PRMT5 encourages cell migration and metastasis of tongue squamous cell carcinoma through methylating ΔNp63α.

Tongue squamous cell carcinoma (TSCC) is a common oral malignancy prone to metastasis, whose underlying mechanism remains obscure. Here, we report the oncogenic roles of protein arginine methyltransferase 5 (PRMT5) in TSCC via inhibiting transcription factor ΔNp63α. We found that PRMT5 physically interacts with ΔNp63α, resulting in impairment of ΔNp63α-mediated transcriptional regulation.

Crosstalk between ROS and Ferroptosis, Cuproptosis, and PANoptosis in Liver Cancer: Mechanisms and Therapeutic Strategies.

Hepatocellular carcinoma (HCC) is a common and complex malignant tumor whose etiology is influenced by a variety of factors and exhibits different outcomes during disease progression. HCC is distinguished by the triggering of various cell death pathways, for example ferroptosis, cuproptosis, and PANoptosis. This review provides insights into the current understanding of the interactions between reactive oxygen species (ROS) and these novel mechanisms of cell death in HCC, highlighting their significance in disease pathogenesis and their potentiality as therapeutic goals.

Simple Two-Component CDs/PVA Hydrogels Possess Dynamic High-Definition and Two-Stage Information Encryption Capability.

Ensuring the fidelity and security level of stored information is essential for information carrier materials to safeguard data and prevent counterfeiting. However, low resolution, limited encryption modes, and complex fabrication hinder existing information carriers from meeting evolving technological demands. Herein, a solvent exchange strategy from DMSO to water is employed to stably anchor hydrophobic fluorescent carbon dots (CDs) with multiple emission states onto a 3D framework of poly(vinyl alcohol) (PVA) chains, forming a simple two-component CDs/PVA hydrogel with tunable fluorescent colors and recyclability.

Mechanism studies on α-glucosidase inhibition and glycemic regulation of inotodiol from Inonotus obliquus.

Inonotus obliquus is a medicinal fungus that has been valued for its anti-diabetic properties in China for thousands of years. Inotodiol is a characteristic triterpenoid isolated from Inonotus obliquus. The inactivation effect and mechanism of α-glucosidase induced by inotodiol were investigated using fluorescence, FTIR, CD spectroscopy, and molecular dynamics simulation, and the glycemic regulation of inotodiol was studied on insulin-resistant HepG2 cells.

Rational module substitution strategy to enhance ACE-inhibitory peptide activity.

Food-derived angiotensin-converting enzyme (ACE)-inhibitory peptide plays key roles in hypertension prevention, however, their activity is dependent on specific sequence composition. This study aims to enhance peptide activity using a module substitution strategy. Molecular docking and activity assays identified MF as a low- and FP as a high-contribution dipeptide module within MFPWP.

Correction: Preexisting statin therapy is not associated with reduced acute kidney injury following cardiac surgery: a retrospective analysis.

[This corrects the article DOI: 10.3389/fphar.2025.

The role of miR-10b-5p in prostate cancer and its exosome-mediated angiogenesis effect.

Objective: Prostate cancer (PCa) continues to be a major cause of cancer-related mortality globally, underscoring the critical need for novel therapeutic strategies. This study investigates the oncogenic function of miR-10b-5p in PCa progression and evaluates its potential as both a diagnostic marker and therapeutic target.

Methods: miR-10b-5p was initially identified as a candidate oncogene through bioinformatic analysis of The Cancer Genome Atlas (TCGA) PCa data, followed by validation of its expression levels in clinical PCa specimens via fluorescence in situ hybridization (FISH).

Modified Endoscopic Biliary Stent Combined with Photodynamic Therapy: A New Strategy for the Palliative Treatment of Extrahepatic Cholangiocarcinoma.

Photodynamic therapy (PDT) combined with biliary stenting reportedly has better efficacy and safety in the treatment of extrahepatic cholangiocarcinoma (EHC). Considering the shortcomings of traditional PDT methods, we proposed a novel modified approach, defined as initial biliary stent placement followed by PDT, for the treatment of EHC. The study aimed to evaluate the effect and safety of biliary stent placement prior to PDT versus only stent placement on the treatment of EHC.

