Redefining Risk, Biomarkers, and Precision Therapy for Hereditary Ovarian Cancer: A Review.

The early 1990s marked a pivotal era in oncology with the elucidation of the molecular etiology of hereditary cancers, fundamentally transforming our understanding of genetic susceptibility. Ovarian cancer (OC) remains the most fatal gynecologic malignancy, often diagnosed at advanced stages with limited modifiable risk factors. Globally, it ranks as the eighth most frequently diagnosed cancer in women, underscoring its significant public health burden.

Effect of Blue Covarine Toothpastes on Tooth Colour: A Randomised Crossover Study.

Objective: To measure the effect of toothpastes containing blue covarine on tooth whiteness and yellowness.

Methods: This was a randomised, double-blind, 4-period, crossover design study conducted at a Chinese clinical research facility. Sixty-six participants with 2 natural upper central incisors (UCIs) with Vita tooth shade in range 2M2 to 3M3, without visible damage, gum recession, restorations or extrinsic/intrinsic stain, were allocated to evaluate 4 test toothpastes in random order using Williams square approach.

The January 2022 Hunga eruption cooled the southern hemisphere in 2022 and 2023.

The 2022 Hunga volcanic eruption injected a significant quantity of water vapor into the stratosphere while releasing only limited sulfur dioxide. It has been proposed that this excess water vapor could have contributed to global warming, potentially pushing temperatures beyond the 1.5 °C threshold of the Paris Climate Accord.

A multi-method approach to assess long-term urbanization impacts on an ecologically sensitive urban wetland in Northeast India.

Deepor Beel, a natural wetland fringing the outskirts of the sub-Himalayan city of Guwahati in North-East India, has been under threat of urbanization since the past few decades. With a shrinking perimeter, the wetland - a favorite winter halt of migrating Siberian birds, manages to survive between anthropogenic aggression and ecological existence. This study maps the wetland's aerial shrinkage and environmental health from the 1990s to the 2020s using satellite imagery at five-year intervals.

Comparison of efficacy and toxicity of chemotherapeutic regimens used as adjuvant and/or neoadjuvant chemotherapy in penile cancer patients.

Objective: To compare the efficacy and toxicity of different chemotherapeutic regimens used as adjuvant or neoadjuvant chemotherapy in penile cancer patients.

Methodology: This observational study was carried out at Mahavir Cancer Sansthan & Research Centre (MCSRC), Patna, involving 112 patients who received various chemotherapy regimens: 5-Fluorouracil with Cisplatin (FP), Paclitaxel with Carboplatin (TP), Paclitaxel with Cisplatin (TP), and Paclitaxel with Ifosfamide and Cisplatin (TIP). Efficacy was assessed based on tumor response after Neoadjuvant Chemotherapy (NACT) using RECIST v1.

Fabrication of 2D/2D BiMoO/S@g-CN type-II heterojunction photocatalyst for enhanced visible-light-mediated degradation of tetracycline in wastewater.

Aquatic biota and human health are seriously threatened by the dramatic rise in antibiotics in environmental matrices. In this regard, the present study aims to improve knowledge of the combined effects of heterojunction design and defect engineering on the photocatalytic degradation of pharmaceuticals in aqueous matrices. Advantageously, the positioning of the valence band (VB) and conduction band (CB) levels of S@g-CN, being higher than those of BiMoO, demonstrates the feasibility of forming a type-II heterojunction between these materials.

A semantic segmentation framework with UNet-pyramid for landslide prediction using remote sensing data.

Landslides are frequent all over the world, posing serious threats to human life, infrastructure, and economic operations, making them chronic disasters. This study proposes a novel landslide detection methodology that is automated and based on a hybrid deep learning approach. Currently, Deep Learning is constrained by the lack of applicability, lack of data, and low efficiency in landslide detection but with recent advancement in deep learning-based solutions for landslide detection has sparked considerable advantages over traditional techniques.

Rare case of hyaline fibromatosis syndrome.

