An intelligent diagnosis method for cardiovascular diseases based on the CNN-CBAM-GRU model.

Early diagnosis of cardiovascular diseases (CVDs) is essential for improving patient outcomes. As a primary diagnostic modality, electrocardiogram (ECG) signals pose challenges for automatic classification due to their complex temporal and morphological characteristics. This study proposes a CNN-CBAM-GRU model that integrates Convolutional Neural Networks (CNN), the Convolutional Block Attention Module (CBAM), and Gated Recurrent Units (GRU) to enhance both spatial feature representation and temporal sequence modeling.

Comparative risk of high-risk neoplasia after polypectomy among individuals aged below 50 years versus 50 years and older.

Background: Limited evidence supports colonoscopy surveillance practices among individuals aged <50 years.

Objective: To compare the risk of polyp recurrence and colorectal cancer (CRC) among young and old adults after polypectomy.

Design: We prospectively examined the risk of metachronous high-risk neoplasia, including high-risk adenoma, high-risk serrated polyp (SP) and CRC, according to index colonoscopy findings among individuals aged <50 years and ≥50 years who had received ≥1 follow-up colonoscopy in the Mass General Brigham Colonoscopy Cohort (2007-2023).

Development of three-dimensional forward modeling and observation device for leakage electric field in the process of foundation pit pumping test.

Early detection of leakage in foundation pit retaining structures during excavation is critical for ensuring both construction safety and the integrity of adjacent buildings. Conventional surface direct current methods suffer from poor resolution, low interference to resistance, and limited capability in pinpointing leakage locations. To achieve accurate leakage identification and enhance the quality control of major engineering projects, this study first establishes a coupled electrokinetic-steady electric field response mechanism by integrating the naturally occurring electric field from electrokinetic effects in leakage zones with artificial steady electric fields during pumping tests.

Innovation networks in the advanced medical equipment industry: supporting regional digital health systems from a local-national perspective.

This study investigates the spatial structure and influencing factors of the innovation network in the advanced medical equipment and device manufacturing industry in the Yangtze River Delta (YRD). This industry is crucial to public health system resilience and regional industrial upgrading. Drawing on joint patent data from the IncoPat Global Patent Database covering the period 2005-2024, the study constructs innovation networks and conducts comparative analyses from both national and regional perspectives using social network analysis and geodetector methods.

X-UNet:A novel global context-aware collaborative fusion U-shaped network with progressive feature fusion of codec for medical image segmentation.

Due to the inductive bias of convolutions, CNNs perform hierarchical feature extraction efficiently in the field of medical image segmentation. However, the local correlation assumption of inductive bias limits the ability of convolutions to focus on global information, which has led to the performance of Transformer-based methods surpassing that of CNNs in some segmentation tasks in recent years. Although combining with Transformers can solve this problem, it also introduces computational complexity and considerable parameters.

A Wood-Derived Janus Aerogel with Excellent Salt Resistance for Highly Efficient Interfacial Solar Evaporation and Wastewater Purification.

Interfacial solar-driven steam generation, which is recognized as an emerging fresh water acquisition technique, has attracted widespread scientific attention recently. Developing stable and sustainable solar evaporators featuring desirable evaporation performance, wonderful salt rejection, and superior wastewater purification remains a sizable challenge. Herein, a Janus aerogel derived from natural balsa wood was successfully fabricated through facile procedures such as chemical removal, freeze-drying, and subsequent deposition.

Branched Molecule Carrying Multiple Amide Groups for Accelerating Zinc Anode, Testified by In Situ Monitoring and Improved Batteries.

Rechargeable aqueous zinc-ion batteries (ZIBs) have been recognized as a promising next generation of second-level energy storage systems, with fine characteristics of pronounced low cost and safety. However, zinc dendrite growth, zinc corrosion, and side reactions on the Zn anode surface in aqueous electrolyte cause severe challenges for the practical application of aqueous ZIBs. Inspired by protein facial film, this study proposed to employ low concentrations (10 mol/L magnitude, 5.

Dynamic Modeling of the Sulfur Cycle in Urban Sewage Pipelines Under High-Temperature and High-Salinity Conditions.

