Bayesian integration of longitudinal and survival outcomes in Alzheimer's disease prediction.

Introduction: Accurate prediction of Alzheimer's disease (AD) dementia onset and progression to mild cognitive impairment (MCI) is crucial for early intervention and clinical trial design. This study presents a predictive framework leveraging Bayesian model averaging (BMA) with a multivariate functional mixed model (MFMM) to integrate multivariate longitudinal outcomes and survival data.

Methods: The training cohort included 1012 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI).

The prevalence of FV Hong Kong in patients with thrombotic disorders in South China.

To investigate the prevalence of FV Hong Kong(p.Arg306Gly) variant in patients with thrombotic disorders in South China, and to explore the association between FV Hong Kong and thrombosis according to genotype and clinical manifestations of the patients. A total of 367 patients with thrombotic disorders and 555 healthy volunteers in South China were screened by exon sequencing to identify FV Hong Kong variant carriers.

A novel longitudinal rank-sum test for multiple primary endpoints in clinical trials: Applications to neurodegenerative disorders.

Neurodegenerative disorders such as Alzheimer's disease (AD) present a significant global health challenge, characterized by cognitive decline, functional impairment, and other debilitating effects. Current AD clinical trials often assess multiple longitudinal primary endpoints to comprehensively evaluate treatment efficacy. Traditional methods, however, may fail to capture global treatment effects, require larger sample sizes due to multiplicity adjustments, and may not fully utilize the available longitudinal data.

Quercetin promotes angiogenesis and protects the blood-spinal cord barrier structure after spinal cord injury by targeting the PI3K/Akt signaling pathway.

Background: Revascularization and reconstruction of the blood-spinal cord barrier (BSCB) following spinal cord injury (SCI) play crucial roles in supplying essential nutrients and fostering a supportive microenvironment for neural network reconstruction. Thus, facilitating vascular regeneration and maintaining BSCB integrity are key therapeutic targets for functional recovery post-SCI.

Methods: Ischemia-induced pathological alterations in spinal cord microvascular endothelial cells were modeled in vitro using oxygen-glucose deprivation/reperfusion (OGD/R)-exposed bEnd.

Ensemble survival analysis for preclinical cognitive decline prediction in Alzheimer's disease using longitudinal biomarkers.

BackgroundPredicting the risk of clinical progression from cognitively normal (CN) status to mild cognitive impairment (MCI) or Alzheimer's disease (AD) is critical for early intervention in AD. Traditional survival models often fail to capture complex longitudinal biomarker patterns associated with disease progression.ObjectiveWe propose an ensemble survival analysis framework integrating multiple survival models to improve early prediction of clinical progression in initially cognitively normal individuals.

Ketogenic diet and quercetin promote the recovery of motor function in rats with spinal cord injury.

Spinal cord injury (SCI) is a devastating neurological disorder, and currently, there are no effective therapeutic options to promote the recovery of motor function. Therefore, exploring safe and effective post-SCI repair strategies is crucial. In our study, we investigated the therapeutic effects of ketogenic diet (KD) and quercetin, both separately and in combination, on the recovery of motor and neurological functions in rats with SCI.

Correction: Mitochondrial genome assembly and comparative analysis of decaploid .

[This corrects the article DOI: 10.3389/fpls.2025.

Validation of the Polish version of the Movement Disorder Society Non-motor Rating Scale (MDS-NMS).

Aim Of The Study: We aimed to translate and validate the Polish version of the MDS-NMS and compare it with the original English version.

Clinical Rationale For The Study: Non-motor symptoms (NMS) affect a significant portion of the Parkinson's disease (PD) patient population and may negatively impact their quality of life. Non-motor symptoms may contribute to an increased sense of illness among patients and to a greater burden upon their caregivers.

Designing Single-Arm Clinical Trials: Principles, Applications, and Methodological Considerations.

Single-arm trials (SATs) are clinical studies without a parallel control group, serving as a vital alternative to randomized controlled trials (RCTs) in scenarios where traditional trial designs are impractical. These trials are particularly relevant in rare diseases, advanced malignancies, novel treatment modalities, and life-threatening conditions, where ethical concerns, logistical challenges, or small patient populations limit the feasibility of RCTs. SATs enable expedited evaluation of therapeutic interventions, often forming the foundation for regulatory approvals.

De Novo Variant Associated With Juvenile-Onset Temporal Lobe Epilepsy With Favorable Outcomes.

Genetic factors are estimated to contribute to 80% of people with epilepsy. However, only four genes were reported to be associated with temporal lobe epilepsy (TLE). This study is aimed at investigating the association between and TLE.

Longitudinal Study of Treatment Variability for Parkinson's Disease across Specialized Centers.

Background: Real-world evidence on treatment practices in Parkinson's disease (PD) has been limited due to the difficulty in collecting comprehensive and generalizable clinical data.

Objectives: We sought to identify treatment patterns and test how treatment changed in response to (1) falling, (2) worsening disease, and (3) worsening quality of life across PD specialized centers.

