Efficient Urea Oxidation on MnCO/Ni(OH) Nanoflower Arrays Via Interfacial Coupling.

The electrochemical urea oxidation reaction (UOR) presents an energy-efficient alternative to the sluggish oxygen evolution reaction (OER), operating at a substantially lower thermodynamic potential and thereby reducing the energy input for hydrogen production by approximately 70%. Simultaneously, UOR facilitates wastewater remediation, offering dual environmental and energy benefits. In this work, we report a MnCO/Ni(OH) heterostructured nanoflower array directly grown on conductive carbon cloth that exhibits outstanding UOR catalytic activity and stability.

Comparison of 68Ga-FAPI-04 and 18F-FDG in Primary Splenic Angiosarcoma.

Primary splenic angiosarcoma is a rare, aggressive tumor, characterized by rapid metastasis and poor prognosis. Herein, we report a case of 18F-FDG and 68Ga-FAPI-04 PET/CT imaging in a 57-year-old man with primary splenic angiosarcoma. 68Ga-FAPI-04 PET/CT presented much higher uptake in the lesions compared with 18F-FDG PET/CT, showing better diagnostic performance.

Evaluation of Modified CC Stabilization using LARS Artificial Ligament in Unstable Distal Clavicle Fracture.

Unstable distal clavicle fractures are clinically common, and there is no consensus regarding gold-standard treatment. The purpose of this study was to report on a new surgical technique for the treatment of unstable distal clavicle fracture with modified coracoclavicular (CC) stabilization using a ligament augmentation and reconstruction system (LARS) of an artificial ligament, and to compare the clinical and radiographic outcomes with hook-plate fixation.Thirty patients with unstable distal clavicle fractures were treated with modified coracoclavicular (CC) stabilization using either a ligament augmentation and reconstruction system (LARS) or open reduction internal fixation with a hook plate.

Anterior lumbar‒iliac fixation for unstable pelvic fractures: a novel surgical technique.

The treatment of unstable pelvic fractures is a great challenge for surgeons. Traditional steel plate fixation and sacroiliac screw fixation are not sufficient to provide longitudinal support. At present, surgical lumbar‒iliac fixation is a reliable fixation technique.

A Large-Scale Multispecialty Evaluation of Web-Based Simulation in Medical Microbiology Laboratory Education: Randomized Controlled Trial.

Background: Traditional laboratory teaching of pathogenic cocci faces challenges in biosafety and standardization across medical specialties. While virtual simulation shows promise, evidence from large-scale, multidisciplinary studies remains limited.

Objective: The study aims to evaluate the effectiveness of integrating virtual simulation with traditional laboratory practice in enhancing medical microbiology education, focusing on the identification of biosafety level 2 pathogenic cocci.

Hepatic ischemia-reperfusion and mitochondrial quality control: potential therapeutic targets.

Background: Hepatic ischemia-reperfusion injury (HIRI) represents a significant challenge in liver surgical procedures. This complex pathology arises from the interplay of inflammation, oxidative damage, and regulated cell death cascades. Compromised mitochondrial function critically contributes to HIRI progression.

ARRDC3 promotes lysosome-mediated YAP degradation to inhibit enterovirus replication.

Enterovirus D68 (EV-D68) and enterovirus A71 (EV-A71) are two major types of enteroviruses that pose emerging challenges to public health and have the potential to cause outbreaks, yet their pathogenic mechanisms remain largely unexplored. Arrestin domain containing 3 (ARRDC3) is a vital regulator of glucose metabolism, cancer development, and inflammation. Whether ARRDC3 contributes to innate antiviral immunity is undefined.

Pregnane X Receptor Activation Induces Ferroptosis Resistance Through Upregulation of FSP1.

Ferroptosis, an iron-dependent form of programmed cell death, is emerging as a novel approach to tackling cancer. Cancer cells require large amounts of iron for their rapid growth, making them intrinsically vulnerable to ferroptosis. However, cancer cells have developed several important antioxidant pathways to counteract ferroptosis.

68Ga-Trivehexin PET/CT Enhances Detection of Small Primary Lesions Than 18F-FDG PET/CT in Breast Cancer.