This study addresses the microbial corrosion of cement-based materials in coastal urban sewer networks, systematically investigating the kinetic mechanisms of sulfur biogeochemical cycling under seawater infiltration conditions. Through dynamic monitoring of sulfide concentrations and environmental parameter variations in anaerobic pipelines, a multiphase coupled kinetic model integrating liquid-phase, gas-phase, and biofilm metabolic processes was developed. The results demonstrate that moderate salinity enhances the activity of sulfate-reducing bacteria (SRB) and accelerates sulfate reduction rates, whereas excessive sulfide accumulation inhibits SRB activity.

Genome-wide association studies reveal genetic diversity and regulatory loci underlying dwarfing traits in banana.

Bananas (Musa ssp.) are globally important staple crops increasingly constrained by biotic stressors, climatic instability, and the high labor demands of cultivation. The genetic improvement of dwarf phenotypes offers a strategic pathway to enhance mechanization and reduce production costs.

Stress Resilience and Risk of Psychiatric Disorders After Childhood Bereavement.

Importance: Childhood bereavement increases the risk of common psychiatric disorders later in life. However, the role of stress resilience in this association remains underexplored.

Objective: To assess whether stress resilience mediates the association between childhood bereavement and psychiatric disorder risk in adulthood.

From Paroxysmal to Persistent Atrial Fibrillation: Progressive Fibrosis of the Left Atrial Posterior Wall.

Background: The path from paroxysmal to persistent atrial fibrillation (AF) is still poorly understood, leading to suboptimal treatment outcomes.

Objectives: In this study, the authors sought to investigate the level of fibrosis in different stages of AF with the use of F-labeled aluminum fluoride (AlF) targeting fibroblast activation protein inhibitor (FAPI) positron emission tomography (PET)-magnetic resonance imaging (MRI).

Methods: A total of 78 patients with AF and 49 health volunteers were enrolled in this study.

Online risk scores for pre- and postoperative prediction of early recurrence in hepatocellular carcinoma patients undergoing conversion liver resection after tyrosine kinase inhibitors and immune checkpoint inhibitors therapy.

Background: Conversion therapy with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) offers the potential for curative resection in unresectable hepatocellular carcinoma (HCC). However, early recurrence (≤2 years) after conversion liver resection remains a major concern. This study aimed to develop and validate online preoperative and postoperative risk scores to predict early recurrence in patients undergoing conversion liver resection.

Qi Yin San Liang San Decoction Relieves Gefitinib-Induced Diarrhea via the Modulation of Chemokines and Innate Immune Responses.

Background: Gefitinib is associated with various adverse reactions, with diarrhea being prevalent. It is mainly managed through lifestyle changes and symptomatic pharmacological interventions, but these approaches have limited effectiveness and frequent recurrence. Qi Yin San Liang San Decoction (QYSLS) shows promise in relieving gefitinib-induced diarrhea, but its mechanisms are unclear.

Single image sub-pixel rendering using a residual network for flat panel display.

The increase in pixel density exacerbates the process difficulty and manufacturing cost of flat panel displays, especially for Micro-LED displays. To alleviate this problem, this paper proposes a novel single-image subpixel rendering method using a residual network for RGBG square-arranged flat panel subpixel displays. The proposed method uses a residual network to achieve nonlinear mapping from the original image to the rendered image and designs a perceptual error loss function based on the contrast sensitivity function (CSF) of the human eye to find an optimal balance between luminance resolution and chromatic aliasing.

Investigation of cognitive enhancements and mechanisms of kinsenoside in APP/PS1 mice through network pharmacology, in vivo experiments, and machine learning.

Aims: To investigate the therapeutic effects of kinsenoside on cognitive dysfunction in APP/PS1 transgenic mice and to explore its potential targets.

Materials And Methods: Network pharmacology was employed to identify targets of kinsenoside in Alzheimer's disease (AD). The Morris water maze test was conducted to assess the therapeutic effects of kinsenoside on cognitive dysfunction in APP/PS1 transgenic mice, and immunofluorescence was used to evaluate the impact of kinsenoside on amyloid-beta (Aβ) pathology and brain lymphatic structure and function.

Regulating the Electric Double Layer Structures Driven by Current Density for High-Rate Aqueous Zinc Metal Batteries.

