Enhanced rotator cuff tendon-bone interface regeneration with injectable manganese-based mesoporous silica nanoparticle-loaded dual crosslinked hydrogels.

Introduction: During the healing process, the functional gradient attachment of the rotator cuff (RC) tendon-bone interface fails to regenerate, which severely impedes load transfer and stress dissipation, thereby increasing the risk of retears. As a result, the treatment of rotator cuff tears remains a significant clinical challenge.

Methods: In this study, a dual-crosslinked hyaluronic acid/polyethylene glycol (HA/PEG) hydrogel scaffold was synthesized using hyaluronic acid and polyethylene glycol as base materials.

Resting-state EEG associated with clinical measures to predict upper limb motor recovery of subacute stroke.

Background: After stroke, upper limb dysfunction seriously affects patients' quality of life. The uncertain prognosis of patients poses a challenge for therapists in developing personalized rehabilitation programs. Electroencephalograph (EEG) power spectrum changes during rehabilitation training may have a predictive effect on the improvement of upper limb movement.

Chronic Active Epstein-Barr Virus Myopathy Mimicking Idiopathic Inflammatory Myopathies: A Diagnostic Pitfall, Differentiating Features, and Clinical Impact Revealed in the 10-year Case Series.

Systemic chronic active Epstein-Barr virus disease (sCAEBVD) can primarily involve skeletal muscle to form CAEBV-myopathy (CAEBV-M), which may resemble idiopathic inflammatory myopathies (IIMs). This study reports an 11-patient, 10-year cohort of CAEBV-M to summarize clinicoseropathologic features. CAEBV-M typically affects young adults (median: 29 years), with universal limb swelling, frequent disseminated muscle involvement (73%), and systemic symptoms like fever (82%), splenomegaly (82%), and hemophagocytic lymphohistiocytosis (55%).

Harnessing deep learning to optimize induction chemotherapy choices in nasopharyngeal carcinoma.

Background: Currently, there is no guidance for personalized choice of induction chemotherapy (IC) regimens (TPF, docetaxel + cisplatin + 5-Fu; or GP, gemcitabine + cisplatin) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC). This study aimed to develop deep learning models for IC response prediction in LA-NPC.

Methods: For 1438 LA-NPC patients, pretreatment magnetic resonance imaging (MRI) scans and complete biological response (cBR) information after 3 cycles of IC were collected from two centers.

Spinach SoNRT3 Interacts with SoNRT2a to Improve Low-Nitrogen Tolerance via Nitrate Uptake and Root Growth.

High nitrogen use efficiency is crucial for enhancing spinach's tolerance to low nitrogen stress and minimizing nitrate accumulation. Here, we report that SoNRT3, a NAR2 family protein, modulates nitrate uptake and plant growth under low-nitrate conditions. SoNRT3 expression was induced by low nitrate availability in roots and prolonged nitrogen deficiency in shoots.

Enhanced pre-recruitment framework for clinical trial questionnaires through the integration of large language models and knowledge graphs.

The recruitment of participants for clinical trials has traditionally been a passive and challenging process, leading to difficulties in acquiring a sufficient number of qualified participants in a timely manner. This issue has impeded advancements in medical research. However, recent years have seen the evolution of knowledge graphs and the introduction of large language models (LLMs), providing innovative approaches for the pre-screening and recruitment phases of clinical trials.

Ultra-Narrow Homogeneous Photoluminescence Line Width of Zinc-Blende CdSe-Based Core/Shell Nanocrystals: Dominating Role of Lattice-Ligands Interface.

Homogeneous photoluminescence (PL) line width of semiconductor nanocrystals is usually much greater than thermal broadening at room temperature (∼25 meV), limiting their applications as optical and optoelectronic materials. Here, homogeneous PL line width of zinc-blende CdSe nanocrystals with epitaxially grown CdS, ZnSe, and ZnS shells is studied using single-molecular spectroscopy, confirming that delocalization of electron and hole wave functions to the lattice-ligands interface dictates their PL homogeneous line width. Specially, epitaxial ZnSe (or ZnSe inner and ZnS outer) shells form type-I band offsets with CdSe cores, colocalizing both electron and hole wave functions within the ordered core lattice with minimum lattice strain.

Bacteria-mediated sulfur cycle and cadmium stabilization in an anaerobic-aerobic coupled system.

