FTOregulated mA modification of primiR139 represses papillary thyroid carcinoma metastasis.

Objectives: Increasing detection of low-risk papillary thyroid carcinoma (PTC) is associated with overdiagnosis and overtreatment. N6-methyladenosine (mA)-mediated microRNA (miRNA) dysregulation plays a critical role in tumor metastasis and progression. However, the functional role of mA-miRNAs in PTC remains unclear.

Synergistically Enhanced NiCo(OH)@NiS Heterojunction Catalyst for High-Performance Ethanol Electrooxidation.

Coupling the ethanol electrooxidation reaction (EOR) with the hydrogen evolution reaction is an effective way to obtain green energy. Although Ni-based catalysts have the characteristics of low cost and good stability, meanwhile, the activity needs to be further improved. Here, we report a Ni-based heterojunction EOR catalyst, NiCo(OH)@NiS, composed by two phases of NiS and NiCo(OH).

CD2-CD58 axis orchestrates cytotoxic T lymphocyte function and metabolic crosstalk in breast cancer brain metastasis.

This study investigates the impact of the CD2-CD58 signaling axis on effector T cell function and tumor metabolic crosstalk in breast cancer brain metastasis (BCBM) using single-cell transcriptomic analysis. scRNA-seq data analysis revealed the critical role of CD2-CD58 signaling between CD8 T cells and tumor cells in BCBM. Functional assays demonstrated that CD2 knockdown inhibited cytotoxic T lymphocyte (CTL) proliferation, activation, and cytotoxicity, leading to impaired tumor cell recognition and enhanced proliferation, migration, and invasion.

Machine learning-based quantification of overall and internal ultrasound characteristics for diagnosing malignant partially cystic thyroid nodules.

Introduction: Partially cystic thyroid nodules (PCTNs) with malignant potential are frequently underestimated due to limited recognition of their sonographic characteristics.

Methods: This retrospective analysis included 486 PCTNs identified between March 2021 and September 2022. Machine learning (ML) was employed to quantitatively evaluate the overall ultrasound characteristics of the whole nodule as well as the internal ultrasound characteristics of its solid part.

Biovision-Inspired Perovskite Intelligent Camera for Panchromatic and Metameric Sensing.

Biological vision systems excel at acquiring and processing information, but there is often a trade-off between these capabilities. For instance, mantis shrimp possess exceptional spectral sensing but poor color perception due to limited neural processing. Taking the best of both worlds, the mantis shrimp's spectral detection ability and the human-like visual processing power are integrated to achieve full-color perception.

The relationship between elderly nutritional risk index and short-term all-cause mortality in critically ill patients with cerebral injury: a retrospective cohort study from two cohorts.

Background: The Geriatric Nutritional Risk Index (GNRI) is a simple and objective tool for assessing the risk of malnutrition, with potential practicality in critically ill patients with cerebral injury (CIPCI). However, the current evidence is still limited.

Method: Patients diagnosed with cerebral injury were retrospectively retrieved from the Medical Information Marketplace for Intensive Care (MIMIC-IV) and the Affiliated Jinyang Hospital of Guizhou Medical University.

Non-Destructive Detection of Pomegranate Blackheart Disease via Near-Infrared Spectroscopy and Soft X-ray Imaging Systems.

Pomegranate blackheart disease, as an internal disease affecting the global pomegranate industry, is difficult to identify externally and urgently requires non-destructive detection methods for rapid diagnosis. This study established discriminative models for blackheart disease severity in pomegranates by using near-infrared (NIR) spectroscopy and soft X-ray imaging techniques. The results showed that the optimal NIR-based discriminative model, constructed with a Random Forest (RF) algorithm based on spectra preprocessed by the second-derivative (D2) denoising and a Competitive Adaptive Reweighted Sampling (CARS) algorithm, achieved a prediction set accuracy of 86.

Inhibition of Endothelial HIF-1α by IDF-11774 Attenuates Retinal Neovascularization and Vascular Leakage.

Purpose: In ischemic retinopathy (IR), hypoxia-inducible factor (HIF)-1α contributes to vision-threatening pathological retinal neovascularization (RNV). This study investigated the therapeutic efficacy and action mechanisms of the newly developed HIF-1α inhibitor IDF-11774 for IR in hypoxia-exposed human umbilical vein endothelial cells (HUVECs) and human retinal microvascular endothelial cells (HRMECs), as well as an oxygen-induced retinopathy (OIR) model mice.

Methods: The effect of IDF-11774 on HIF-1α expression in HUVECs was assessed by quantitative real-time polymerase chain reaction (RT-qPCR), immunoblotting, and immunostaining, and effects on angiogenic potential were evaluated by cell proliferation, scratch wound, Transwell, and tube formation assays.