We compared 68Ga-Trivehexin PET/CT imaging with 18F-FDG in a 49-year-old woman diagnosed with breast cancer. While both imaging modalities detected a soft tissue mass in the central left breast, 68Ga-Trivehexin PET/CT identified not only the large lesion but also 3 additional tiny foci that were undetected by 18F-FDG PET/CT. Our report suggested that 68Ga-Trivehexin PET/CT might offer superior detection efficacy for breast cancer compared with 18F-FDG PET/CT, highlighting its potential as an alternative imaging agent.

Hypoxia-Driven Regulation of Osteogenic Differentiation in Human Periosteal Stem Cells via the HIF-1α/miR-129-5p/BMP2 Axis.

This study aims to elucidate the regulatory mechanisms of osteogenic differentiation in human periosteal stem cells (hPSCs) under hypoxia, focusing on the HIF-1α/miR-129-5p/BMP2 axis. RNA-seq identified miRNAs involved in hypoxia-induced differentiation, and key molecules were validated at molecular and cellular levels. Hypoxia significantly enhanced osteogenic differentiation, as demonstrated by increased mineralization and upregulated osteogenic markers (BMP2, RUNX2, and Osterix).

Research Progress on Electrode Structure of Transparent Supercapacitor.

Supercapacitors are a crucial part of electronic equipment, the development of smart devices such as LEDs, touchscreens, and portable electronics, prompt supercapacitors with new features such as transparency and flexibility. The construction of transparent electrodes includes two main ways: i) electrode material is intrinsically transparent, and ii) networks with controllable distribution of voids or discontinuous regions (multi-gap network structures) increase the transmittance to achieve transparency. Few types of transparent materials, high costs, and complicated preparation limit the development of transparent supercapacitor (TSCs).

CbuERF114, an ethylene responsive factor, regulates floral transition in Catalpa bungei.

Understanding the flowering of woody plants is crucial for controlling flowering time and shortening breeding cycles, yet the mechanisms are largely unknown. APETALA2/ethylene response factor (AP2/ERF) transcription factors are essential in floral transition and development. We report an early-flowering (EF) variety of Catalpa bungei that blooms in its planting year, whereas normal-flowering (NF) requires 5-7 years.

Glymphatic dysfunction is related to motor disability fully mediated by gray matter degeneration in early-stage Parkinson's disease.

Background: Glymphatic dysfunction plays a critical role in Parkinson's disease (PD), but its impact on neurodegeneration and clinical symptoms in the early-stage remains unclear. This study investigates the relationship between glymphatic dysfunction, gray matter (GM) degeneration, and clinical deterioration in early-stage PD.

Methods: A total of 249 early-stage PD patients and 114 healthy controls (HC) underwent T1-weighted and DTI scans, along with clinical assessments.

Future research focus and trends in nerve transplantation: a bibliometrics research from 2015 to 2024.

Background: Nerve transplantation, as a classical nerve repair technique, has received extensive attention in recent years. However, the rapid development of this field has also brought challenges such as knowledge fragmentation and the blurring of research hotspots. Therefore, at present, the future research direction of this field is not clear.

Dual-Defect Nitrogen-Rich Carbon Nitride-Based Heterostructural Nanocatalyst for Improving the Therapeutic Efficacy of αPD-1 via Tumor Immune Microenvironment Remodelling.

Low immunogenicity, insufficient immune infiltrates, and inhibitive microenvironment of tumors ruthlessly weakened the therapeutic efficacy of immunotherapies. How to improve the therapy efficacy by reshaping the tumor immune microenvironment still remains a challenge that needs to be urgently addressed. Here, a novel dual-defect nitrogen-rich carbon nitride-based heterostructural nanocatalyst (CNO@CuMS) possessing brilliant piezocatalytic HO generation, sonocatalytic O generation, Fenton-like catalytic •OH generation, and cell cuproptosis inducing properties are developed.

Overexpression of a BAHD acyltransferase-like gene OsDCR produces longer grains by modulating BR and GA contents in rice.

Although a lot of studies have shown the regulatory effects of individual hormones on rice grain size, the effects of cross-talk between gibberellins and brassinosteroids on grain size remain to be investigated. The OsDCR gene, encoding a BAHD acyltransferase-like protein, positively controls rice grain length. Specifically, over-expression of OsDCR results in enlarged grain length by increasing the longitudinal cell length of spikelet hulls.

Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study.

Background: While the phenotypic link between body mass index (BMI) and some female reproductive disorders is well established, the genetic architecture and causal relationships have not been systematically studied. We aimed to create an atlas of the shared genetic associations of BMI and 16 female reproductive disorders and to identify their common risk loci, biological pathways, and potential mechanisms.

