 2.9)% in a public dataset. In a clinical dataset, it achieved accuracy of (91.4 ± 2.0)% and F1 score of (90.8 ± 2.4)%. The method demonstrates generalization across multi-center datasets and holds promising clinical application prospects.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955324 | PMC |
http://dx.doi.org/10.7507/1001-5515.202403039 | DOI Listing |
Nanoscale
September 2025
Institute of Health Innovation & Technology, National University of Singapore, Singapore, 117599, Singapore.
The rapid increase in multidrug-resistant (MDR) bacteria and biofilm-associated infections has intensified the global need for innovative antimicrobial strategies. Phage therapy offers promising precision against MDR pathogens by utilizing the natural ability of phages to specifically infect and lyse bacteria. However, their clinical application is hampered by challenges such as narrow host range, immune clearance and limited efficacy within biofilms.
View Article and Find Full Text PDFJ Immunother Cancer
September 2025
CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China
Neoadjuvant immunochemotherapy (nICT) has demonstrated significant potential in improving pathological response rates and survival outcomes for patients with locally advanced esophageal squamous cell carcinoma (ESCC). However, substantial interindividual variability in therapeutic outcomes highlights the urgent need for more precise predictive tools to guide clinical decision-making. Traditional biomarkers remain limited in both predictive performance and clinical feasibility.
View Article and Find Full Text PDFObjectives: To investigate whether quantitative retinal markers, derived from multimodal retinal imaging, are associated with increased risk of mortality among individuals with proliferative diabetic retinopathy (PDR), the most severe form of diabetic retinopathy.
Design: Longitudinal retrospective cohort analysis.
Setting: This study was nested within the AlzEye cohort, which links longitudinal multimodal retinal imaging data routinely collected from a large tertiary ophthalmic institution in London, UK, with nationally held hospital admissions data across England.
Stem Cell Reports
September 2025
Department of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy. Electronic address:
Human brain organoids, generated from pluripotent stem cells, recapitulate fundamental features of human brain development, including neuronal diversity, regional architecture, and functional network activity. Integrated multimodal and transcriptomic analyses reveal a molecular repertoire of ionotropic receptors supporting action potentials, synaptic transmission, and oscillatory dynamics resembling early brain activity. This review synthesizes current knowledge on the molecular and electrophysiological determinants of neuronal maturation and network computations, from synaptic integration to large-scale dynamics.
View Article and Find Full Text PDFComput Methods Programs Biomed
September 2025
Key Laboratory of Social Computing and Cognitive Intelligence (Ministry of Education), Dalian University of Technology, Dalian, 116024, China; School of Computer Science and Technology, Dalian University of Technology, Dalian, 116024, China. Electronic address:
Background And Objective: Few-shot learning has emerged as a key technological solution to address challenges such as limited data and the difficulty of acquiring annotations in medical image classification. However, relying solely on a single image modality is insufficient to capture conceptual categories. Therefore, medical image classification requires a comprehensive approach to capture conceptual category information that aids in the interpretation of image content.
View Article and Find Full Text PDF