Senescent Cancer Cells in Immune Surveillance and Evasion: Mechanisms and Therapeutic Implications.

Cellular senescence is a stress-induced program characterized by long-lasting cell cycle arrest and the secretion of bioactive and inflammatory molecules, which are collectively referred to as the senescence-associated secretory phenotype (SASP). Diverse stressors, including oncogene activation, chemotherapy, radiotherapy, and cytokine exposure, can induce cellular senescence in cancer cells. Senescent cancer cells (SnCs) can enhance immune responses and promote tumor immune surveillance.

Temporal miRNA Biomarkers for Pupal Age Estimation in (Diptera: Sarcophagidae).

The pupal stage in necrophagous flies represents the longest and least morphologically distinct phase of development, posing a persistent challenge for accurately estimating postmortem intervals (PMI) in forensic investigations. Here, we present a novel molecular approach to pupal age estimation in , a forensically important species, by profiling microRNA (miRNA) expression dynamics. High-throughput sequencing across early, mid, and late pupal stages identified 191 known miRNAs, of which nine exhibited distinct monotonic temporal trends.

Unsupervised 3D Object Detection by Commonsense Clue.

Traditional 3D object detectors, whether fully-, semi-, or weakly-supervised, rely heavily on extensive human annotations. In contrast, this paper introduces an unsupervised 3D object detector that automatically discerns object patterns without such annotations. To achieve this, we propose a Commonsense Prototype-based Detector (CPD) for unsupervised 3D object detection.

Air Pollution, Genetic Susceptibility, and Risk of Symptomatic Peripheral Arterial Disease: A Cohort Study of the UK Biobank.

Objective: This study aimed to investigate the relationship between exposure to various air pollutants and the risk of symptomatic peripheral arterial disease (PAD) and to explore whether the association is modified by genetic predisposition to PAD.

Methods: A prospective cohort study was conducted using data from the UK Biobank. The analysis included individuals without a history of PAD at baseline and with available data for air pollutants and covariates.

Assessing the influence of male vaccination on cervical cancer elimination in China under different vaccination coverage scenarios: A modeling study.

Cervical cancer caused by human papillomavirus (HPV) infection remains a significant public health challenge in China, where screening and HPV vaccination uptake fall well below World Health Organization's (WHO) targets. This study aimed to assess the impact of gender-neutral vaccination (GNV) on cervical cancer elimination in China at a range of vaccination coverage rates (VCRs) and screening uptake rates. Using a model to project cervical cancer incidence and cases in China over 100 years, we evaluated different vaccination strategies using either a bivalent (2vHPV) or nonavalent (9vHPV) vaccine and estimated the time taken to reach the WHO's elimination threshold of 4 cases per 100,000 women.

Overcoming multidrug resistance in gastrointestinal cancers with a CDH17-targeted ADC conjugated to a DNA topoisomerase inhibitor.

Cadherin 17 (CDH17) has emerged as a promising target for gastrointestinal (GI) cancers, which are often complicated by multidrug resistance (MDR) and recurrence. In this study, we developed 7MW4911, a CDH17-targeted antibody-drug conjugate (ADC) that incorporates a topoisomerase inhibitor MF-6 (Topi MF-6) payload linked via a cleavable linker, designed specifically to address MDR in GI cancers. 7MW4911 exhibited high specificity for CDH17-expressing cancer cells and potent cytotoxicity in vitro.

Chronofluorometry Based on a Facile Fluorescent Probe for Rapid Detection of Fractional Exhaled Nitric Oxide and Bioimaging in Live Cells.

Fractional exhaled nitric oxide (FeNO) is an established biomarker of type 2 airway inflammation in asthma. The advancement of rapid and sensitive FeNO detection technology is crucial for improving the diagnosis and treatment of patients with asthma or airway inflammation. In this study, we introduce chronofluorometry as a novel method for quantitative analysis using specifically designed and synthesized fluorescent probes.

Faecalibacterium Prausnitzii extracellular vesicles regulating macrophage differentiation via homologous recombination repair in colitis model.

Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation influenced by the depletion of beneficial gut microbiota, a critical factor in disease onset and progression. This study investigates the therapeutic potential of extracellular vesicles (EVs) derived from Faecalibacterium prausnitzii (F.p EVs), a commensal bacterium whose reduction is linked to IBD.