The notorious dendrite growth, serious Zn corrosion and hydrogen evolution confronted by the Zn anode greatly limit the cycle life of aqueous zinc metal batteries. Here, the structure of electrical double layer (EDL) is designed by a specifically adsorbed anionic surfactant (MOA) featuring a zincophilic phosphate group and hydrophobic long alkyl chain, decreasing the activity of water on the Zn anode, effectively inhibiting the side reactions. More importantly, the reconstructed EDL by MOA exhibits a high current response characteristic, leading to the formation of a denser and thinner EDL under a high current density, which accelerates the diffusion kinetics of Zn and benefits the uniform Zn plating/stripping.

Traditional Serrated Adenomas Associated With Risk of Subsequent High-Risk Polyps and Colorectal Cancer.

Introduction: Traditional serrated adenoma (TSA) is a rare yet established precursor to colorectal cancer (CRC). The risk of colorectal neoplasia after TSA removal remains unclear.

Methods: We identified participants without polyps or with TSAs during index colonoscopy from the Mass General Brigham Colonoscopy Cohort (2007-2023).

Enzymatic characteristics and catalytic mechanisms of opine dehydrogenases from jumbo squid (Dosidicus gigas) for acidic opine formation.

The unpleasant sour off-flavors for Dosidicus gigas greatly affects its flavor and edible value, which is provably attributed to the formation of opines as the characteristic sour compounds. Opine dehydrogenases (OpDHs) play a crucial role in opine formation. Therefore, this study aims to investigate the enzymatic properties of OpDHs and further clarify the catalytic mechanisms of OpDHs mainly including meso-alanopine dehydrogenase (meso-ADH), β-alanopine dehydrogenase (β-ADH), and strobmine dehydrogenase (SDH) for the formation of corresponding opines.

Constructing carboxylated cellulose nanofibers/chitosan aerogel loading with CdS/UiO-66-NH for wastewater treatment: Synergistic adsorption and visible light photocatalytic degradation.

The discharge of industrial effluents containing heavy metal ions and organic dyes has laid heavy burdens on ecosystem, meanwhile, drawing extensive scientific attention globally. In this work, CdS/UiO-66-NH heterojunction was uniformly loading on the aerogel skeleton composed of cellulose (CNF), chitosan (CS) and montmorillonite (MMT). The fabricated composite aerogel noted as CUN-CCMA was equipped with light density, a large specific area and a robust three-dimensional interpenetrating network.

Preparation of g-CN/CoO/NS-CQDs Composite Materials and Their Application in the Detection of Hydrogen Peroxide and Glucose.

g-CN, a biocompatible material, has prominent applications in biology and is ideal for nano-enzyme studies. Though reported as a peroxidase mimic, its activity remains low. This group combined N,S-doped carbon quantum dots (NS-CQDs) with g-CN (7NSC-g), verifying its peroxidase-like activity.

Non-alcoholic fatty liver disease enhances the beneficial effect of renal denervation on gut microbiota aberrations in rats with heart failure.

Background: Renal denervation (RDN) contributes to improving cardiac function by ameliorating aberrations of the gut microbiota, and non-alcoholic fatty liver disease (NAFLD) is associated with gut microbiota dysbiosis and is critically involved in the development of heart failure (HF). It is unclear whether the beneficial effect of RDN on gut microbiota in HF can be affected by NAFLD and whether this effect changes with the severity of NAFLD.

Methods: HF Sprague Dawley rats induced by transverse aortic constriction were fed a high-fat-fructose diet and underwent RDN, and sequencing of 16S rRNA gene in fecal samples was detected.

Tetracera asiatica flavonoids attenuate alcohol-induced liver injury by suppressing oxidative stress and inflammation mediated by the Keap-1/Nrf2/HO-1, NF-κB/MAPK and PERK/Nrf2 signaling pathways in alcoholic liver injury rats.

Alcoholic liver disease is regarded as a leading reason for liver cirrhosis. This study aimed to investigate the protective effect of tetracera asiatica flavonoids (TAF) on alcoholic liver injury (ALI) and explore the associated mechanisms. An ALI rat model was established and then divided into four groups, including ALI group, low-dose TAF (l-TAF) group, medium-dose TAF (m-TAF) group, and high-dose TAF (h-TAF) group.

[Application of growth factors and their mimetics in tissue repair].

Growth factors (GFs) are a class of peptides that facilitate cell growth by binding to specific receptors on the cell membrane. With unique properties, GFs are widely applied in the repair of injured tissue. To address the limitations associated with natural peptide-based GFs and recombinant GFs, researchers have developed diverse GF mimetics.