Senescent Cancer Cells in Immune Surveillance and Evasion: Mechanisms and Therapeutic Implications.

Cellular senescence is a stress-induced program characterized by long-lasting cell cycle arrest and the secretion of bioactive and inflammatory molecules, which are collectively referred to as the senescence-associated secretory phenotype (SASP). Diverse stressors, including oncogene activation, chemotherapy, radiotherapy, and cytokine exposure, can induce cellular senescence in cancer cells. Senescent cancer cells (SnCs) can enhance immune responses and promote tumor immune surveillance.

Examining the validity and reliability of the revised developmental work personality scale (RDWPS)-traditional Chinese version.

Background: Work personality was found to relate to successful work adjustment, job readiness, work motivation and job maintenance. The revised developmental work personality scale (RDWPS) is a self-reported assessment to evaluate the work personality of the examinee which further psychometric study is required and needs to be applied to different culture. The aim of this study was to examine the theoretical structure, validity, and reliability of the traditional Chinese version of the RDWPS.

[Effectiveness analysis of surgical treatment of Schatzker type tibial plateau fractures].

Objective: To introduce a surgical protocol based on the location and orientation of the apex of the medial condylar fracture line for the treatment of Schatzker type Ⅳ tibial plateau fractures and report the preliminary effectiveness.

Methods: The clinical data of 18 patients with Schatzker type Ⅳ tibial plateau fractures underwent open reduction and internal fixation between March 2012 and April 2016 were retrospectively analysed. There were 6 males and 12 females, aged 36-74 years (mean, 45 years).

[IMPROVED DOUBLE OPERATIVE APPROACHES FOR TREATMENT OF Pilon FRACTURES ACCOMPANIED WITH FIBULA FRACTURES].

Objective: To investigate the clinical effect of surgical treatment of Pilon fractures accompanied with fibula fractures with the improved double operative approaches.

Methods: Between January 2012 and June 2015, 19 patients with closed Pilon fractures accompanied with fibula fractures (Rüedi-Allgöwer type Ⅲ) underwent open reduction and internal fixation with improved anterior-median incision and posterior-lateral incision. There were 13 males and 6 females, aged 35 years on average (range, 23-68 years).

Successful salvage of the upper limb after crush injury requiring nine operations: a case report.

Emergency treatment of amputation is one of the most frequently used therapeutic methods for patients with severe upper limb crush injury with a mangled extremity severity score (MESS) of more than 7. With the development of advanced surgical repair techniques and reconstructive technology, cases that once required amputation can now be salvaged with appropriate management, and some limb functions may also be reserved. A patient with a severe upper limb crush injury with a MESS score of 10 was treated in our hospital.

The downregulation of miR-144 is associated with the growth and invasion of osteosarcoma cells through the regulation of TAGLN expression.

Alterations in the expression of microRNAs (miRNAs or miRS) have been implicated in the pathogenesis of the majority of human malignancies, and the dysregulation of microRNA-144 (miR-144) has been associated with several diseases. However, the potential involvement of miR-144 in osteosarcoma, a common malignant bone tumor in children and adolescents with a high risk of relapse and metastasis, has not yet been fully investigated. In the present study, we examined the expression and roles of miRNAs in osteosarcoma as potential diagnostic markers and therapeutic targets, and we focused on miR-144 due to its known involvement in osteogenesis.

Chondrogenic differentiation of human mesenchymal stem cells cultured in a cobweb-like biodegradable scaffold.

Human mesenchymal stem cells (MSCs) were cultured in vitro in a cobweb-like biodegradable polymer scaffold: a poly(dl-lactic-co-glycolic acid)-collagen hybrid mesh in serum-free DMEM containing TGF-beta3 for 1-10 weeks. The cells adhered to the hybrid mesh, distributed evenly, and proliferated to fill the spaces in the scaffold. The ability of the cells to express gene encoding type I collagen decreased, whereas its ability to express type II collagen and aggrecan increased.

[Experimental investigation on sulfur emission properties of micro-pulverized coal].

Micro-pulverized coal(0-20 microns) combustion is a new kind of pulverized coal combustion technology. Four Heshan sulfur coal samples with different mean particles diameter were combusted, using a TGA-FTIR made in Germany. Micro-pulverized coal self-desulfurization and adding CaO desulfurization characteristics were investigated.