Ketogenic diet and quercetin promote the recovery of motor function in rats with spinal cord injury.

Spinal cord injury (SCI) is a devastating neurological disorder, and currently, there are no effective therapeutic options to promote the recovery of motor function. Therefore, exploring safe and effective post-SCI repair strategies is crucial. In our study, we investigated the therapeutic effects of ketogenic diet (KD) and quercetin, both separately and in combination, on the recovery of motor and neurological functions in rats with SCI.

Photonic Boosting of Lattice Oxygen Mobility in Rh-Mn/CoAlO Heterostructure Catalysts to Enhanced CO-SCR Catalytic Performance.

Developing efficient low-temperature selective catalytic reduction (CO-SCR) catalysts remains a key challenge in reducing nitrogen oxide (NO) emissions. Here, we report a photothermal-enhanced Rh-Mn/CoAlO heterostructure catalyst that achieves excellent NO conversion (more than 90% at 140 °C) and N selectivity (>80%) under visible to infrared light irradiation. By integration of highly dispersed Rh units with Mn clusters onto a hydrotalcite-derived CoAlO support, the catalyst exhibits synergistic light absorption and dynamic lattice oxygen migration capabilities.

HqHBP, a histamine-binding protein derived from the hard tick Haemaphysalis qinghaiensis, alleviates xylene-induced mice skin edema.

As one of the most important blood-sucking parasites, ticks can secrete various biological molecules to counteract responses such as hemostasis and inflammation in their host during the blood-feeding process. A cDNA clone named as Hq018 was identified from a salivary gland cDNA expression library of Haemaphysalis qinghaiensis. A protein consisting of 217 amino acids with a molecular mass of 24.

Prevalence of oral human papILLOmavirus infection among adult men and women in Taiwan (PILLOT).

Objectives: Persistent oral human papillomavirus (HPV) infection, a key risk factor for head and neck cancers, is well-studied in Western populations but less understood elsewhere. This study aimed to estimate the prevalence of oral HPV infection by genotype among Taiwanese adults, stratified by sex and age, and identify associated risk factors.

Methods: This cross-sectional study included adults aged 20-60 years who visited Otorhinolaryngology departments at six medical centers in Taiwan (September 2021-October 2022).

Macrophage-derived dendritic cells enhance antitumor immunity in a mouse model of head and neck squamous cell carcinoma.

Purpose: This study investigates the therapeutic potential of bone marrow macrophages-derived dendritic cells (BMΦDCs) in enhancing antitumor immunity against head and neck squamous cell carcinoma (HNSCC), focusing on their effects in inhibiting tumor growth, reducing metastasis, and modulating the tumor microenvironment.

Methods: BMΦDCs were generated by culturing bone marrow cells with macrophage colony-stimulating factor (M-CSF) followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4). MTCQ-1 tumor lysates were used for antigen loading.

New insights into DEHP-induced inflammatory injury in chicken spleen: ROS/TLR4/MyD88 pathway and apoptosis/necroptosis-M1 polarization crosstalk.

The environmental endocrine disruptor di(2-ethylhexyl) phthalate (DEHP) is a plasticiser used in large quantities in plastics and is hazardous to the health of humans and various animals. DEHP can be immunotoxic to the spleen through oxidative stress. Still, the role of splenic macrophage polarization in lymphocyte apoptosis and necroptosis, whether they interact with each other, and the mechanism of the effect on splenic inflammatory injury are unknown.

Hierarchy Reproduction: Multiphasic Strategies for Tendon/Ligament-Bone Junction Repair.

Tendon/ligament-bone junctions (T/LBJs) are susceptible to damage during exercise, resulting in anterior cruciate ligament rupture or rotator cuff tear; however, their intricate hierarchical structure hinders self-regeneration. Multiphasic strategies have been explored to fuel heterogeneous tissue regeneration and integration. This review summarizes current multiphasic approaches for rejuvenating functional gradients in T/LBJ healing.

Modulating tumor-associated macrophages through CSF1R inhibition: a potential therapeutic strategy for HNSCC.

Purpose: Tumor-associated macrophages (TAMs) are pivotal immune cells within the tumor microenvironment (TME), exhibiting dual roles across various cancer types. Depending on the context, TAMs can either suppress tumor progression and weaken drug sensitivity or facilitate tumor growth and drive therapeutic resistance. This study explores whether targeting TAMs can suppress the progression of head and neck squamous cell carcinoma (HNSCC) and improve the efficacy of chemotherapy.

Qinghaienin, a novel anticoagulation protein from the hard tick Haemaphysalis qinghaiensis, inhibits the activation of factor XII by competing for anionic surfaces.

Salivary proteins of ticks can inhibit host hemostatic and inflammatory responses during the blood-sucking process of the parasites. A cDNA sequence, Hq021, was identified from a cDNA library of Haemaphysalis qinghaiensis. Hq021 encodes a mature protein containing 182 amino acids with a molecular mass of 20.

