Investigation into Antibiotic Resistance Profiles of Among Chronic Rhinosinusitis Patients and Multifaceted Analysis of Factors Influencing Methicillin-Resistant Infection.

Objective: This study aimed to comprehensively investigate the antibiotic resistance characteristics of in chronic rhinosinusitis (CRS) patients and to identify key determinants influencing the development of methicillin-resistant Staphylococcus aureus (MRSA) infections.

Methods: A retrospective analysis was conducted on 180 CRS patients admitted to our hospital between February 2022 and July 2024. Nasal secretion samples were collected upon admission for strain isolation, and antibiotic susceptibility testing was performed using an automated microbiology system.

Viral infection-induced CD97 upregulation facilitates viral invasion by interacting with viral proteins.

Virus-host interactions are crucial for regulating viral replication. While some interactions can suppress viral spread, others may promote it, and their underlying mechanisms remain poorly understood. Here, we report that infection with bovine herpesvirus 1 (BoHV-1) or bovine ephemeral fever virus (BEFV) upregulates the transcriptional expression of Cluster of Differentiation 97 (CD97).

Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotransposition.

Gene duplication generates gene paralogs that may undergo diverse fates during evolution, and thus serves as a potent catalyst of biological complexity. Genetic paralogs frequently share redundant functions and may also exhibit antagonistic activities by competing for common interaction partners. Here we show that the gene paralogs NRBP1 and NRBP2 oppositely regulate long interspersed nuclear element-1 (L1) retrotransposition, via influencing integrity of the L1 ribonucleoprotein complex.

Highly selective electrochemiluminescence enhanced detection of ascorbic acid in tablets and beverages utilizing Ru(bpy)-embedded zirconium-based metal-organic frameworks.

A novel electrochemiluminescence (ECL) enhanced method for sensitive, selective and accurate ECL detection of ascorbic acid (AA) is developed using tris (2,2'-bipyridine) ruthenium (II) (Ru(bpy)) embedded into zirconium-based metal-organic frameworks (Ru(bpy)@UiO-67 MOFs). AA is oxidized by cerium ion (Ce) into dehydroascorbic acid (DHA) and hydrolyzed into 2,3-diketogulonic acid (DKG). The oxidation product DKG has α-keto acid structure and can form acyl radical, which enhances the ECL of Ru(bpy)@UiO-67 MOFs nearly 220 times.

Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and Dexamethasone.

Objective: To analyze the clinical symptom improvement and recurrence rate of chronic suppurative otitis media (CSOM) patients treated with a combination therapy regimen (combination of ofloxacin and dexamethasone).

Methods: Based on the treatment regimen, patients were divided into two groups: the control group was treated with dexamethasone, while the treatment group received a combination of ofloxacin and dexamethasone. The clinical symptom improvement, hearing evaluation, pathogen clearance rate, inflammatory marker detection, adverse reactions, recurrence rate and recurrence rate post-treatment were compared between the two groups.

Physiological Adaptations of to Heavy Metal Stress: Soluble Sugar Accumulation and Biomass Enhancement.

Background: Heavy metal contamination significantly threatens crop growth and global food security. Understanding plant responses to such stress is crucial to developing stress-tolerant crops. This study explores the physiological and biochemical responses of (L.

Polyneuritis cranialis combined with Horner's syndrome: a rare variant of Guillain Barré syndrome.

Background: Polyneuritis cranialis (PNC), a rare variant of Guillain-Barré syndrome (GBS), is usually characterized by ocular and pharyngeal weakness without obvious numbness or weakness of the limbs or ataxia. Horner's syndrome is extremely rare in patients with PNC. Here, we describe a case of GBS presenting with acute PNC and unilateral Horner syndrome.

SCARA5 might be one potential marker for CC and promoted Ferroptosis by FTL.

