Impact of slanted lateral rectus recession on pediatric patients with convergence insufficiency intermittent exotropia.

Background: Convergence insufficiency intermittent exotropia (CIX(T)) is a common type of strabismus in children, characterized by greater ocular deviation at near fixation compared to distance fixation. This study aimed to explore impact of slanted lateral rectus recession (S-LRc) compared to conventional lateral rectus recession (LR) on pediatric patients with CIX(T).

Methods: This retrospective study enrolled pediatric patients with CIX(T) at Shanxi Aier Eye Hospital between June 2022 and December 2024.

The Immunodeficiency Profile of Lymphocytes in the Patient with Moesin Gene Mutation During Different Infection.

Purpose: The Ezrin-Radixin-Moesin (ERM) family member moesin (MSN) plays a crucial role in reversibly linking F-actin to the cell membrane. Patients carrying MSN gene mutations consistently exhibit immunodeficiencies. However, due to the scarce number of reported cases worldwide, the mechanism by which MSN mutation leads to immune function defects remains unclear.

IgG4 elevation dilemma at the crossroads of helminth infection and IgG4-related disease: insights from a case report of pediatric paragonimiasis with persistent pericardial effusion.

Background: Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a systemic fibroinflammatory disorder defined by elevated serum IgG4, tissue IgG4+ plasma cell infiltration, and multi-organ involvement. Paradoxically, helminth infections may also trigger IgG4 elevation through Th2-polarized immune responses, creating diagnostic ambiguity when overlapping features occur. Critically, no studies have addressed whether IgG4-RD with helminthiasis can coexist in children or how to differentiate them when histopathology is unavailable.

Study of active ingredients and potential mechanisms of Yin-Chen-Si-Ni decoction in treating cholestatic jaundice based on UHPLC-Q-Exactive Orbitrap MS, network pharmacology, and molecular docking.

Yin-Chen-Si-Ni decoction (YCSND), as a common therapeutic practice recommendation in traditional Chinese medicine (TCM), has been applied to the management of cholestatic jaundice (CJ) syndromes. However, the effective components of YCSND and how this works have not been thoroughly documented. To elucidate the chemical map of YCSND in this work, the UHPLC-Q-Exactive Orbitrap MS analysis was carried out.

Multi-Cation Doped MnO Induced Dual Nonradical Peroxymonosulfate Activation Pathways for Efficient Degradation of Organics.

Regulating electron transfer between peroxymonosulfate (PMS) and catalysts is a promising strategy to enhance the activity of the catalytic system. This work demonstrates a multi-cation co-doping strategy (Fe,Ni,Cu) to engineer the electronic configuration of δ-MnO, creating a novel nanocatalyst that synergistically couples electron transfer (PMS-ETP) with singlet oxygen (O) generation for efficient pollutant degradation. The optimized catalyst exhibits excellent PMS activation efficiency, achieving a removal rate of >90.

The Molecular Breeding of Different Ecotype Varieties Resistant to Rice Blast with High Genome Collinearity.

The Yangtze River Delta (YRD) is one of the most important rice planting areas in China. Balancing the resistance, yield, and quality has always been a core issue in rice breeding due to the negative correlation among these three factors, while the broad-spectrum blast resistance gene is closely linked with , the major gene regulating days to heading (DTH), and a precise combination of their beneficial alleles plays a key role in synchronously improving blast resistance and the regional adaptability of rice in YRD. In this study, using the backcross progeny population derived from backbone parent ZD9471 and W1063, two alleles of were identified.

Discovery of TBK1Molecular Glue Degraders as a Potential Strategy for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD).

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cyst formation and renal failure. Tank-binding kinase 1 (TBK1), a key regulator of inflammation, represents a promising target for ADPKD treatment. In this study, we designed and synthesized a series of TBK1 degraders, including both PROTACs and molecular glues.

Auxiliary classifier adversarial networks with maximum subdomain discrepancy for EEG-based emotion recognition.

