Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Ten new resin glycosides, controlins I-X (-), were isolated from the seeds of . Their structures were established by spectroscopic analysis as well as by chemical means. Compounds were identified as glycosidic acid methyl esters, considered as artifacts generated via transesterification with MeOH from natural resin glycosides. Compound is the first nonasaccharide resin glycoside, while compounds - are rare octasaccharide resin glycosides. Compounds , , and could inhibit the nitric oxide production in lipopolysaccharide-induced BV-2 cells, while compounds , , and exhibited neuroprotective effects on HO-induced damage in PC12 cells. Compounds and could dose-dependently alleviate the dyskinesia in the UM0001 strain of , a double transgenic line of Aβ and pro-aggregation tau, suggesting an anti-Alzheimer's activity, reported for resin glycosides for the first time.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jnatprod.4c01182 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Three new chalcone C-glycosides from Carthami Flos].
Zhongguo Zhong Yao Za Zhi
July 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China Modern Research Center for Traditional Chinese Medicine, Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, China.
The chemical components of Carthami Flos were investigated by using macroporous resin, silica gel column chromatography, reversed-phase octadecylsilane(ODS) column chromatography, Sephadex LH-20, and semi-preparative high-performance liquid chromatography(HPLC). The planar structures of the compounds were established based on their physicochemical properties and ultraviolet-visible(UV-Vis), infrared(IR), high-resolution electrospray ionization mass spectrometry(HR-ESI-MS), and nuclear magnetic resonance(NMR) spectroscopic technology. The absolute configurations were determined by comparing the calculated and experimental electronic circular dichroism(ECD).
View Article and Find Full Text PDFUltrasound-Assisted Coupled with Resin-Based Purification for Sustainable Extraction of Steviosides from Leaves.
Molecules
August 2025
College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Stevioside, a natural high-intensity sweetener, is widely employed across the food, pharmaceutical, and daily chemical industries due to its intense sweetness and health benefits. However, traditional extraction and purification processes for steviol glycosides from are plagued by low efficiency, high energy consumption, substantial environmental impact, and inconsistent product quality. This study systematically optimized the extraction, decolorization, decontamination, and desalting processes to overcome these challenges.
View Article and Find Full Text PDFPurification of steroidal saponins from dioscoreae hypoglaucae rhizoma by macroporous resin and evaluation of their anti-inflammatory effect.
J Chromatogr B Analyt Technol Biomed Life Sci
November 2025
Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, China; International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei Pr
Dioscoreae hypoglaucae rhizome (DHR) is the dried rhizome of Dioscorea hypoglauca polibin, which is rich in steroidal saponins. The steroidal saponins present in DHR exhibit great pharmacological activities, particularly in inflammatory and anti-hyperuricemia effects. Despite steroidal saponins are recognized as primary bioactive components in DHR, the enrichment and purification processes of steroidal saponins is rare.
View Article and Find Full Text PDFBiological Activities of Glucosinolate and Its Enzymatic Product in (Lam.).
Int J Mol Sci
July 2025
Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China.
In this study, using 70% anhydrous ethanol as the extraction solvent, Lam. seed powder was extracted with the microwave-assisted extraction method, followed by purification using macroporous adsorbent resin NKA-9. The purified glucosinolate was subsequently hydrolyzed with myrosinase.
View Article and Find Full Text PDFEleven new resin glycosides, ipoalbins XI-XXI, from Ipomoea alba seeds.
Fitoterapia
August 2025
Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Ipomoea alba L. (Convolvulaceae), an annual vine native to tropical America, is primarily cultivated for ornamental purposes. The seeds are traditionally used as laxatives in herbal medicine, and young shoots are consumed as a food source.
View Article and Find Full Text PDF