[Effects and mechanisms of Yuxuebi Tablets combined with ibuprofen in treating chronic musculoskeletal pain through "integrated regulation of inflammation and pain-related oxylipins"].

This study adopted a three-dimensional "effect-dose-mechanism" evaluation system to screen the optimal regimen of Yuxuebi Tablets(YXB) combined with ibuprofen(IBU) for chronic musculoskeletal pain(CMP) intervention and elucidate its pharmacological mechanism, so as to provide a scientific basis for the clinical application of the regimen. The experiments were conducted using 8-week-old ICR mice, which were randomly divided into sham operation(sham) group, model(CFA) group, IBU group, YXB group, stasis paralysis tablets combined with ibuprofen low-dose group(IBU-L-YXB), stasis paralysis combined with ibuprofen high-dose group(IBU-H-YXB), stasis paralysis tablets combined with ibuprofen high-dose with ibuprofen discontinuation on the 10th day of administration(IBU-10-YXB), and stasis paralysis tablets combined with ibuprofen high-dose with ibuprofen halving on the 10th day of administration(IBU-1/2-YXB) group. An animal model was established using the CFA plantar injection method.

Glycosidic acids with α-glucosidase inhibitory activity as the alkaline hydrolysis products of resin glycoside fractions from Convolvulus tricolor and Ipomoea biflora.

Alkaline hydrolysis of the resin glycoside fractions of Convolvulus tricolor and Ipomoea biflora yielded three glycosidic acids (1-3). Contrilic acid A (1), a hexasaccharide glycosidic acid with a 3S,11S-dihydroxytetradecanoic acid as the aglycone, was isolated from Convolvulus tricolor, while a tetrasaccharide ipomofic acid A (2) and pentasaccharide operculinic acid A (3) were obtained from Ipomoea biflora, and were identified to possess a 11S-hydroxyhexadecanoic acid as the aglycone. Their structures were thoroughly established by the spectroscopic data and chemical evidences.

A STAT1-GBP3-STING positive feedback loop governs inflammation, oxidative stress, and DNA damage to trigger acute aortic dissection.

Acute aortic dissection (AAD) is a degenerative aortic remodeling disease characterized by exceedingly high mortality without effective pharmacologic therapies. Although oxidative stress, DNA damage, and inflammation are associated with AAD, the precise interplay among these responses has remained unclear. In this study, aortas from mouse AD models were subjected to integrative ATAC-seq and RNA-seq analysis.

Further new resin glycosides from Convolvulus tricolor seeds and their neuroprotective activities.

Resin glycosides, the characteristic constituents of family Convolvulaceae, are a kind of new and complex glycolipids with diversified biological activities. In the present study, the ethanolic extract of Convolvulus tricolor seeds were purified by various separation methods, leading to the isolation of seven new resin glycosides (1-7). Their structures were established as glycosidic acids methyl esters by extensive spectroscopic analyses and chemical evidences, and were considered to be generated via methyl esterification of natural resin glycosides during the NH silica gel chromatography.

Correlation of non-esterified fatty acids with acute coronary syndrome risk in young Chinese adults.

Objective: Circulating non-esterified fatty acids (NEFAs) are linked to endothelial dysfunction and coronary artery disease (CAD) mainly in older adults. This study examines the association between NEFAs and acute coronary syndrome (ACS) risk in young Chinese individuals.

Method: Of the 1264 young ACS patients and 1072 age-matched controls aged 55 years or younger assessed, 1108 ACS patients and 979 controls were found eligible.

Isolation of pentasaccharide resin glycosides from the whole plants of Ipomoea biflora and their cytotoxic activities.

A total of eight previously undescribed pentasaccharide resin glycosides, named ipomofins I-VIII (1-8), along with five known ones (9-13), were isolated from the whole plants of Ipomoea biflora. Their structural elucidation was achieved through a comprehensive application of spectroscopic and chemical techniques. All these resin glycosides were characterized as partially acylated pentasaccharides, originating from operculinic acids A or D, containing l-rhamnose, d-glucose, d-xylose or d-fucose units, and 11S-hydroxyhexadecanoic acid serving as the aglycone.

