Global and Regional Burden of Periodontal Disease in Adults (1990-2021).

Background: Periodontitis is one of the most prevalent chronic inflammatory diseases globally, characterised by progressive destruction of tooth-supporting structures. It has significant implications for oral health and has been associated with systemic conditions such as cardiovascular disease, diabetes and respiratory infections. Despite ongoing public health initiatives, periodontitis remains a substantial burden worldwide.

Photoinduced Cation Coupled Electron Transfer for Efficient Ionic Power Harvesting Based on CNT/MoS Heterostructures.

Inspired from the light-driven proton-coupled electron transfer during photosynthesis in green plants, an engineered CNT/MoS biomimetic nanofluidic system has been successfully developed, which achieves photo-activated ion transport in iso-concentration electrolytes through synergistic photothermal-photoelectric coupling. Under light irradiation, localized photothermal effects in CNT generate a temperature gradient, driving thermophoretic ion migration, while the same irradiation triggers a MoS-mediated surface charge gradient via photoexcited carrier redistribution, encompassing both vertical charge transfer and horizontal carrier diffusion. The resultant dual gradients of surface charge asymmetry and temperature differential cooperatively drive autonomous ion pumping.

Expert consensus on cryosurgery therapy of mucosal melanoma on head and neck.

Cryoablation therapy for tumors has a long history of clinical application. Its anti-tumor mechanisms and histopathological changes have been well established, with extensive clinical practice demonstrating its safety and efficacy, theoretically making it an ideal modality for tumor treatment. Historically constrained by limitations in cryogenic media and freezing equipment, its therapeutic effectiveness and clinical adoption were significantly restricted.

The critical role of non-contrast chest CT in avoiding thrombolysis catastrophe: A case of acute aortic dissection masquerading as ischemic stroke.

Introduction And Importance: Aortic dissection (AD) complicating acute ischemic stroke poses significant therapeutic challenges, particularly regarding thrombolytic contraindications that may substantially increase mortality risk. This underscores the critical need for expedited differential diagnosis in such clinical scenarios.

Case Presentation: An 80-year-old male presented with acute-onset left-sided hemiplegia and unresponsiveness.

Association between estimated pulse wave velocity and mortality risk in patients with acute ischemic stroke.

Estimated pulse wave velocity (ePWV) has been proposed as a potential predictor of mortality in patients with acute ischemic stroke (AIS). This study aimed to evaluate the relationship between ePWV and all-cause mortality in AIS patients. Among 2,416 AIS patients initially screened, 2176 met the inclusion criteria and were included in the final analysis.

[Clinical analysis of changes in the position of the condyle and temporomandibular joint after repair of mandibular defects].

Objectives: This retrospective study aimed to investigate factors influencing positional changes of the condyle and temporomandibular joint (TMJ) following mandibular defect reconstruction with bone flaps, and to evaluate the biomechanical impacts of flap reconstruction on condylar positioning, thereby providing evidence for optimizing surgical protocols and TMJ functional rehabilitation.

Methods: A retrospective study was conducted on 90 patients undergoing mandibular segmental resection with immediate bone flap reconstruction at Guizhou Medical University Affiliated Stomatological Hospital (June 2019 to May 2024). After strict screening, 50 cases with complete data were analyzed.

Design of high-energy X-ray conversion target based on linear electron accelerator.

High-energy X-rays can be employed to inspect fuel elements, even weld seams, cracks, and internal structural deformations of the components due to their density-sensitive characteristics and strong penetration capabilities. The quality of these X-rays is determined by various factors such as the X-ray conversion target, the cooling system for the conversion target, and the filter type, thereby influencing the detection accuracy. This study was conducted using an electron linear accelerator with an energy of 10 MeV and an average current of 150 μA.

Network toxicological and molecular docking in investigating the mechanisms of toxicity of agricultural chemical pyraclostrobin.

The safety of agricultural products is significant to human health. Pyraclostrobin (PYR), a common methoxycarbonyl fungicide, is a crucial role in the prevention of fungal infections during the transport and storage of agricultural products, including vegetables and fruits. Using a multi-analytical approach, integrating toxicological database mining, protein-protein interaction (PPI) network analysis, and molecular docking, this study aimed to elucidate the molecular mechanisms underlying the toxicity of PYR.

Association between social determinants of health and periodontitis: a population-based study.

Background: The association between socioeconomic status and periodontitis is intricate. This research examines how social determinants of health relate to periodontitis in U.S.

A case report of mandibular aggressive fibromatosis in a pediatric patient: diagnostic challenges and surgical management.

