Effect of Blue Covarine Toothpastes on Tooth Colour: A Randomised Crossover Study.

Objective: To measure the effect of toothpastes containing blue covarine on tooth whiteness and yellowness.

Methods: This was a randomised, double-blind, 4-period, crossover design study conducted at a Chinese clinical research facility. Sixty-six participants with 2 natural upper central incisors (UCIs) with Vita tooth shade in range 2M2 to 3M3, without visible damage, gum recession, restorations or extrinsic/intrinsic stain, were allocated to evaluate 4 test toothpastes in random order using Williams square approach.

Endometrial metastasis of lung adenocarcinoma: a case report.

The female genital tract is an infrequent site of metastasis, in particular from extragenital primary tumors such as non-small cell lung cancer. Ovarian metastases have been described as disseminations of lung adenocarcinoma; rare cases of secondary localizations in adnexa, cervix and vagina were also observed in the literature, but none of these had endometrial involvement. We report the first case, to our knowledge, of non-small cell lung cancer with metastatic spread to the endometrium.

Typhlitis during second-line chemotherapy with pemetrexed in non-small cell lung cancer (NSCLC): A case report.

Neutropenic enterocolitis, or typhlitis, is an unusual acute complication of chemotherapy-induced neutropenia, characterized by inflammatory process involving colon and/or small bowel that may progress to necrosis, haemorrhage, perforation and septicaemia. Typhlitis is usually seen in the setting of severe chemotherapy-induced neutropenia for acute leukaemia. Nevertheless, it is increasingly recognized as a complication of therapy in solid tumors.