Hyaline fibromatosis syndrome is a rare, progressive and fatal autosomal recessive disorder characterised by multiple subcutaneous skin nodules, osteopenia, joint contractures, failure to thrive, diarrhoea and frequent infections. There is diffuse deposition of hyaline material in the skin, gastrointestinal tract, muscle and endocrine glands. The disease is often underdiagnosed since infants affected with the disease pass away early prior to establishing a final diagnosis.

A comprehensive review on the treatment of pesticide-contaminated wastewater with special emphasis on organophosphate pesticides using constructed wetlands.

Pesticides pose a significant threat to aquatic ecosystems due to their persistent nature and adverse effects on biota. The increased detection of pesticides in various water bodies has prompted research into their toxicological impacts and potential remediation strategies. However, addressing this issue requires the establishment of robust regulatory frameworks to determine safe thresholds for pesticide concentrations in water and the development of effective treatment methods.

Simultaneous ammonia and organics degradation from municipal landfill leachate by electrochemical oxidation.

The two primary issues for wide implementation of the electrochemical oxidation of wastewater are the significant cost of electrode and high energy consumption. On the other side, conventional biological processes and membrane technology have several drawbacks for recalcitrant landfill leachate (LL) treatment. To address these issues, graphite/PbO anode was used to treat medium to mature age (biodegradability index, 5-day biochemical oxygen demand/chemical oxygen demand: 0.

Oxidative treatment of micropollutants present in wastewater: A special emphasis on transformation products, their toxicity, detection, and field-scale investigations.

Micropollutants have become ubiquitous in aqueous environments due to the increased use of pharmaceuticals, personal care products, pesticides, and other compounds. In this review, the removal of micropollutants from aqueous matrices using various advanced oxidation processes (AOPs), such as photocatalysis, electrocatalysis, sulfate radical-based AOPs, ozonation, and Fenton-based processes has been comprehensively discussed. Most of the compounds were successfully degraded with an efficiency of more than 90%, resulting in the formation of transformation products (TPs).

Insights into the performance of binary heterojunction photocatalysts for degradation of refractory pollutants.

The uncontrolled discharge of industry- and consumer-derived micropollutants and synthetic contaminants into freshwater bodies represents a severe threat to human health and aquatic ecosystem. Inexpensive and highly efficient wastewater treatment methods are, therefore, urgently required to eliminate such non-biodegradable, recalcitrant, and toxic organic pollutants. In this context, advanced oxidation processes, particularly heterogenous photocatalysis, have received enormous attention over the past few decades.

The Impacts and Changes Related to the Cancer Drug Resistance Mechanism.

Background: Cancer drug resistance remains a difficult barrier to effective treatment, necessitating a thorough understanding of its multi-layered mechanism.

Objective: This study aims to comprehensively explore the diverse mechanisms of cancer drug resistance, assess the evolution of resistance detection methods, and identify strategies for overcoming this challenge. The evolution of resistance detection methods and identification strategies for overcoming the challenge.

Visible Light-Assisted Degradation of Sulfamethoxazole on 2D/0D Sulfur-Doped BiO/MnO Z-Scheme Heterojunction Immobilized Photocatalysts.

Retrieving the spent photocatalysts from the reaction system is always a challenging task. Therefore, the present work is focused on immobilizing sulfur-doped-BiO/MnO (S-BOMO) heterojunction photocatalysts over different support matrices and evaluating their performance for the removal of sulfamethoxazole (SMX) in water under visible light. Our findings revealed S-BOMO coated clay beads (S-BOMO CCB) achieving more than 86% (240 min) SMX degradation ∼3, ∼1.

Combination of advanced biological systems and photocatalysis for the treatment of real hospital wastewater spiked with carbamazepine: A pilot-scale study.

Over the past few decades, the increase in dependency on healthcare facilities has led to the generation of large quantities of hospital wastewater (HWW) rich in chemical oxygen demand (COD), total suspended solids (TSS), ammonia, recalcitrant pharmaceutically active compounds (PhACs), and other disease-causing microorganisms. Conventional treatment methods often cannot effectively remove the PhACs present in wastewater. Hence, hybrid processes comprising of biological treatment and advanced oxidation processes have been used recently to treat complex wastewater.