Beyond Density: Unveiling the Trade-Off in Catalytic Site Optimization Using Defect-Engineered UiO-66.

Enhancing intrinsic activity and increasing catalytic site density are two widely employed strategies to improve catalytic performance. Although typically considered independently, their interplay remains poorly understood. Here, two UiO-66 metal-organic frameworks (MOFs) with distinct catalytic site densities-linker-defective UiO-66L and cluster-defective UiO-66C-are synthesized and systematically compared.

Methanotroph () bacteria meal, influences the intestinal microbiome, and improves intestinal barrier function and immunity in hybrid grouper ( ♀ × ♂).

The hybrid grouper () is an important aquaculture marine species in China. The current study was designed to test the effects of methanotroph () bacteria meal (MBM) on hybrid grouper growth and intestinal health outcomes. Five iso-nitrogenous and iso-lipidic diets were formulated, comprising a control diet (MBM0) with 400 g/kg fish meal (FM) as the main protein source, and four experimental diets, in which FM was replaced at 5% (MBM2), 10% (MBM4), 20% (MBM8) and 30% (MBM12) with 20, 40, 80 and 120 g/kg of MBM, respectively.

Senescent Cancer Cells in Immune Surveillance and Evasion: Mechanisms and Therapeutic Implications.

Cellular senescence is a stress-induced program characterized by long-lasting cell cycle arrest and the secretion of bioactive and inflammatory molecules, which are collectively referred to as the senescence-associated secretory phenotype (SASP). Diverse stressors, including oncogene activation, chemotherapy, radiotherapy, and cytokine exposure, can induce cellular senescence in cancer cells. Senescent cancer cells (SnCs) can enhance immune responses and promote tumor immune surveillance.

Disulfidptosis-associated gene signature predicts prognosis and radioresistance in NSCLC.

Background: NSCLC has an extremely high mortality rate, and limitations exist in the efficacy of current therapeutic modalities and the choice of treatment strategies. Cells overexpressing cystine/glutamate transporter proteins and experiencing a glucose shortage could lead to NADPH deficiency and excessive disulfide buildup, causing stress responses and cell death, which affects patient's prognosis.

Methods And Materials: Based on TCGA and GEO datasets, consensus clustering of NSCLC patients was performed to identify disulfidptosis-related genes and construct a prognostic model.

Characteristics of heavy metal element content and health risk assessment in groundwater in Zhaojue area, Sichuan Province, China.

Groundwater serves as the primary drinking water source for residents in the Zhaojue area, located in the hinterland of the Daliang Mountains in Sichuan Province. This study investigated the spatial distribution, pollution characteristics, and health risks of 10 metal elements (As, Cd, Al, Mn, Hg, Co, Cu, Pb, Zn, Ni) through 48 groundwater sampling sites. Comprehensive analysis using single-factor and Nemerow composite pollution index evaluation methods, coupled with multivariate statistics and health risk models, revealed critical findings.

An Efficient Manufacturing Method for Silicon Carbide Crystals in Polymers Based on a Multiscale Simulation-Driven Approach.

The pyrolysis of polydimethylsiloxane (PDMS) for silicon carbide (SiC) fabrication endows precursor materials with exceptional microstructural controllability and complex geometry retention capability, rendering it widely applicable in flexible electronic packaging and microscale complex-structured heat exchangers. Nevertheless, the widespread adoption of pyrolytic SiC has been constrained by the low yield and process complexity inherent to conventional pyrolysis methods. In response, we developed a multiscale simulation framework integrating macroscopic thermal distribution with microscopic chemical reaction kinetics.

Pathway analysis of nursing interns' professional benefit perception and influencing factors: a cross-sectional study.

Aim: This study aims to examine the current professional benefit perception among nursing interns and explore their interactions with perspective taking, compassion satisfaction, and secondary traumatic stress.

Background: The professional benefit perception is a crucial determinant in the career decisions of nursing interns. Understanding the pathways through which various factors influence this perception can inform the development of targeted intervention strategies.