Phenotypic diversity of Pennisetum centrasiaticum germplasms in the upper and middle reaches of the Yarlung Zangbo river.

Pennisetum centrasiaticum is a perennial grass that exhibits a broad distribution in the upper and middle reaches of the Yarlung Zangbo River. It can provide forage for animals and has high ecological value. In this study, 26 communities of P.

Research on rock burst prediction based on an integrated model.

Rockburst is a significant safety threat in coal mining, influenced by complex nonlinear dynamic characteristics and multi-factor coupling. This study proposes a rockburst risk prediction method based on the SSA-CNN-MoLSTM-Attention model. The model integrates the local feature extraction capability of convolutional neural networks (CNN), the temporal modeling advantages of the modified long short-term memory network (MoLSTM), and the enhanced feature recognition capability of the attention mechanism.

Long-term outcomes of additional surgery vs. observation after noncurative endoscopic submucosal dissection for early gastric cancer and application value of the eCura scoring system: a propensity score-matched study.

Background: Endoscopic submucosal dissection (ESD) is increasingly used for treating early gastric cancer (EGC). Noncurative ESD often necessitates additional surgical intervention because of the high risk of lymph node metastasis (LNM), but the optimal post-ESD management remains controversial.

Methods: This study collected data from patients with EGC who underwent noncurative ESD at Nanjing Drum Tower Hospital between January 2014 and December 2021.

Identification of circular RNAs as biomarkers for pupal age estimation and postmortem interval in forensically important Sarcophaga peregrina (Diptera: Sarcophagidae).

Accurate estimation of the pupal age in necrophagous flies is vital for determining the postmortem interval (PMI) in forensic entomology. Differential expression of genes (DEGs) exhibits temporal fluctuations across the developmental stages of these flies. This study evaluates circular RNAs (circRNAs) as novel molecular markers and develops a model for predicting pupal development time based on circRNA expression.

Protein-inorganic hybrid flowers with a two-stage accelerated strategy for stimulated activation of CRISPR/Cas12a enhance polynucleotide kinase biosensing.

Polynucleotide kinases (PNK) play a crucial role in DNA damage repair and are closely associated with specific diseases, making them promising targets for therapeutic intervention. In this study, we propose a two-stage accelerated strategy that utilizes protein-inorganic hybrid flowers (PHFs) to enhance the performance of the terminal deoxynucleotidyl transferase (TdT)-combined CRISPR/Cas12a system (TCS) for efficient detection of PNK activity. In TCS, the participation of PHFs confines the substrate probes (SPs) to a limited space, thereby significantly enhancing the local concentration of phosphorylated 3' termini of SPs and effectively promoting the enzymatic reaction kinetics as the first step in the accelerated strategy.

Intralobar pulmonary sequestration complicated by a giant supplying artery aneurysm presenting for 9 years: a case report.

Background: This article reports a case of a intralobar pulmonary sequestration (IPS) with a significantly large feeding artery aneurysm and shares the successful treatment experience.

Case Presentation: A male was diagnosed with IPS combined with a feeding artery aneurysm approximately 74 mm × 61 mm in nine years ago but refused thoracotomy at that time. The patient presented this time due to an infection, and a CT scan revealed a significant increase in the lesion size to approximately 123 mm × 100 mm.

N/O co-doping porous biomass carbon constructed electrochemical sensor for universal and sensitive detection to mycotoxins.

Mycotoxin contamination poses a great threat to food safety and human health. Thus, universal and sensitive detection of mycotoxins is urgently needed. Herein, N/O co-doped porous biomass carbon was synthesized from rice straw as a novel electrode modification material for fabricating an electrochemical sensor for mycotoxin detection.

Dynamic physiology and transcriptomics revealed the alleviation effect of melatonin on under continuous alkaline salt stress.

Introduction: , a pivotal salt-tolerant plant species in Central Asian salt desert ecosystems, has garnered significant attention due to its resilience under harsh environmental conditions. This study investigates the response mechanisms of melatonin on the dynamic physiology and transcriptomics of , a critical salt-tolerant plant species in Central Asian salt desert ecosystems. Despite significant progress in understanding plant salt tolerance, research on the positive effects of melatonin on , particularly its impact on seed germination and the underlying physiological and molecular mechanisms, remains limited.