[Effect of Yuxuebi Tablets on mice with inflammatory pain based on GPR37-mediated inflammation resolution].

In order to investigate whether the effect of Yuxuebi Tablets on the peripheral and central inflammation resolution of mice with inflammatory pain is related to their regulation of G protein-coupled receptor 37(GPR37), an inflammatory pain model was established by injecting complete Freund's adjuvant(CFA) into the paws of mice, with a sham-operated group receiving a similar volume of normal saline. The mice were assigned randomly to the sham-operated group, model group, ibuprofen group(91 mg·kg~(-1)), and low-, medium-, and high-dose groups of Yuxuebi Tablets(60, 120, and 240 mg·kg~(-1)). The drug was administered orally from days 1 to 19 after modeling.

Controlins I-X, Resin Glycosides from the Seeds of and Their Biological Activities.

Ten new resin glycosides, controlins I-X (-), were isolated from the seeds of . Their structures were established by spectroscopic analysis as well as by chemical means. Compounds were identified as glycosidic acid methyl esters, considered as artifacts generated via transesterification with MeOH from natural resin glycosides.

Dynamic Metabolic Characterization of Lung Tissues in Rats Exposed to Whole-Thorax Irradiation Based on GC-MS.

An animal model of radiation-induced lung injury (RILI) was established using female rats given sublethal whole-thorax X-ray irradiation (15 Gy) at a dose rate of 2.7 Gy/min. The rats were studied for up to day 45 and compared with sham-irradiated controls.

[Interventional effect and inflammatory regulation mechanism of dihydroartemisinin combined with pregabalin on neuropathic pain mice].

This study aims to clarify the effects of dihydroartemisinin(DHA) combined with pregabalin(PGB) on neuropathic pain(NP) in mice and explore the neuroinflammatory regulatory mechanism. NP mice model was established using spinal nerve ligation, whereas the sham group exposed the spinal nerve without ligation. The mice were randomly divided into sham group, model group, PGB groups of low, medium, and high doses(PGB-L, PGB-M, and PGB-H, with 22, 45, and 91 mg·kg~(-1)), DHA group(16 mg·kg~(-1)), and DHA combined with PGB groups of low, medium, and high doses(DHA + PGB-L, DHA + PGB-M, and DHA + PGB-H).

Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte Ratio (MLR), and Eosinophil-to-Lymphocyte Ratio (ELR) as Biomarkers in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD).

Purpose: The study comprehensively evaluated the prognostic roles of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR), and eosinophil-to-lymphocyte ratio (ELR) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

Patients And Methods: Six hundred and nineteen patients with AECOPD and 300 healthy volunteers were retrospectively included into the study. The clinical characteristics of the patients with AECOPD and the complete blood counts (CBCs) of the healthy volunteers were collected.

The tenure track employment system in colleges and universities in China: a scoping review of the Chinese literature.

Chinese higher education institutions have adopted a US-style tenure track system since the 1990s. This is an important reform aimed at modernizing China's higher education system. In response, authors have begun to carry out close examination of the career system and analyse its implications in a national context (Republic of China).

Biotransformation of Ursonic Acid by and to Discover Anti-Neuroinflammatory Derivatives.

Biotransformation of ursonic acid () by two fungal strains CGMCC 3.5324 and CGMCC 3.407 yielded thirteen new compounds (, , -, and -), along with five recognized ones.

Improved emission performance of benzo[]phenoxazine in aqueous solution through host-guest interaction.

To evaluate the contribution of host-guest chemistry in fluorescence enhancement under aqueous conditions, two benzo[]phenoxazine derivatives with the adamantyl group were prepared. After they formed stable complexes with methyl-β-cyclodextrin, their emissions at 625-825 nm were greatly increased and fluorescence quantum yields reached 11.5-12.

α-Glucosidase inhibitors from the husks of rice Oryza sativa L.

Rice husk is one of the most plentiful agriculture by-products in rice producing areas, which harbors a substantial proportion of biological metabolites, however, it has not been well studied. As an attempt to utilize it as a productive manner, phytochemical investigation on rice husk has performed and led to the isolation of three undescribed (1, 2, and 7), along with twelve known components (3-6, and 8-15). Those chemical structures were elucidated based on massive spectroscopic methods.