Although cadmium stabilization through dissimilatory sulfate reduction (DSR), mediated by sulfate-reducing bacteria (SRB) has been extensively studied, the mutual interactions between cadmium and sulfur-cycle systems co-regulated by SRB and sulfur-oxidizing bacteria (SOB) remain poorly characterized. We examined physiological responses (growth kinetics, sulfur valence transitions, Cd tolerance) to determine how bacterially mediated bidirectional sulfur cycling influences cadmium speciation. Results demonstrate that SRB (Enterobacter quasihormaechei) immobilizes Cd anaerobically, forming CdS, as confirmed by XRD, FTIR, and SEM/EDS analyses.

Cultivating microalgal biofilms on three soils under exogenous phosphorus and iron.

Biological crusts serve as the initiator of soil development and play a crucial role in soil ecological restoration. In this study, microalgae biofilms were cultivated on three simulated problem soils (saline soil, limestone, and tufa sand) with the addition of phosphogypsum and pyrite tailings. During the 50-day culture period, chlorophyll-a and exopolysaccharide contents rosed in saline soil and limestone compared to the control group, with significant increases in limestone.

Deep learning-based delineation of whole-body organs at risk empowering adaptive radiotherapy.

Background: Accurate delineation of organs at risk (OARs) is crucial for precision radiotherapy. Most previous autosegmentation models were only constructed for single anatomical region without evaluation of dosimetric impact. We aimed to validate the clinical practicability of deep-learning (DL) models for autosegmentation of whole-body OARs with respect to delineation accuracy, clinical acceptance and dosimetric impact.

Brain structural and functional differences in anejaculation and sleep disorders: A functional magnetic resonance imaging-based approach.

Background And Aims: Sleep disorders (SDs) have been identified as an independent risk factor for ejaculatory dysfunctions; yet the neurophysiological mechanisms underlying the comorbidity between anejaculation (AE) and SDs remain poorly understood. This study aims to investigate the potential pathways that connect SDs and AE, comparing findings across a sample of affected patients and healthy controls (HCs) to better elucidate these complex interactions.

Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were obtained for 21 AE patients, 20 patients with anejaculation accompanied by sleep disorders (AESD), and 18 HCs.

Integrated machine learning and single-cell analysis reveal the prognostic and therapeutic potential of SUMOylation-related genes in ovarian cancer.

Introduction: Ovarian cancer (OC) exhibits high mortality and chemoresistance rates, underscoring the urgent need for precise prognostic biomarkers and novel therapeutic targets. SUMOylation, crucial in cellular stress responses, is frequently dysregulated in various cancers. This study aims to characterize SUMOylation and its regulators in OC and identify potential biomarkers and therapeutic targets.

Remote sensing intelligent interpretation brain: Real-time intelligent understanding of the Earth.

The large-scale understanding of nature and human activities in real time cannot be separated from Earth observation. Existing monitoring techniques, however, rely primarily on offline processing, with a separation between software and hardware in collection, processing and transmission processes. This limits the ability and timeliness in response to emergency tasks such as disaster relief and nighttime rescue.

Epstein-Barr virus infection increases the risk of depression: A cross-sectional study and Mendelian randomization analysis.

Depression, a common psychiatric disorder with multiple causes, has been increasingly linked to viral infections, especially herpesviruses. Epstein-Barr virus (EBV), is a widely infecting Herpesviridae virus. Although some studies have suggested that EBV may be associated with depression, a causal relationship remains unclear.

Isolation of , a Peptidase_M24 Superfamily Gene, Regulating Heading Date in Rice.

The heading date is one of the important traits in rice, which greatly affects grain yield and regional adaptability. Although the flowering pathways in rice have been extensively investigated, the genes involved in flowering remain largely unknown. Here, we report a rice mutant, which showed late flowering under both long-day (LD) and short-day (SD) conditions.

Extracellular Vesicles From Bone Marrow-Derived Macrophages Enriched in ARG1 Enhance Microglial Phagocytosis and Haematoma Clearance Following Intracerebral Haemorrhage.

Microglial phagocytosis of haematomas is crucial for neural functional recovery following intracerebral haemorrhage (ICH), a process regulated by various factors from within and outside the central nervous system (CNS). Extracellular vesicles (EVs), significant mediators of intercellular communication, have been demonstrated to play a pivotal role in the pathogenesis and progression of CNS diseases. However, the regulatory role of endogenous EVs on the phagocytic capacity of microglia post-ICH remains elusive.

