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http://dx.doi.org/10.1002/mdc3.70162 | DOI Listing |
Cerebellum
September 2025
Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL, USA.
Oculopalatal tremor is a rare neurological disorder characterized by rhythmic oscillations of ocular and palatal muscles. This phenomenon is commonly associated with hypertrophic degeneration of the inferior olive due to loss of GABAergic cerebello-olivary fibers. Oculopalatal tremor highlights the complex interplay between cerebellar, mesodiencephalic, and olivary networks.
View Article and Find Full Text PDFJ Parkinsons Dis
September 2025
Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
BackgroundPeripheral neuropathy in Parkinson's disease (PD) may not be an isolated pathological phenomenon but may interact with other non-motor symptoms.ObjectiveTo conduct a comprehensive investigation of the non-motor symptoms observed in PD patients, with a comparative analysis between patients with and without peripheral neuropathy, to explore the relationships between peripheral neuropathy and non-motor symptoms.Methods100 PD patients were recruited from the Neurology Department of Guangdong Provincial People's Hospital.
View Article and Find Full Text PDFJACC Adv
August 2025
Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut, USA; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA; Center for Infection and Immunity, Yale School of Medicine, New Haven, Connect
Background: Postural orthostatic tachycardia syndrome (POTS) has emerged as a significant cardiovascular phenotype among individuals experiencing postacute COVID-19 syndrome, commonly referred to as long COVID.
Objectives: The purpose of this study was to describe the experience of people reporting long COVID-associated POTS.
Methods: We collected data from individuals aged ≥18 years with self-reported long COVID who participated in the Yale Listen to Immune, Symptom and Treatment Experiences Now (LISTEN) cohort, an online observational study.
Toxins (Basel)
August 2025
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
Tremor, an oscillatory movement disorder, is commonly encountered in clinical practice in the setting of a variety of etiologies, such as essential tremor and Parkinson's disease. Despite its high prevalence, treatment options are somewhat limited. Oral medications are often ineffective or limited by side effects, and other treatments, such as deep brain stimulation, are more invasive and costly.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Department of Pathophysiology, American University of Antigua, Osbourn, Antigua and Barbuda.
Rationale: Adaptive deep brain stimulation (aDBS) represents a notable advancement in treating Parkinson's disease (PD), as it offers enhanced therapeutic outcomes and personalized management by adjusting stimulation parameters in real-time according to individual neural signals. This approach minimizes adverse effects commonly associated with standard continuous deep brain stimulation (cDBS). This case report describes the progress of a 62-year-old man with severe PD who demonstrated notable enhancement in motor symptoms and quality of life throughout a 3-month trial period using aDBS.
View Article and Find Full Text PDF