[Research progress on the mechanism of activating transcription factor 5 in regulating cellular inflammatory stress response].

Activating transcription factor 5 (ATF5) is a member of the activating transcription factor/cyclic adenosine monophosphate response element binding protein (ATF/CREB) family. As a stress-induced transcription factor, ATF5 plays a crucial role in cellular inflammatory stress responses. Under cellular inflammatory stress conditions, ATF5 maintains cell homeostasis and survival by regulating key genes in the mitochondrial unfolded protein response (UPR) and endoplasmic reticulum stress (ERS).

Triglyceride-Glucose Index Is Associated With Restenosis After Percutaneous Coronary Intervention With Drug-Coated Balloons in Patients With Coronary Artery Disease.

Background: Drug-coated balloon (DCB) has become a common treatment, but restenosis may still occur after DCB. The association of the triglyceride-glucose (TyG) index with coronary atherosclerotic heart disease prognosis has been demonstrated. However, the relationship between the TyG index and restenosis after DCB-only remains unknown.

The Modulation of Neuroimmune Responses in Peripheral Inflammation.

The brain, as the "commander-in-chief" of the human body, is known to pick up the peripheral situation and dictate orders to the periphery on time, and the immune system makes no exception. Inflammation is a defensive reaction of the body, which can be beneficial, however, unrestricted inflammation can result in life-threatening injuries and multi-organ dysfunction. The intricate interaction between the nervous and the immune system would prevent inflammation from spreading indefinitely.

An investigation of the relationship between sPD-1, sPD-L1 and severe pneumonia patients admitted to ICU and its clinical significance.

Background: Soluble programmed cell death 1 (sPD-1) and its ligand (sPD-L1) have emerged as potential biomarkers for early identification and risk stratification in patients with severe pneumonia (SP). However, there is a lack of robust laboratory evidence supporting their clinical utility. This study aimed to explore the relationship between sPD-1/sPD-L1 levels and clinical outcomes in SP patients.

Severe rhabdomyolysis induced by bezafibrate in the treatment of severe acute pancreatitis with hyperlipidemia: A case report.

Rationale: The important etiological treatment for hyperlipidemic severe acute pancreatitis is to reduce blood lipid. Statins or fibrates are often selected in clinical practice. Most reports indicate that statins or statin combination therapy can cause serious complications such as rhabdomyolysis syndrome (RM) and even poor prognosis.

[Glutamatergic neurons in paraventricular nucleus of the thalamus promote wakefulness during propofol anesthesia].

Objective: To determine whether the glutamatergic neurons in the paraventricular nucleus of the thalamus (PVT) is involved in the change of consciousness induced by propofol through a combination of behavioral and electroencephalography (EEG) recordings.

Methods: Healthy male VGluT2-IRES-Cre mice aged 8-12 weeks were used in this experiment. (1) The glutamatergic neurons in the PVT was selectively damaged, and its effect on propofol anesthesia induction and recovery times as well as the energy of EEG in different frequency bands were observed.

Triiodothyronine activates THRβ to promote PGC1α expression alleviating PQ-induced pulmonary fibrosis.

Thyroid hormone (TH) and it most active form triiodothyronine (T3) are crucial in promoting mitochondrial biogenesis and maintaining cellular homeostasis during the stress response, but their role in paraquat (PQ)-induced pulmonary fibrosis isunclear. The aim of this study was to examine whether there was a deficiency of TH in mouse lung tissue after PQ administration, and to explore the effect of T3, and potential mechanisms of action, in alleviation of PQ-induced pulmonary fibrosis. We found that the activity and expression of iodothyronine deiodinase 2 (DIO2), an enzyme that activates TH, were higher in the lungs of patients with pulmonary fibrosis than in controls.

Risk Factors for Death in Patients with Severe Acute Pancreatitis in Guizhou Province, China.

Aim: To compare the clinical characteristics of survival and nonsurvival patients with severe acute pancreatitis (SAP) and explore the risk of mortality in SAP patients.

Methods: This was a single-center retrospective study performed in a severe acute pancreatitis diagnosis and treatment center. According to the outcome, SAP patients were divided into survival group and nonsurvival group.