The current investigation sought to explore the effects and its possible mechanisms of Scavenger receptor class A member 5 (SCARA5) in model of colon cancer (CC). Patients diagnosed with CC were recruited from our hospital. SCARA5 mRNA expression levels in patients with CC was reduced, and the expression of SCARA5 mRNA in patients with I-II was higher than that of patients with III-IV.

SATB1 in cancer progression and metastasis: mechanisms and therapeutic potential.

Cancer remains a major global health challenge, with prostate cancer, lung cancer, colorectal cancer, and breast cancer accounting for nearly half of all diagnoses. Despite advancements in cancer treatment, metastasis to distant organs continues to be the leading cause of cancer-related mortality. The progression of cancer involves the alteration of numerous genes, with dynamic changes in chromatin organization and histone modifications playing a critical role in regulating cancer-associated genes.

p53-dependent chromatin relaxation is required for DNA double-strand break repair.

The tumor suppressor p53, an indispensable nuclear transcription factor, plays a central role in orchestrating cellular responses when DNA damage occurs. In this study, we demonstrate that in the initial phases of DNA double-strand break (DSB) repair, p53 is rapidly recruited to sites of damage and the surrounding chromatin, where it enhances DSB repair efficiency. This enhancement occurs through the modulation of chromatin dynamics and the promotion of a more relaxed chromatin configuration, a process influenced by p53 in response to DSB-inducing factors such as etoposide, ultraviolet radiation, and nucleases.

The genetic variation of mitochondrial sequences and pathological differences of strains from different continents.

Alveolar echinococcosis is a lethal zoonotic disease caused by the fox tapeworm . The parasite is widely distributed in the Northern Hemisphere and exhibits low genetic diversity among populations. To compare the differences among four strains from different geographical locations, namely, Alaska (EM-AK), Japan (EM-JP), Xinjiang (EM-XJ), and Ningxia (EM-NX), their complete mitochondrial (mt) sequences were compared, and their induced pathological lesions were analyzed in mouse models.

Application of efgartigimod in Chinese patients with myasthenia gravis: a single-center real-world prospective study.

Background: China has a large number of myasthenia gravis (MG) patients, creating an urgent need for rapid and tolerable treatment options. As the first-approved Fc receptor antagonist, efgartigimod has bright prospects for treating MG. However, real-world evidence on its application within the Chinese MG population are limited.

[Clinical characteristics and prognosis of acute erythroleukemia in children].

Objectives: To investigate the clinical characteristics and prognosis of acute erythroleukemia (AEL) in children.

Methods: A retrospective analysis was conducted on the clinical data, treatment, and prognosis of 8 children with AEL treated at the First Affiliated Hospital of Zhengzhou University from January 2013 to December 2023.

Results: Among the 7 patients with complete bone marrow morphological analysis, 4 exhibited trilineage dysplasia, with a 100% incidence of erythroid dysplasia (7/7), a 71% incidence of myeloid dysplasia (5/7), and a 57% incidence of megakaryocytic dysplasia (4/7).

Readiness potentials changed by decision-making in the chicken game.

The chicken game, a well-established social dilemma paradigm, is widely used to study cooperative and competitive behaviors. Strategic decision-making in this game is influenced by the outcomes of cooperative and competitive interactions, with feedback-related event-related potentials (ERPs) during the feedback phase being a primary research focus. However, it remains unclear whether specific ERP components associated with strategic decision-making are present during the response phase.

Identification of serum biomarkers for cystic echinococcosis in sheep through untargeted metabolomic analysis using LC-MS/MS technology.

Background: Echinococcosis is a zoonotic disease caused by an Echinococcus tapeworm infection. While diagnostic methods for humans often rely on ultrasound imaging and immunodiagnostic techniques, diagnosis in intermediate hosts typically has no widely used diagnostic markers, hampering disease control efforts.

Methods: The differences in serum metabolites of sheep infected with Echinococcus granulosus and a control group were analyzed using ultrahigh-performance liquid chromatography (UHPLC) separation with tandem mass spectrometry (MS/MS) detection.