A deep-learning system integrating electrocardiograms and laboratory indicators for diagnosing acute aortic dissection and acute myocardial infarction.

Background: Acute Stanford Type A aortic dissection (AAD-type A) and acute myocardial infarction (AMI) present with similar symptoms but require distinct treatments. Efficient differentiation is critical due to limited access to radiological equipment in many primary healthcare. This study develops a multimodal deep learning model integrating electrocardiogram (ECG) signals and laboratory indicators to enhance diagnostic accuracy for AAD-type A and AMI.

C118P Suppresses Gastric Cancer Growth via Promoting Autophagy-Lysosomal Degradation of RAB1A.

: Gastric cancer (GC) is the leading cause of cancer-related deaths worldwide. C118P, a microtubule inhibitor with anti-angiogenic and vascular-disrupting activities, was proven to be cytotoxic to various cancer cell lines. This study aimed to explore the anti-tumor effect of C118P against gastric cancer and identify its potential target.

Analysis of MRI imaging characteristics in 10 cases of adult granulosa cell tumor with normal estrogen levels.

Objective: This study investigates the MRI characteristics of primary and metastatic adult granulosa cell tumor with normal estrogen levels (AGCT-NEL) to enhance clinical understanding and diagnostic accuracy of this disease.

Methods: We collected clinical data from 10 patients with AGCT-NEL, confirmed by pathology, treated at our hospital from January 2016 to January 2024. We retrospectively analyzed the MRI features of primary and metastatic lesions from aspects such as shape, edge characteristics, MRI signal, and enhancement features.

A consensus platform for antibody characterization.

Antibody-based research applications are critical for biological discovery. Yet there are no industry standards for comparing the performance of antibodies in various applications. We describe a knockout cell line-based antibody characterization platform, developed and approved jointly by industry and academic researchers, that enables the systematic comparison of antibody performance in western blot, immunoprecipitation and immunofluorescence.

Netupitant Inhibits the Proliferation of Breast Cancer Cells by Targeting AGK.

: Currently, there is a significant lack of effective pharmacological agents for the treatment of breast cancer. Acylglycerol Kinase (AGK), a lipid kinase, has been found to be aberrantly expressed in breast cancer and is closely associated with tumor proliferation, migration, and invasion. However, no clinical anti-tumor drugs specifically targeting this kinase have been developed.

Efficient Elimination of Inorganic/Organic Pollutants by FeO/biochar@sodium Alginate Gel Beads.

The magnetic composite gel bead (FeO-C@SA GB) adsorbent was prepared by sodium alginate (SA) crosslinking with pitaya peel-derived porous carbons (PPDPCs) and magnetic iron oxide nanoparticles (FeO NPs). The adsorption effects of FeO-C@SA GBs on heavy metal ions (HMIs) and 17 β-estradiol (E2) in water are evaluated by classical kinetic models and isotherm models. The pseudo-second-order kinetic model shows that FeO-C@SA GBs have maximum adsorption capacities of 9.

Analysis of the correlation between Hashimoto's thyroiditis and food intolerance.

Objective: This study aims to explore the correlation between patients with Hashimoto's thyroiditis and food intolerance.

Methods: A total of 172 subjects who visited Guangdong Provincial Hospital of Traditional Chinese Medicine between January 2020 and March 2023 were selected and tested for 90 food-specific IgG antibodies. The study group composed 85 individuals diagnosed with Hashimoto's thyroiditis, while the control group consisted of 87 healthy individuals.

Caveolin-1 modulates cisplatin sensitivity in oral squamous cell carcinoma through ferroptosis.

Objective: Cisplatin-based chemotherapy is widely used for the treatment of oral squamous cell carcinoma (OSCC), but drug resistance and decreased sensitivity often occur during the treatment, greatly weakening its therapeutic effect. Caveolin-1 (CAV1), a protein related to ferroptosis, is involved in regulating the resistance and sensitivity of various tumor chemotherapies. This study aims to investigate whether CAV1 can regulate the sensitivity of OSCC to cisplatin through ferroptosis.