Introduction: Aggressive fibromatosis (AF) of the mandible is a rare, locally invasive tumor with significant diagnostic and therapeutic challenges. The incidence of AF in the head and neck region is estimated at 2-4 cases per 10 million people annually, with mandibular involvement being even less common. Its infiltrative nature and high recurrence risk necessitate meticulous surgical planning and prolonged follow-up.

Mechanically Stable and Damage Resistant Freestanding Ultrathin Silver Nanowire Films with Closely Packed Crossed-Lamellar Structure.

One-dimensional (1D) functional nanowires are widely used as nanoscale building blocks for assembling advanced nanodevices due to their unique functionalities. However, previous research has mainly focused on nanowire functionality, while neglecting the structural stability and damage resistance of nanowire assemblies, which are critical for the long-term operation of nanodevices. Biomaterials achieve excellent mechanical stability and damage resistance through sophisticated structural design.

[Mechanism of kaempferol on intervertebral disc degeneration based on p38 MAPK signaling pathway].

This study investigated the mechanism by which kaempferol(KAE) affected intervertebral disc degeneration(IDD) through the p38 mitogen-activated protein kinase(p38 MAPK) signaling pathway. Rats were randomly divided into five groups: control group, model group, low-dose KAE group, medium-dose KAE group, and high-dose KAE group. An IDD model was established by needle puncture of the caudal intervertebral discs.

Smoking status and edentulism among older Chinese: a cohort study.

Background: The harmful impact of tobacco smoke on health is widely recognized, linking it to various diseases. However, the link between tobacco smoke and edentulism in China's population hasn't been fully investigated. This study aims to fill this gap by exploring smoking habits and the possible connection between tobacco smoke and edentulism in a nationally representative Chinese cohort.

Caveolin-1 modulates cisplatin sensitivity in oral squamous cell carcinoma through ferroptosis.

Objective: Cisplatin-based chemotherapy is widely used for the treatment of oral squamous cell carcinoma (OSCC), but drug resistance and decreased sensitivity often occur during the treatment, greatly weakening its therapeutic effect. Caveolin-1 (CAV1), a protein related to ferroptosis, is involved in regulating the resistance and sensitivity of various tumor chemotherapies. This study aims to investigate whether CAV1 can regulate the sensitivity of OSCC to cisplatin through ferroptosis.

Characteristics of the immune environment in prostate cancer as an adjunct to immunotherapy.

Background And Aims: The tumor microenvironment (TME) exerts an important role in carcinogenesis and progression. Several investigations have suggested that immune cell infiltration (ICI) is of high prognostic importance for tumor progression and patient survival in many tumors, particularly prostate cancer. The pattern of immune infiltration of PCa, on the other hand, has not been thoroughly understood.

A novel approach for credit card fraud transaction detection using deep reinforcement learning scheme.

Online transactions are still the backbone of the financial industry worldwide today. Millions of consumers use credit cards for their daily transactions, which has led to an exponential rise in credit card fraud. Over time, many variations and schemes of fraudulent transactions have been reported.

Investigating the causal relationship between human blood/urine metabolites and periodontal disease using two-sample Mendelian randomization.

Background And Aims: The aim is to investigate the cause-and-effect connection between metabolites found in blood/urine and the likelihood of developing periodontal disease (PD) through the utilization of a two-sample Mendelian randomization (MR) method.

Methods: Using an inverse variance weighted (IVW) method and two additional two-sample MR models, we examined the relationship between blood/urine metabolites and PD by analyzing data from a comprehensive metabolome-based genome-wide association study and the Genome-Wide Association Studies (GWAS) of PD. To assess the consistency and dependability of the findings, diversity, cross-effects, and sensitivity analyses were conducted.

Frequency tripled semiconductor disk laser with over 0.5 W ultraviolet output power.

Semiconductor disk lasers can produce high output power and good beam quality simultaneously. The high intracavity circulating power of about hundreds of watts, along with the flexibility of tailorable emitting wavelengths, make it an attractive light source for obtaining ultraviolet (UV) radiation from near-infrared lasers through nonlinear frequency conversion. This work reports a frequency tripled 327 nm semiconductor disk laser with record output power and wavelength tuning range by using a type-I phase-matched LiBO (LBO) crystal and a type-I phase-matched β-BaBO (BBO) crystal as the frequency-doubling and -tripling crystals respectively.

[Clinical study of modified suspension reduction method combined with percutaneous vertebroplasty in the treatment of thoracolumbar osteoporotic compression fracture].

Objective: To investigate the clinical effect of modified suspension reduction method combined with percutaneous vertebroplasty in the treatment of osteoporotic thoracolumbar compression fractures.

Methods: From February 2020 to October 2021, 92 patients with thoracolumbar osteoporotic compression fracture were treated by percutaneous vertebroplasty. According to different treatment methods, they were divided into the observation group and the control group.