Domain adaptation (DA) is considered to be effective solutions for unsupervised emotion recognition cross-session and cross-subject tasks based on electroencephalogram (EEG). However, the cross-domain shifts caused by individual differences and sessions differences seriously limit the generalization ability of existing models. Moreover, existing models often overlook the discrepancies among task-specific subdomains.

Amplification of cGAS-STING pathway with "single-molecule multitarget" nanoparticles for chemo-immunotherapy of ovarian cancer.

With a low autoimmune risk and dedicated induction of type Ⅰ interferon production in immunotherapy, "STING therapy" holds broad prospects in the treatment of aggressive and metastatic cancers such as ovarian cancer (OC). Inducing pyroptosis constitutes a promising approach for activating the anti-tumor immune response. Nevertheless, compared to combination therapies, "single-molecule multitarget" drugs possess the merits of a lower interaction risk, more predictable pharmacokinetics and a lower cost of clinical trials.

Clinical practice guidelines for acute infectious diarrhea in children in China (2024).

Background: Some new progress and evidence have been made in the diagnosis and treatment of pediatric acute infectious diarrhea since the publication of the "Chinese clinical practice guidelines for acute infectious diarrhea in children" (2018 edition guidelines). The updated "Chinese clinical practice guidelines for acute infectious diarrhea in children" incorporates new evidence-based recommendations for managing acute infectious diarrhea in the Chinese pediatric population.

Data Sources: Building on the 2018 edition guidelines, expert panels reviewed clinical evidence, assessed preliminary recommendations, and conducted open-ended discussions to finalize the updated guidelines.

Development and validation of a predictive model for the risk of endocervical curettage positivity.

Objective: This study aimed to analyze the clinical characteristics of patients undergoing endocervical curettage (ECC), identify factors influencing ECC positivity, and develop a predictive model to assess the risk of positive ECC results. The goal was to assist clinicians in making ECC decisions and reduce missed diagnoses of cervical lesions.

Methods: A retrospective analysis was performed on 953 patients who underwent colposcopically directed biopsy and ECC at the gynecology clinic of the First Affiliated Hospital of Xi'an Jiaotong University between October 2021 and September 2023 due to abnormal screening results.

The effects of blood flow restriction training on early muscle strength and mid-term knee function following anterior cruciate ligament reconstruction: a systematic review and meta-analysis.

Objective: Early restoration of muscle strength and knee joint function after anterior cruciate ligament reconstruction (ACLR) is a critical goal in the rehabilitation process. Blood flow restriction training (BFRT), a low-load training method, has gained attention in musculoskeletal rehabilitation in recent years, but its specific effects in ACLR rehabilitation remain unclear.

Methods: Relevant literature up to December 20, 2024, was searched in the PubMed, Embase, Cochrane, and Web of Science databases, and study selection was performed according to PRISMA guidelines.

Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-]pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer.

The p21-activated kinase 4 (PAK4), a key regulator of malignancy, is negatively correlated with immune infiltration and has become an emergent drug target of cancer therapy. Given the lack of high efficacy PAK4 inhibitors, we herein reported the identification of a novel inhibitor bearing a tetrahydrobenzofuro[2,3-]pyridine tricyclic core and possessing high potency against MIA PaCa-2 and Pan02 cell lines with IC values of 0.38 and 0.

STING pathway activation with cisplatin polyprodrug nanoparticles for chemo-immunotherapy in ovarian cancer.

Cisplatin serves as the cornerstone medication in ovarian cancer (OC) chemotherapy; however, numerous resistance factors exist, resulting in unsatisfactory clinical treatment outcomes. Concurrently, OC frequently establishes an immunosuppressive microenvironment, which further exacerbates the challenges of cisplatin chemotherapy. Hence, it is particularly significant to explore a therapeutic approach capable of overcoming cisplatin resistance while reversing the immunosuppressive microenvironment of OC.