Formation of thiocarbonic acid (HCS) - the sulfur counterpart of carbonic acid (HCO) - in interstellar analog ices.

The first experimental formation of thiocarbonic acid (HCS) is presented in this work from low-temperature interstellar ice analogs composed of hydrogen sulfide (HS) and carbon disulfide (CS) exposed to electron irradiation simulating the impact of galactic cosmic rays (GCRs) on interstellar ices. The recent attention brought to sulfur-bearing molecules, as well as the recent detection of carbonic acid (HCO) in the interstellar medium (ISM), invites the study of the interstellar detection of the sulfur counterpart, thiocarbonic acid. However, the interstellar formation pathways of thiocarbonic acid have remained elusive.

Deep generative models design mRNA sequences with enhanced translational capacity and stability.

Despite the success of mRNA COVID-19 vaccines, extending this modality to more diseases necessitates substantial enhancements. We present GEMORNA, a generative RNA model that utilizes Transformer architectures tailored for mRNA coding sequences (CDSs) and untranslated regions (UTRs), to design novel mRNAs with enhanced expression and stability. GEMORNA-designed full-length mRNAs exhibited up to a 41-fold increase in firefly luciferase expression compared to an optimized benchmark in vitro.

Bidirectional Beta-Tuned Diffusion Model.

Diffusion models have gained significant attention in the field of generative modeling due to their capability to produce high-quality samples. However, recent studies show that applying a uniform treatment to all distributions during the training of diffusion models is sub-optimal. In this paper, we present a comprehensive theoretical analysis of the forward process in diffusion models.

Factors Influencing Hormone Remission in Growth Hormone-Secreting Pituitary Neuroendocrine Tumors With Residual Tumor: A Retrospective Cohort Study.

Background: Growth hormone-secreting pituitary neuroendocrine tumors (GH-secreting PitNETs) pose significant health risks due to hormone-related complications. Despite transsphenoidal surgical resection being the primary treatment, complete removal is often infeasible due to invasive growth patterns, leading to postoperative tumor residuals and uncertain hormone remission outcomes.

Methods: This retrospective study included 458 patients with GH-secreting PitNETs who underwent surgery at Beijing Tiantan Hospital.

Cyclin-dependent kinase 1 (CDK1) in cancers: from upstream regulation to downstream substrates and therapeutic inhibitors.

Cyclin-dependent kinase 1 (CDK1) is a pivotal regulator of cell cycle progression. Mounting documents indicate the complicated roles of this kinase in various malignancies. Here, we roundly overview the regulation of CDK1 in malignancies, and find that CDK1 is widely upregulated in diverse cancers at either expression or enzymatic activity levels.

Significant adverse prognostic events in patients with urosepsis: a machine learning based model development and validation study.

Background: Urosepsis is a subset of sepsis with a high mortality rate. Currently, the ranking of urosepsis in sepsis etiology is on the rise. Our goal is to use machine learning (ML) methods to construct and validate an interpretable prognosis prediction model for patients with urosepsis.

Study on the mechanism of anti-pulmonary fibrosis action of amygdalin based on transcriptomics and metabolomics.

Pulmonary fibrosis (PF) is closely associated with many chronic lung diseases. Amygdalin has antitussive and asthmatic properties and may play a role in intervening in PF. This study was to investigate the effects of amygdalin on bleomycin-induced PF in rats by integrating pharmacodynamics, transcriptomics, and untargeted metabolomics.

Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors.

Solitary fibrous tumors (SFTs) of the central nervous system (CNS) are rare, aggressive mesenchymal neoplasms with high recurrence and metastasis rates. Here, we perform a comprehensive multi-omics analysis of 189 cases of CNS SFTs integrating 94 whole genome sequencing, 88 transcriptomics, 7 single-nucleus RNA sequencing and 3 spatial transcriptome sequencing. We find that receptor tyrosine kinase mutations are significantly more prevalent besides the widespread NAB2-STAT6 fusion and correlate with tumor grade.