Differences in embodied cognition between the arrow-orientation and the arrow-position recognition tasks: evidence from event-related potentials.

Embodied cognition is known to play a role in verbal semantic processing. However, its involvement in nonverbal semantic elements, such as arrows, is less understood. Two spatial recognition tasks, specifically arrow-orientation recognition and arrow-position recognition, were employed using directional arrows in various spatial arrangements as visual stimuli.

[Application of high-throughput drug sensitivity testing in children with relapsed and refractory acute leukemia].

Objectives: To explore the current application of high-throughput drug sensitivity (HDS) testing in children with relapsed and refractory acute leukemia (RR-AL) and analyze the feasibility of salvage treatment plans.

Methods: A retrospective collection of clinical data from children with RR-AL who underwent HDS testing at the Department of Children's Hematology and Oncology of the First Affiliated Hospital of Zhengzhou University from November 2021 to October 2023 was conducted, followed by an analysis of drug sensitivity results and treatment outcomes.

Results: A total of 17 children with RR-AL underwent HDS testing, including 7 cases of relapsed refractory acute myeloid leukemia and 10 cases of relapsed refractory acute lymphoblastic leukemia.

A case of X-Linked adrenoleukodystrophy caused by a novel mutation with singular clinical manifestation: unilateral lower limb weakness.

X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene, leading to the accumulation of very long-chain fatty acids (VLCFAs) in plasma and tissues. It primarily affects the central nervous system white matter and the adrenal cortex. Clinical manifestations include myeloneuropathy, leukodystrophy, and adrenal insufficiency.

A Graded Redox Interfacial Modifier for High-Performance Perovskite Solar Cells.

Perovskite solar cells have emerged as a potential competitor to the silicon photovoltaic technology. The most representative perovskite cells employ SnO and spiro-OMeTAD as the charge-transport materials. Despite their high efficiencies, perovskite cells with such a configuration show unsatisfactory lifespan, normally attributed to the instability of perovskites and spiro-OMeTAD.

Repurposing of a library for high-content screening of inhibitors against Echinococcus granulosus.

Background: Cystic echinococcosis (CE) is a zoonotic disease caused by the larval stage of the dog tapeworm Echinococcus granulosus sensu lato (E. granulosus), with a worldwide distribution. The current treatment strategy for CE is insufficient.

A female adult-onset X-ALD patient with pure cerebellar symptoms:a case report.

X-linked adrenoleukodystrophy (X-ALD) caused by ATP-binding cassette subfamily D member 1 () gene defects is the most common inherited peroxisomal disorder.The female cerebello-brainstem dominant type in which cerebellum and brainstem are mainly involved is very rare. We report a 40-year-old female who was diagnosed as the rare disorder with magnetic resonance imaging (MRI) and genetic analysis mainly.

Novel cathodic and anodic dual-emitting electrochemiluminescence of Ru(bpy)/α-keto acid system.

Novel cathodic and anodic dual-emitting electrochemiluminescence (ECL) of Ru(bpy) and α-keto acids system are studied for the first time. Based on their cathodic and anodic ECL intensity, α-keto acids including oxalate, glyoxylic acid, pyruvic acid, and phenylglyoxylic acid can be directly sensitively detected. The limits of detection (LOD) of oxalate, glyoxylic acid, pyruvic acid, and phenylglyoxylic acid are 31.

Case report: Rapid clinical improvement in acute exacerbation of MuSK-MG with efgartigimod.

Myasthenia gravis with positive MuSK antibody often involves the bulbar muscles and is usually refractory to acetylcholinesterase inhibitors. For MuSK-MG patients who experience acute exacerbations and do not respond to conventional treatments, there is an urgent need to find more suitable treatment options. With the advent of biologic agents, efgartigimod has shown promising results in the treatment of MG.