Safety and effectiveness of inhaled sedation in critically ill patients: a systematic review and meta-analysis.

Background: Sedation is a landmark treatment in the intensive care unit; however, the disadvantages of intravenous sedative drugs are increasingly prominent. Volatile sedation is becoming increasingly popular in ICUs due to fewer technical issues with the development of anaesthesia reflectors.

Objective: To explore the safety and effectiveness of inhaled sedation in critically ill patients.

Plasma tsRNA Signatures Serve as a Novel Biomarker for Bladder Cancer.

Bladder cancer (BLCA) is one of the most common tumors of the urinary tract. The diagnosis of BLCA is mostly by invasive tests, which are damaging and unsuitable for early screening. Current non-invasive diagnostic modalities are insufficient in sensitivity and specificity.

Adult split liver transplantation to treat liver cancer: a single-center retrospective study.

Background: The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation (SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy of SLT are still controversial.

An Intelligent Maneuver Decision-Making Approach for Air Combat Based on Deep Reinforcement Learning and Transformer Networks.

The traditional maneuver decision-making approaches are highly dependent on accurate and complete situation information, and their decision-making quality becomes poor when opponent information is occasionally missing in complex electromagnetic environments. In order to solve this problem, an autonomous maneuver decision-making approach is developed based on deep reinforcement learning (DRL) architecture. Meanwhile, a Transformer network is integrated into the actor and critic networks, which can find the potential dependency relationships among the time series trajectory data.

A Self-Assembled Nano-Molecular Glue (Nano-mGlu) Enables GSH/HO-Triggered Targeted Protein Degradation in Cancer Therapy.

Molecular glues are promising protein-degrading agents that hold great therapeutic potential but face significant challenges in rational design, effective synthesis, and precise targeting of tumor sites. In this study, we first overcame some of these limitations by introducing a fumarate-based molecular glue handle onto specific ligands of therapeutic kinases (TBK1, FGFR, and Bcr-Abl), resulting in the effective degradation of these important cancer targets. Despite the broad applicability of the strategy, we unexpectedly discovered potent and widespread cytotoxicity across various cell lines, including noncancerous ones, rendering it less effective in cancer therapy.

Rapid Degradation of Bisphenol F Using Magnetically Separable Bimetallic Biochar Composite Activated by Peroxymonosulfate.

Peroxymonosulfate (PMS)-based advanced oxidation processes have shown potential for the removal of organic contaminants; however, the preparation of catalysts with high degradation efficiencies and rapid reaction rates remains a challenge. In this study, we have successfully synthesized CoFe bimetallic modified corn cob-derived biochar (CoFe/BC) for the activation of PMS, achieving the rapid and efficient degradation of bisphenol F (BPF). The synthesized CoFe/BC catalyst demonstrated excellent catalytic performance, achieving over 99% removal within 3 min and exhibiting a removal rate of 90.

Nocardia farcinica pneumonia complicated by pneumocystis jiroveci infection in children with Neuromyelitis Optica Spectrum Disorders: a case report and literature review.

Background: Nocardiosis is an opportunistic infection that has a low prevalence rate, its clinical manifestations are atypical and can be easily misdiagnosed as other diseases. The correct diagnosis and treatment are frequently delayed by various factors. In this case report, we present a pediatric patient with Neuromyelitis Optica Spectrum Disorders who developed Nocardia farcinica pneumonia complicated by pneumocystis jiroveci infection.

Multi-layer transfer learning algorithm based on improved common spatial pattern for brain-computer interfaces.

In the application of brain-computer interface, the differences in imaging methods and brain structure between subjects hinder the effectiveness of decoding algorithms when applied on different subjects. Transfer learning has been designed to solve this problem. There have been many applications of transfer learning in motor imagery (MI), however the effectiveness is still limited due to the inconsistent domain alignment, lack of prominent data features and allocation of weights in trails.