[Study on mechanisms of acupuncture underlying improvement of CUMS-induced depression in rats based on tandem mass spectrometry proteomics technique].

Objective: To investigate the possible mechanism of "regulating qi and relieving depression" acupuncture underlying improvement of chronic unpredictable mild stress (CUMS)-induced depression in rats by using Tandem Mass Tags(TMT) quantitative proteomics technique.

Methods: Thirty-six male SD rats were randomly divided into control, model and acupuncture groups, with 12 rats in each group. The depression model was induced by CUMS stress for 21 days.

[Three-dimensional gingival morphology in the aesthetic zone of maxillary anterior teeth: a cone-beam CT analysis].

Purpose: To measure and investigate the relationship of three-dimensional gingival morphology on the labial side of the maxillary anterior teeth by using cone-beam CT(CBCT) in conjunction with a novel radiocontrast agent.

Methods: Thirty periodontal healthy subjects were enrolled. The composition of light-cured gingival barrier resin and iohexol injection was applied to the measurement area, then a positioning wire was set up, and CBCT was used to assess supracrestal gingiva tissue (SGT), gingiva thickness (GT) and width of keratinized gingiva (KGW).

Generation of sub-5 nm AuNPs in the special space of the loop-cluster corona of a polymer vesicle: preparation and its unique catalytic performance in the reduction of 4-nitrophenol.

The hybrid vesicle AuNP@LCCV, in which a large number of AuNPs with an average size of about 2.8 nm were densely and uniformly distributed in an isolated state throughout the corona of the unusual polymer vesicle, was prepared reduction of Au ions, which were encapsulated in advance in the unique polymer vesicle (LCCV) consisting of a hydrophobic membrane of poly(2-phenyl-2-oxazoline) and a hydrophilic loop-cluster corona of polyethyleneimine. The vesicle was formed self-assembly from a comb-like block copolymer in which a polystyrenic main chain was grafted densely with diblock polyethyleneimine--poly(2-phenyl-2-oxazoline) and acted as a reactor for the reduction of Au.

Thickness effects of polyethylene and biodegradable film residuals on soil properties and dryland maize productivity.

Plastic film residuals are increasingly remaining in cultivated lands. However, it is a critical issue how residual plastic type and thickness affect soil properties and crop yield. To address this issue, in situ landfill was conducted using thick polyethylene (PEt1), thin polyethylene (PEt2), thick biodegradable (BIOt1), thin biodegradable (BIOt2) residues, and CK (control) with no residues landfill in a semiarid maize field.

Bioactive Dimeric Diterpenoids from Taiwania cryptomerioides (Hayata) and Their Biological Activities.

Taiwania cryptomerioides Hayata is an endangered relict plant belonging to Taxodiaceae, and it is also an endemic plant to China. The decay-resistant of Taiwania timber can provide highly quality wood for building and furniture. Plenty of regenerative of leaves of T.

[Pricking-cupping therapy for cervical spondylotic radiculopathy with stagnation and blood stasis based on Young's modulus value].

Objective: To compare the clinical effect between pricking-cupping therapy and acupuncture-cupping therapy on cervical spondylotic radiculopathy (CSR) with stagnation and blood stasis, and to evaluate the trapezius muscle objectively and quantitatively with ultrasonic shear wave elastography (SWE).

Methods: A total of 70 patients with CSR of stagnation and blood stasis were randomly divided into a pricking-cupping group (35 cases) and an acupuncture-cupping group (35 cases). In both groups, Dazhui (GV 14), Jianjing (GB 21), C-C Jiaji (EX-B 2), positive sensitive points, etc.

17β-estradiol reduces NF-κB expression induced by increased crosstalk between KLF5 and ERα in murine vascular smooth muscle cells.

Pathological vascular remodeling and cell proliferation play vital roles in many proliferative vascular diseases. Estrogen can protect the cardiovascular system, but its exact molecular mechanism is unknown. Here we report that 17β-estradiol (E2) suppressed vascular smooth muscle cells (VSMCs) proliferation and inflammation.