A novel Diguanylate cyclase VdcR has multifaceted regulatory functions in the pathogenicity of Vibrio vulnificus.

Background: Vibrio vulnificus is a Gram-negative pathogen that infects humans through foodborne or wound infections. Victims of V. vulnificus infections face significant health risks, including cellulitis and septicemia, which have rapid disease progression and high mortality rates.

Asymmetric oxygen vacancy promotes CO-SCR performance on defect-engineered Rh/CeCuO catalyst.

Selective catalytic reduction of NO with CO (CO-SCR) is a process that purifies both NO and CO pollutants through a catalytic reaction. Specifically, the cleavage of NO on the catalyst surface is crucial for promoting the reaction. During the reaction, the presence of oxygen vacancies can extract oxygen from NO, thereby facilitating the cleavage of NO on the catalyst surface.

Risk factors of chronic endometritis in women who have undergone hysteroscopy: a prospective nested case-control study.

There is limited research on risk factors for chronic endometritis regarding reproductive history and clinical symptoms. Thus, this nested case-control study identified risk factors for chronic endometritis in women who have undergone hysteroscopy. Endometrial tissue sections were obtained from 502 women with intrauterine disorders who underwent hysteroscopy.

Identification of a novel protein Hq023 of the hard tick Haemaphysalis qinghaiensis and preliminary evaluation of its analgesic effect in mice model.

Tick saliva contains a range of critical biological molecules which could inhibit host defenses and guarantee their food supply. Hq023, a novel cDNA sequence, was cloned from a cDNA library constructed from salivary glands of partially-engorged Haemaphysalis qinghaiensis. Hq023 has an open reading frame (ORF) of 408 bp coding a protein containing 135 amino acid residues with a molecular mass of 15 kDa.

Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways.

Objective: This study is designed to investigate the mode of action of the synergistic effect of 5-fluorouracil (5-FU) and magnolol against cervical cancer.

Methods: Network pharmacological approach was applied to predict the molecular mechanism of 5-FU combined with magnolol against cervical cancer. CCK-8 assay, colony formation assay, immunofluorescence staining, adhesion assay, wound healing mobility assay, cell migration and invasion assay and Western blot analysis were conducted to validate the results of study.

GxE interaction effects of single nucleotide polymorphism and adverse childhood experiences on methamphetamine use disorder.

Methamphetamine use disorder (MUD) is a worldwide health concern. The hypothalamic orexin system regulates stress response and addictive behaviors. The genetic variation in the hypocretin receptor 2 (HCRTR2), rs2653349, is associated with substance use disorder.

Design, synthesis, and biological evaluation of tetrahydroquinoline amphiphiles as membrane-targeting antimicrobials against pathogenic bacteria and fungi.

The rising prevalence of drug-resistant pathogens is one of the biggest threats to human health. The development of new antibiotics that can overcome drug resistance is in urgent need. Herein, we designed and synthesized a series of amphiphilic tetrahydroquinoline derivatives as small-molecule-based antimicrobial peptidomimetics.

Distribution of Yeast Species and Risk Factors of Oral Colonization after Oral-Care Education among the Residents of Nursing Homes.

Most yeasts causing infections in humans are part of commensal microflora and etiological agents of different infections when hosts become susceptible, usually due to becoming immunocompromised. The colonization of potentially pathogenic microbes in the oral cavity is increased by poor oral hygiene. This follow-up survey was conducted approximately two months after providing information on proper oral care at 10 nursing homes in Taiwan.

Resveratrol Ameliorates High-Fat-Diet-Induced Abnormalities in Hepatic Glucose Metabolism in Mice via the AMP-Activated Protein Kinase Pathway.

Diabetes mellitus is highly prevalent worldwide. High-fat-diet (HFD) consumption can lead to liver fat accumulation, impair hepatic glycometabolism, and cause insulin resistance and the development of diabetes. Resveratrol has been shown to improve the blood glucose concentration of diabetic mice, but its effect on the abnormal hepatic glycometabolism induced by HFD-feeding and the mechanism involved are unknown.

Thermal treatment enhances the α-glucosidase inhibitory activity of bitter melon (Momordica charantia) by increasing the free form of phenolic compounds and the contents of Maillard reaction products.

Inhibition of α-glucosidase can slow carbohydrate metabolism, which is known as an effective strategy for diabetes treatment. The aim of this study is to evaluate the effect of thermal treatment (50, 60, and 70℃) for 15 days on the α-glucosidase inhibitory activity of bitter melon. The results show that the bitter melon heated at 70℃ for 12 days had the best α-glucosidase inhibitory effect.

Development of BRAF V600E Mutation in NRAS Q61L Mutated Rectal Cancer.

BRAF and NRAS are oncogenes in the RAS/RAF/MEK/MAP-kinase signaling pathway. Coexistent mutations of BRAF and NRAS in a single colorectal cancer patient have always been considered mutually exclusive or at least rare. The clinical outcome of these patients remains undetermined.