A Highly Sensitive Formaldehyde Gas Sensor Based on AgO and PtO Co-Decorated LaFeO Nanofibers Prepared by Electrospinning.

The widespread use of formaldehyde in both industrial and household products has raised significant health concerns, emphasizing the need for highly sensitive sensors to monitor formaldehyde concentrations in the environment in real time. In this study, we report the fabrication of a highly sensitive formaldehyde gas sensor based on AgO and PtO co-decorated LaFeO nanofibers, prepared by electrospinning, with an ultra-low detection limit of 10 ppb. Operating at an optimal temperature of 210 °C, the sensor exhibits high sensitivity, with a response value of 283 to 100 ppm formaldehyde-nearly double the response of the Ag-only decorated LaFeO sensor.

An investigation of the relationship between sPD-1, sPD-L1 and severe pneumonia patients admitted to ICU and its clinical significance.

Background: Soluble programmed cell death 1 (sPD-1) and its ligand (sPD-L1) have emerged as potential biomarkers for early identification and risk stratification in patients with severe pneumonia (SP). However, there is a lack of robust laboratory evidence supporting their clinical utility. This study aimed to explore the relationship between sPD-1/sPD-L1 levels and clinical outcomes in SP patients.

[Exploration of the pathogenic mechanism of a novel c.661_664dup (p.P222Lfs*60) variant of SOX10 gene].

Objective: To explore the pathogenic mechanism of a child with Waardenburg syndrome type 4C due to a c.661_664dup (p.P222Lfs*60) variant of SOX10 gene through in vitro experiments.

Identification of mitophagy-related biomarkers with immune cell infiltration in psoriasis.

Background: Psoriasis is an inflammatory disorder characterized by scaly erythematous plaques and significant comorbidities. Recent studies have suggested that impaired mitophagy, the cellular mechanism for removing dysfunctional mitochondria, may contribute to the pathogenesis of psoriasis.

Methods: In this study, we analyzed bulk RNA sequencing data from 167 healthy individuals and 177 patients with psoriasis obtained from the Gene Expression Omnibus database (GSE30999 and GSE54456).

Revealing umbrella bending as a reporter mode in the D+CH reaction.

How the non-reacting moiety of a molecule influences a polyatomic reaction has been a topic of much research interest. Here we present a comprehensive investigation of the D + CH → HD + CH reaction, a benchmark polyatomic elementary reaction with CH as the non-reacting moiety, employing a high-resolution crossed molecular beams apparatus and an accurate seven-dimensional wave packet method. An interesting angular distribution of the CH(v' = 1) product umbrella bending vibrational state is observed to scatter more in the sideways direction than the CH(v' = 0) one.

Challenges and Opportunities for Improving Management of Patients with nAMD and DME in China: Insights from a Global Survey on Anti-VEGF Therapy.

Introduction: This survey investigated the challenges and opportunities during anti-vascular endothelial growth factor (VEGF) therapy in Chinese patients.

Methods: The survey was conducted in six hospitals from different regions in China, as part of the Barometer global survey. Paper-based optical mark recognition (OMR) questionnaires were answered by 498 and 527 patients who had been diagnosed with neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME), respectively, and were currently receiving or had previously received anti-VEGF injections, and by physicians who prescribe and/or administer anti-VEGF injections for the treatment of nAMD/DME.

Macroscopic Homochiral Twist Enables Continuous In Situ Rotational Movement in Photomechanical Assemblies.

Various light-driven motions have been reported with molecular assemblies, yet continuous in situ rotational movement is rare, which is essential to simulate biological rotary motors and achieve efficient energy transduction. Inspired by natural helical systems, here, we introduce the chirality into the assembly and construct a macroscopic homochiral twisted assembly at the microscale. This assembly (BNP twist) rotated continuously under UV light (365 nm) irradiation.

How is the human microbiome linked to kidney stones?

In recent years, the incidence of kidney stones has continued to rise worldwide, and conventional treatments have limited efficacy in treating stones associated with recurrent or metabolic abnormalities. The microbiome, as the 'second genome' of the host, is involved in the development of kidney stones through metabolic regulation, immune homeostasis and inflammatory response. Studies have shown that the urinary microbiome of healthy people is dominated by commensal bacteria such as Lactobacillus and Streptococcus, which maintain microenvironmental homeostasis, whereas patients with renal stones have a significantly reduced diversity of intestinal and urinary microbiomes, with a reduced abundance of oxalic acid-degrading bacteria (e.

