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http://dx.doi.org/10.1016/j.foodchem.2025.144365 | DOI Listing |
Angew Chem Int Ed Engl
September 2025
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India.
Photoremovable protecting groups (PRPGs) enable precise spatiotemporal control over molecular release and functional activation. Recent advances have introduced wavelength-selective systems for sequential deprotection, broadening applications in drug delivery, material synthesis, and photopolymerization. In parallel, PRPGs play a crucial role in photobase generators (PBGs) and photoacid generators (PAGs), enabling oxygen-tolerant, spatially controlled polymerization and depolymerization through light-induced base and acid release.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
In this study, we successfully developed a diselenide-based, triple-responsive intelligent nanogel, IR780@BEAP, for lung cancer therapy. Exploiting the elevated levels of reactive oxygen species (ROS) and glutathione (GSH) in the tumor microenvironment (TME), a ROS/GSH dual-responsive diselenide cross-linker (DSe5) was synthesized and used to cross-link betulin (BE) with polysaccharide (AP) while coloading the photosensitizer IR780. The resulting nanogel, IR780@BEAP, exhibited an appropriate particle size (137.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Department of Stomatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 611731, China.
Radiation-induced skin injury (RSI) remains a significant clinical challenge due to persistent oxidative stress, chronic inflammation, and impaired tissue regeneration. It is demonstrated that RSI is accompanied by dysregulation of the immune microenvironment, wherein macrophages act as key regulators of all pathological cascades. Here, we developed a dual network hydrogel (Gel/SA@MXene) through dual cross-linking via UV irradiation and calcium ions to accelerate radiation-combined wound healing.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Strain sensors have received considerable attention in personal healthcare due to their ability to monitor real-time human movement. However, the lack of chemical sensing capabilities in existing strain sensors limits their utility for continuous biometric monitoring. Although the development of dual wearable sensors capable of simultaneously monitoring human motion and biometric data presents significant challenges, the ability to fabricate these sensors with geometries tailored to individual users is highly desirable.
View Article and Find Full Text PDFFront Bioeng Biotechnol
August 2025
Department of Sports Medicine, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Speed Capability, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, China.
Introduction: During the healing process, the functional gradient attachment of the rotator cuff (RC) tendon-bone interface fails to regenerate, which severely impedes load transfer and stress dissipation, thereby increasing the risk of retears. As a result, the treatment of rotator cuff tears remains a significant clinical challenge.
Methods: In this study, a dual-crosslinked hyaluronic acid/polyethylene glycol (HA/PEG) hydrogel scaffold was synthesized using hyaluronic acid and polyethylene glycol as base materials.