Life cycle assessment of municipal solid waste generated from hilly cities in India - A case study.

Improper disposal of waste poses a grave environmental threat, contributing to pollution of air, water, and soil. It is necessary to address this issue in order to mitigate the adverse effects of solid waste on both the environment and public health. In many developing nations, municipal authorities of bigger cities are enduring significant challenges in proper management of waste.

Sulfamethoxazole removal from wastewater via anoxic/oxic moving bed biofilm reactor: Degradation pathways and toxicity assessment.

The effects of sulfamethoxazole (SMZ), an antibiotic commonly detected in the water environment, on the performance of a single staged anoxic/oxic moving bed biofilm reactor (A/O MBBR), was investigated. The anoxic zone played a key role in the removal of SMZ with a percentage of contribution accounting for around 85% in the overall removal. Denitrifying heterotrophic microbes present in the anoxic zone showed relatively more resistance to higher SMZ loads.

Synergistic mechanisms for the superior sorptive removal of aquatic pollutants via functionalized biochar-clay composite.

This study investigated the successful synthesis of functionalized algal biochar-clay composite (FBKC). Subsequently, the sorption performance of FBKC towards norfloxacin (NFX) antibiotic and crystal violet dye (CVD) from water was extensively assessed in both batch and continuous flow systems. A series of characterization techniques were carried out for FBKC and the utilized precursors, indicating that the surface area of FBKC was increased thirty-fold with a well-developed pore structure compared to the original precursors.

Development of microbial fuel cell integrated constructed wetland (CMFC) for removal of paracetamol and diclofenac in hospital wastewater.

Hospital wastewater management has become a significant concern across the globe due to the presence of pharmaceutically active compounds (PhACs) and other toxic substances, which can potentially disrupt ecosystems. The presence of recalcitrant PhACs in hospital wastewater increases the difficulty level for conventional wastewater treatment systems. Furthermore, incorporating advanced oxidation-based treatment systems increase capital and operation costs.

A critical assessment of SARS-CoV-2 in aqueous environment: Existence, detection, survival, wastewater-based surveillance, inactivation methods, and effective management of COVID-19.

In early January 2020, the causal agent of unspecified pneumonia cases detected in China and elsewhere was identified as a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and was the major cause of the COVID-19 outbreak. Later, the World Health Organization (WHO) proclaimed the COVID-19 pandemic a worldwide public health emergency on January 30, 2020. Since then, many studies have been published on this topic.

Elucidating the performance of integrated anoxic/oxic moving bed biofilm reactor: Assessment of organics and nutrients removal and optimization using feed forward back propagation neural network.

A lab-scale integrated anoxic and oxic (A/O) moving bed biofilm reactor (MBBR) was investigated for the removal of organics and nutrients by varying chemical oxygen demand (COD) to NH-N ratio (C/N ratio: 3.5, 6.75, and 10), hydraulic retention time (HRT: 6 h, 15 h, and 24 h), and recirculation ratio (R: 1, 2, and 3).

Idiopathic Intracranial Hypertension and Endoscopic Optic Nerve Sheath Fenestration.

Idiopathic intracranial hypertension (IIH), also called as benign intracranial hypertension is a disorder, which is  considered benign in its course except its' ill effects on vision. Ocular findings in IIH such as papilledema, macular changes, retinal micro haemorrhages, cotton wool spots and tortuosity of vessels are the prominent features in funduscopy examination in these patients. Papilledema is a hallmark feature for evaluation of response to treatment.

Application of a new baffled horizontal flow constructed wetland-filter unit (BHFCW-FU) for treatment and reuse of petrochemical industry wastewater.

The shortage of water resources and generation of large quantum of wastewater has posed a significant concern to the environment and public health. Recent research on wastewater treatment has started to focus on reusing wastewater for different activities to reduce the stress on natural water resources. Constructed wetland (CWs) is a low-cost wastewater treatment option.