Methods: We assessed the genetic correlations between BMI and 16 reproductive disorders using summary data from large-scale genome-wide association studies.

Structural and functional analysis of a homotrimeric collagen peptide.

Objective: This study aimed to chemically synthesize a homotrimeric collagen peptide, evaluate its safety, and assess its effectiveness in promoting collagen synthesis.

Methods: A homotrimeric collagen peptide was synthesized and structurally characterized using circular dichroism and infrared spectroscopy. Thermal stability was analyzed by TG-DSC, and molecular weight and amino acid composition were determined.

Simultaneous Analysis of Nine Aromatic Amines in Mainstream Cigarette Smoke Using Modified QuEChERS and Liquid Chromatography-Tandem Mass Spectrometry.

A modified QuEChERS method coupled with high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed to detect nine aromatic amines in mainstream cigarette smoke simultaneously. In this study, a Cambridge filter pad, impregnated with a hydrochloric acid-ethanol solution, was used to trap aromatic amines in vapor and particulate phases in mainstream cigarette smoke. The collection efficiency of aromatic amines for this method was significantly improved compared with conventional methods of trapping aromatic amines using a combination of Cambridge filter pad followed by impinger traps containing dilute acid solution.

Community built environment attributes moderate the relationship between family support and depression among older adults in urban China.

Background: This study examined the moderating effects of built environment attributes on the relationship between family support and depressive symptoms among community-dwelling older adults in urban China.

Methods: Quota sampling was used to recruit participants from Tianjin (one of the four municipalities in China) and Shijiazhuang (the capital city of Hebei Province). Face-to-face interviews were conducted with 799 respondents aged 60 years and older, in either their homes or local community centers.

Circ847 upregulation via CAFs suppresses salivary adenoid cystic carcinoma progression through VIM-EMT.

Salivary adenoid cystic carcinoma (SACC) is prone to metastasis, which strongly affects its prognosis. Cancer-associated fibroblasts (CAFs) play important roles in SACC metastasis. The purpose of this study was to identify and explore the key regulatory mechanisms of the altered expression of circRNAs in SACC CAFs.

Genome-Wide Identification and Expression Profiling of Dehydration-Responsive Element-Binding Family Genes in Flax ( L.).

Dehydration-responsive element-binding () transcription factors are ubiquitous in plants and regulate plant growth, development, signal transduction, and responses to stress, particularly drought stress. However, genes in flax have not previously been studied. This study conducted a comprehensive and systematic analysis of the gene family in flax ( L.

Gel@CAT-L hydrogel mediates mitochondrial unfolded protein response to regulate reactive oxygen species and mitochondrial homeostasis in osteoarthritis.

Objective: This study investigates the role of Gelatin-Catalase (Gel@CAT)-L hydrogel in mediating reactive oxygen species (ROS) production and maintaining mitochondrial homeostasis through SIRT3-mediated unfolded protein response (UPR), while exploring its involvement in the molecular mechanism of osteoarthritis (OA).

Methods: Self-assembled Gel@CAT-L hydrogels were fabricated and characterized using transmission electron microscopy, mechanical testing, external release property evaluation, and oxygen production measurement. Biocompatibility was assessed via live/dead cell staining and CCK8 assays.

Neoadjuvant Chemotherapy With Cisplatin Up-Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14-Mediated EMT Activation.

Neoadjuvant chemotherapy has been widely used for the treatment of solid tumors. However, clinical observations have shown that patients with oral squamous cell carcinoma (OSCC) who are receiving neoadjuvant chemotherapy with cisplatin still face issues such as a poor lymph node response and even lymph node progression, but the underlying mechanisms remain unidentified. In this work, it is found that low-dose cisplatin promoted oral squamous cell carcinoma migration, invasion and lymph node metastasis, and gasdermin D (GSDMD) is identified as a potential regulator.

Chemokine CXCL14 Inhibits the Survival of inside Macrophages by Upregulating A20 to Promote ROS Production.

Tuberculosis remains a major global health threat, with traditional antibiotic treatments facing challenges such as drug resistance. Host-directed therapy (HDT) has emerged as a promising approach to combat tuberculosis by enhancing the host immune response. CXCL14, a chemokine family member, plays a crucial role in regulating host antipathogenic immune responses.