Vat Photopolymerization Additive Manufacturing of WC-Co Hardmetals Enabled by In Situ Polymerization-Induced Microencapsulation.

The additive manufacturing of hardmetals has attracted great attention recently but faces significant challenges in low printing resolution and low mechanical strength. Herein, the fabrication of hardmetal parts with complex structures and high surface quality by vat photopolymerization assisted with a sintering process has been achieved. This was enabled by in situ polymerization-induced microencapsulation of WC powder, which simultaneously enhances the photocuring ability and sedimentation stability of the WC-Co slurry.

A Serial MRI-based Deep Learning Model to Predict Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma.

Purpose To develop and evaluate a deep learning-based prognostic model for predicting survival in locoregionally advanced nasopharyngeal carcinoma (LA-NPC) using serial MRI before and after induction chemotherapy (IC). Materials and Methods This multicenter retrospective study included 1039 patients with LA-NPC (779 male and 260 female patients; mean age, 44 years ± 11 [SD]) diagnosed between December 2011 and January 2016. A radiomics-clinical prognostic model (model RC) was developed using pre- and post-IC MRI acquisitions and other clinical factors using graph convolutional neural networks.

Unraveling the spatial distribution and influencing factors of 'Bengke' traditional houses in Luhuo County, Western Sichuan.

The article examines the spatial distribution characteristics and influencing factors of traditional Tibetan "Bengke" residential architecture in Luhuo County, Ganzi Tibetan Autonomous Prefecture, Sichuan Province. The study utilizes spatial statistical methods, including Average Nearest Neighbor Analysis, Getis-Ord Gi*, and Kernel Density Estimation, to identify significant clustering patterns of Bengke architecture. Spatial autocorrelation was tested using Moran's Index, with results indicating no significant spatial autocorrelation, suggesting that the distribution mechanisms are complex and influenced by multiple factors.

CPRS: a clinical protocol recommendation system based on LLMs.

Background: As fundamental documents in clinical trials, clinical trial protocols are intended to ensure that trials are conducted according to the objectives set by researchers. The advent of large models with superior semantic performance compared to traditional models provides fresh perspectives for research recommendations in clinical trial protocols.

Method: A clinical trial protocol recommendation system based on Large Language Models (LLMs) is proposed in this paper, combining GPT-4 and knowledge graph to assist in clinical trial protocol recommendations.

Lycium barbarum Extract Enhanced Neuroplasticity and Functional Recovery in 5xFAD Mice via Modulating Microglial Status of the Central Nervous System.

Objective: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease with limited treatment options. This study aimed to investigate the effects of Lycium barbarum extract (LBE), a Chinese herb, on the central nervous system (CNS)-including the retina, brain, and spinal cord-in 5xFAD transgenic mice after the onset of AD.

Methods: Starting at 6 months of age, 5xFAD mice received daily intragastric gavage of LBE (2 g/kg) for 2 months.

Immunoregulation in Skull Defect Repair with a Smart Hydrogel Loaded with Mesoporous Bioactive Glasses.

Skull defect repair is a complex and critical medical challenge, and there is an urgent need to develop multifunctional tissue engineering scaffolds for skull regeneration. The success of bone tissue engineering depends on the construction of scaffolds that can regulate the immune microenvironment of bone regeneration and mimic the liquid crystal and viscoelastic properties of natural bone extracellular matrix. Hence, a smart hydrogel (PEGDA5/AM15/CLC-BMP-4@MBG) with good biocompatibility and the ability to modulate the wound immune microenvironment has been developed for the repair of skull defects.

Efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in anejaculation: A randomized controlled trial.

Background: Anejaculation represents significant psychological distress and sexual and reproductive challenges among male individuals and couples. Effective fertility management options are available to address the reproductive challenges associated with anejaculation. However, there is a lack of methods to reverse the condition itself.

Identification of UNC5B as a novel aggressive biomarker for osteosarcoma based on basement membrane genes.

Background: The prognosis of patients with metastatic osteosarcoma is poor, and the variation of basement membrane genes (BMGs) is associated with cancer metastasis. However, the role of BMGs in osteosarcoma has been poorly studied.

Methods: BMGs were collected and differentially expressed BMGs (DE-BMGs) were found through difference analysis.