UCP2 overexpression activates SIRT3 to regulate oxidative stress and mitochondrial dynamics induced by myocardial injury.

Objective: Our previous study found that overexpression of uncoupling protein-2 (UCP2) had a protective effect on lipopolysaccharide (LPS)-induced sepsis cardiomyocytes. The aim of this study was to explore the effect and mechanism of uncoupling protein-2 (UCP2) on myocardial ischemia-reperfusion injury.

Methods: In this study, we established hypoxia-reoxygenation (HR) injury model in rats and isolated cardiomyocytes of newborn rats.

Non-small cell lung cancer with bone metastasis and pneumocystis pneumonia in a pregnant woman: a case report and literature review.

Background: Cancer case during pregnancy is rare, but it is the second leading cause of maternal mortality.

Case Presentation: A-32-year old pregnant woman with a gestational age of 37 weeks was admitted to the hospital due to repeated coughing for 5 months. She received Veno-Venous Extracorporeal Membrane Oxygenation (V-V ECMO) treatment for severe hypoxemia after delivery.

Fatal invasive pulmonary aspergillosis in non-immunocompromised host: A case report.

Rationale: Invasive pulmonary aspergillosis (IPA) is an uncommon but life-threatening disease. The disease often occurs in immunocompromised patients or critically ill patients. Here, we reported that IPA occurred in a non-immunocompromised host.

[Hyperoxia caused intestinal metabolism disorder in mice].

Objective: To investigate the effect of hyperoxia on intestinal metabolomics in mice.

Methods: Sixteen 8-week-old male C57BL/6 mice were randomly divided into hyperoxia group and control group, with 8 mice in each group. The hyperoxia group was exposed to 80% oxygen for 14 days.

An Outbreak of Paederus Dermatitis in a Suburban Hospital in Southwest China: A Report of 134 Cases and Review of Literature.

Reports of paedoptera dermatitis are commonly found in tropical and subtropical regions, while reports in China are rare. In September 2022, an outbreak of paedoptera dermatitis occurred in a minority autonomous county in southwestern China. Here, we report 134 patients with paedoptera dermatitis who were treated at the People's Hospital of Sandu Shui Autonomous County.

The Changes of Antioxidant Contents and Antioxidant Activities of the Tomato Cultivar Fentailang during the Maturity Stages.

The aim of this study was to analyze the contents of ascorbic acid, phenolics, flavonoids, carotenoids, lycopene, β-carotene and their antioxidant activities in the different maturity stages of tomatoes. The results showed that tomatoes in pink and red stages exhibited higher contents of ascorbic acid concomitant with the correspondent higher hydrophilic antioxidant activities. The contents of phenolics, carotenoids and lycopene were increasing till the red maturity stage.

Long Noncoding RNA MIR600HG Binds to MicroRNA-125a-5p to Prevent Pancreatic Cancer Progression Via Mitochondrial Tumor Suppressor 1-Dependent Suppression of Extracellular Regulated Protein Kinases Signaling Pathway.

Objectives: Significance of long noncoding RNAs in pancreatic cancer (PC) progression has been documented. Here, we identified a novel long noncoding RNA MIR600HG in PC and its underlying mechanism during PC progression.

Methods: Through bioinformatics analysis, we selected MIR600HG, microRNA-125a-5p (miR-125a-5p), and mitochondrial tumor suppressor 1 (MTUS1) as objects with their expression patterns assayed in the collected PC tissues and PC cells.

The Clinical Characteristics and Outcome of Elderly Patients With Acute Pancreatitis.

Objectives: This study aimed to identify the risk factors for the progression of acute pancreatitis (AP) to severe acute pancreatitis (SAP) and death in elderly patients.

Methods: This was a single-center retrospective study conducted in a tertiary teaching hospital. Data on patient demographics, comorbidities, duration of hospitalization, complications, interventions, and mortality rates were collected.

Graves' hyperthyroidism induced pancytopenia, epilepsia and muscle weakness: A case report.

Rationale: Pancytopenia and epilepsia are rare complications of Graves' disease (GD). Muscle weakness is a physical sign of GD. It is extremely rare for GD patients to present 3 symptoms at the same time.