Methods: We used the Parkinson Outcomes Project data collected from 2010 to 2023 across 31 international PD specialized centers.

Mitochondrial genome assembly and comparative analysis of decaploid .

Introduction: Decaploid is a new tea oil species discovered in recent years that is unique to Hainan. This species has high nutritional and medicinal value and shows strong adaptability in the growth process. Mitochondria play an important role in plant cells and have an independent genetic system.

Fe-deficiency-induced chlorosis 1 is essential for chloroplast iron transport and homeostasis under continuous light conditions in Arabidopsis.

Chloroplasts require iron for photosynthesis; however, the transport mechanisms remain poorly understood. This study identifies Arabidopsis Fe-deficiency-induced chlorosis 1 (FIC1), localized in the chloroplast inner membrane, as essential for iron redistribution from developed to newly developing leaves under continuous light (CL) conditions. CL induces FIC1 expression in newly developing leaves.

Variants in CSMD2 and CSMD3, genes involved in synaptogenesis, are associated with epilepsies.

Objective: The CSMD genes, including CSMD1, CSMD2, and CSMD3, encoding synaptic transmembrane proteins, play important roles in neuronal maturation, growth of dendrites, and processes of synapses. Our recent study showed that CSMD1 was associated with developmental epileptic encephalopathy (DEE) and generalized epilepsy. The significance of CSMD2 and CSMD3 in human disease is unknown.

DYNAMIC PREDICTION WITH MULTIVARIATE LONGITUDINAL OUTCOMES AND LONGITUDINAL MAGNETIC RESONANCE IMAGING DATA.

Alzheimer's Disease (AD) is a common neurodegenerative disorder impairing multiple domains. Recent AD studies, for example, the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, collect multimodal data to better understand AD severity and progression. To facilitate precision medicine for high-risk individuals, it is essential to develop an AD predictive model that leverages multimodal data and provides accurate personalized predictions of dementia occurrences.

The F-box protein RCN127 enhances rice tillering and grain yield by mediating the degradation of OsTB1 and OsTCP19.

Tillering ability is a crucial agronomic trait that determines rice yield potential. OsTB1 (the rice ortholog of TEOSINTE BRANCHED 1) and OsTCP19 of the TCP protein family are two key repressors of rice tillering. Until now, their post-translational regulatory mechanisms have remained elusive.

Relationships between nutritional intake, appetite regulation, and mental health with body composition among female college students with overweight and obesity.

Introduction: The prevalence of overweight and obesity among college girls is a significant public health concern. This cross-sectional study investigated the relationships between nutritional intake, appetite regulation, and mental health with body composition among overweight and obese college girls.

Methods: This study involved 72 college girls.

A non-parametric U-statistic testing approach for multi-arm clinical trials with multivariate longitudinal data.

Randomized clinical trials (RCTs) often involve multiple longitudinal primary outcomes to comprehensively assess treatment efficacy. The Longitudinal Rank-Sum Test (LRST) [17], a robust U-statistics-based, non-parametric, rank-based method, effectively controls Type I error and enhances statistical power by leveraging the temporal structure of the data without relying on distributional assumptions. However, the LRST is limited to two-arm comparisons.

Experimental study on instability and failure mechanism of sandstone under freeze-thaw and load.

Freeze-thaw damage is the primary cause of instability in rock slopes in cold regions, while the mechanical properties of rock are significantly influenced by loading rate. This study aims to investigate the evolution of mechanical behavior of sandstone under the coupled effects of loading rate and freeze-thaw cycles. Uniaxial compression tests were conducted on sandstone specimens subjected to different numbers of freeze-thaw cycles (0, 30, 50, 70) and loading rates (0.

The G-protein γ subunit DEP1 facilitates brassinosteroid signaling in rice via a MYB-bHLH-ARF module.

G-protein signaling and brassinosteroid (BR) phytohormones play important roles in regulating rice (Oryza sativa) yield-related plant architecture, such as leaf inclination and grain size. However, the relationship between G-proteins and BR signaling has not been fully elucidated in rice. The present study indicates that the G-protein Gγ subunit DENSE AND ERECT PANICLE 1 (DEP1) positively regulates BR signaling in rice and that BRs promote DEP1 nuclear entry through GRAIN NUMBER ASSOCIATED (GNA).

Integrative Multi-Omics and Multivariate Longitudinal Data Analysis for Dynamic Risk Estimation in Alzheimer's Disease.

Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder, characterized by diverse cognitive and functional impairments that manifest heterogeneously across individuals, domains, and time. The accurate assessment of AD's severity and progression requires integrating a variety of data modalities, including multivariate longitudinal neuropsychological tests and multi-omics datasets such as metabolomics and lipidomics. These data sources provide valuable insights into risk factors associated with dementia onset.

Identification of as a causative gene of generalised epilepsy.

Background: The microtubule actin crosslinking factor 1 ( gene encodes microtubule-microfilament cross-linking factor 1 that plays an essential role in the embryonic brain development. variants were associated with lissencephaly-9 (LIS9). However, the -epilepsy relationship was unknown.