CircSRPK1 mediated by the exon junction complex promotes gastric cancer progression by interacting with hnRNP A2B1 to regulate RON mRNA alternative splicing.

Gastric cancer (GC) is one of the most common malignant tumors with high heterogeneity, and its etiology and pathogenesis are unclear. Recently, many aberrantly alternatively spliced isoforms of the receptor tyrosine kinase recepteur d'origine nantais (RON) have been shown to play vital roles in GC development. Serine/arginine protein kinase 1 (SRPK1) is widely recognized as a key splicing factor kinase that regulates various steps of alternative splicing.

Exercise interventions in patients with multiple myeloma: a scoping review.

Background: Patients with multiple myeloma (MM) frequently experience impaired motor function and reduced quality of life. While exercise interventions play a vital role, no standardized guidelines tailored specifically to MM patients currently exist. This article reviews the scope of exercise interventions for patients with MM and further analyzes the current situation, providing references for early rehabilitation.

Clinically Diagnose Asthma and Monitor Its Severity Using an Ultrasensitive Chemiresistive Nitric Oxide (NO) Gas Sensor via Exhaled Breath Analysis Assisted by Pattern Recognition.

Fractional exhaled nitric oxide (FeNO) is widely recognized as a reliable biomarker for asthma. FeNO sensors can help diagnose asthma and monitor its severity. In this study, an ultrasensitive chemiresistive gas sensor, sensitive to the key breath biomarkers of asthma─nitric oxide (NO) and HS─was fabricated using Ag-decorated ZnO.

Characterization of Key Intermediates and Products from the Ozonolysis of Styrene-Like Compounds.

Stabilized Criegee intermediates (sCIs) are key reactive species in atmospheric chemistry. Styrene-like compounds are special aromatics, as they can react with the ozone to generate phenyl-substituted sCIs (CHCHOO), yet no prior study has directly characterized such sCIs. This study took styrene and trans-β-methylstyrene as proxies for styrene-like compounds.

Sustained - release microspheric gel of meloxicam: Preparation, evaluation in vitro and in vivo.

Unlabelled: Osteoarthritis (OA) is the common form of chronic joint disease. The disease progression can affect all joints of the body, seriously affecting patients’ quality of life. The most effective clinical treatment for OA at the moment is the oral or intravenous administration of non-steroidal anti-inflammatory drugs, such as meloxicam (MX).

Myeloid PGGT1B Deficiency Promotes Psoriasiform Dermatitis by Promoting the Secretion of Inflammatory Factors.

Psoriasis pathogenesis involves dysregulated immune responses, yet the role of protein prenylation (particularly PGGT1B-mediated geranylgeranylation) in macrophage-driven inflammation remains poorly understood. This study aims to explore the role and molecular mechanism of protein geranylgeranyltransferase type I subunit beta (PGGT1B) in the development of psoriasis. Myeloid cell-specific PGGT1B gene knockout mice were generated, and a mouse psoriasis model was established with imiquimod to study the role and mechanism of PGGT1B gene downregulation-induced macrophage activation in the pathogenesis of psoriasis.

Tandem Visual Recognition of Cu and Chiral Tartaric Acid by Sequence Gel Formation and Collapse.

A chiral gelator ()-HL with multiple carboxyl groups based on a 1,1'-bi-2,2'-naphthol (BINOL) skeleton was prepared, and it could form a supramolecular gel under the induction of water in DMSO/HO and DMF/HO (1/1, /). In the EtOH/HO system, the original partial gel transformed into a stable metal-organic gel (MOG), specifically with Cu among 20 metal ions. It is proposed that Cu coordinates with the carboxyl groups of ()-HL to form a three-dimensional network structure.

Evaluation of one-stop diagnosis and management at the collaborative national standardized metabolic disease management center.

Objective: To evaluate the effectiveness of diagnosis and treatment at the collaborative National Standardized Metabolic Disease Management Center.

Methods: A nationally standardized selection process was used to recruit the healthcare team, followed by standardized training and assessment. The management center was equipped with coordinated healthcare resources, and clear workflows and responsibilities were established.

HNF4A Regulated APEH Deficiency Promotes UPR Activation in Diabetic Kidney Disease.

Diabetic kidney disease (DKD) constitutes a severe microvascular complication of diabetes and ranks among the leading causes of end-stage renal disease (ESRD). Endoplasmic reticulum stress (ERS) significantly contributes to the initiation and progression of DKD, as persistent ERS leads to excessive activation of the unfolded protein response (UPR), triggering cellular apoptosis. Protein carbonylation, a prominent oxidative modification caused by reactive oxygen species (ROS), is recognized as a critical initiator of ERS.