Factors influencing reproductive concerns and their correlation with quality of life among adolescents and young adults with acute leukaemia in Hunan province, China: a cross-sectional study.

Objective: This study aimed to examine the reproductive concerns and their influencing factors among adolescents and young adults with acute leukaemia and to explore the relationship between reproductive concerns and patients' quality of life.

Design: A cross-sectional study.

Setting: The haematology departments of four tertiary-level hospitals in Hunan province, China.

Maimendong decoction and its active ingredient, ophiopogonin D, alleviate bleomycin-induced pulmonary fibrosis by regulating the behavior of lung fibroblasts.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by progressive scarring of lung tissue, which can lead to respiratory failure and other serious complications, making the search for safe and effective therapeutic agents an urgent priority; Maimendong Decoction (MMDD), a traditional Chinese herbal formula widely employed in clinical practice to treat pulmonary disorders, has been shown to reduce inflammatory cytokines, suppress pro-fibrotic factors, and alleviate oxidative stress, yet the precise mechanisms by which MMDD exerts its anti-fibrotic effects remain unclear.

Purpose: This study aims to evaluate the therapeutic efficacy of MMDD in pulmonary fibrosis and to elucidate its underlying mechanisms.

Methods: Using a bleomycin (BLM)-induced mouse model of idiopathic pulmonary fibrosis, we assessed the therapeutic impact of MMDD on pulmonary fibrosis; concurrently, Ophiopogonin-D (OP-D), a principal active ingredient of MMDD, was evaluated in an in vitro human fetal lung fibroblast model treated with transforming growth factor-β (TGF-β) to elucidate its precise anti-fibrotic mechanism; finally, multi-omics technologies and bioinformatics analyses were employed for comprehensive validation.

Self-healing Cu single-atom catalyst for high-performance electrocatalytic CO methanation.

To address the escalating challenge of atmospheric CO emissions, this study proposes a self-healing Cu single atom (SA) catalyst design. By partially cleaving Cu-N bonds via hydrogen evolution reaction (HER), coordinatively unsaturated Cu sites form and spontaneously bond with adjacent ZrO clusters which are strategically positioned near the Cu SA, creating a hybrid Cu-N/O structure with enhanced performance. In situ Raman and X-ray absorption fine structure (XAFS) measurements confirm the dynamic reconstruction of coordination environment from CuN to CuNO under electrochemical conditions.

Exploring nurses' knowledge, attitudes, and competence in holistic palliative care management in Papua New Guinea: a mixed-methods study.

Background: Palliative care is crucial for enhancing the quality of life for terminally ill patients, like those with cancer, but only 14% of those in need receive it, especially in resource-limited areas like Papua New Guinea (PNG). In 2018, PNG reported 7,477 cancer deaths and 11,913 new cases, with a projected 79% increase in patients by 2040. Nurses are vital to palliative care, yet gaps in competencies, particularly in pain management, affect care quality.

How Exploitative Leadership Emerges: The Activating Effect of Organizational Context on Individual Traits.

Although the detrimental effects of exploitative leadership have been widely revealed, scholarly understanding of its formation mechanisms remains insufficient. Addressing this gap, the present study draws upon trait activation theory to investigate the antecedents and formation mechanisms of exploitative leadership through the dual lenses of personality traits and organizational contexts. Through an empirical examination of questionnaire data from 422 leader-subordinate dyads in Chinese organizations, the results of this study reveal that: three leader personality traits-self-interest, other-oriented perfectionism, and high power distance orientation-significantly and positively predict exploitative leadership behaviors; three organizational contexts-task challenge, flexible status conferral, and leader-subordinate goal misalignment-likewise serve as positive predictors of exploitative leadership behaviors; through trait activation effects, flexible status conferral significantly strengthens the positive relationships between all three personality traits and exploitative leadership, while task challenge and goal misalignment specifically amplify the positive relationships of exploitative leadership with high power distance orientation and self-interested personality, respectively.

BioLLM: A standardized framework for integrating and benchmarking single-cell foundation models.

The application and evaluation of single-cell foundation models (scFMs) present significant challenges due to heterogeneous architectures and coding standards. To address this, we introduce BioLLM (biological large language model), a unified framework for integrating and applying scFMs to single-cell RNA sequencing analysis. BioLLM provides a unified interface that integrates diverse scFMs, eliminating architectural and coding inconsistencies to enable streamlined model access.

Exploring the biological basis for the identification of different syndromes in ischemic heart failure based on joint multi-omics analysis.

Background: IHF is a major chronic disease that seriously threatens human health. Qi deficiency and blood stasis syndrome (QDBS), Yang deficiency with blood stasis syndrome (YDBS) and Yang deficiency and blood stasis with fluid retention syndrome (YDBSFR) are the basic syndromes of IHF in Chinese medicine. This study aims to explore the biological basis of the three IHF syndromes through integrated multi-omics research.

Stable Metal-Organic Electrocatalysts for Anion-Exchange Membrane Water Electrolyzers by Defect Engineering.

Developing efficient and durable catalysts for the alkaline oxygen evolution reaction (OER) is vital to achieving practical anion-exchange membrane water electrolyzers (AEMWEs) for green hydrogen production. Here, we break the activity-stability trade-off of electrocatalysis by defect engineering of Ni-based metal-organic electrocatalysts (Ni-benzenedicarboxylate; Ni-BDC) through coordinating ferrocenecarboxylates (Fc) to the metal sites. Experimental results collectively reveal that the defect MOF (Ni-BDC:Fc_5:1) exhibits a high OER turnover frequency of 0.

Wumei Wan remodels the tumor immune microenvironment via the Ido1-KYN-AHR axis in AOM/DSS-induced colorectal cancer model.

Background: Colorectal cancer(CRC) is a prevalent malignancy of the digestive tract, with poor prognosis in advanced stages due to metastasis and immune evasion. Chronic intestinal inflammation is increasingly recognized as a key driver of CRC progression by disrupting the immune microenvironment.Wumei Wan(WMW),a traditional Chinese herbal formula,has shown anti-inflammatory efficacy in ulcerative colitis,but its potential to inhibit CRC and modulate the immune microenvironment remains unclear.

The interplay between perceived stress, academic control, achievement motivation, and procrastination among nursing graduate students: A network analysis.

Background: Procrastination is common among nursing graduate students and is linked to poor academic performance, student attrition, and various potential physical and mental health issues. In light of the global nursing shortage, understanding the factors that contribute to procrastination is essential for developing effective interventions to mitigate its impact.

Objectives: This study aimed to examine the associations between perceived stress, academic control, achievement motivation, and procrastination among nursing graduate students through network analysis.

Impact of Adjuvant Analgesics on Outcomes of Spinal Cord and Peripheral Nerve Stimulation: A Scoping Review.

Introduction: Spinal cord stimulation (SCS) and peripheral nerve stimulation (PNS) are used to treat refractory pain, but even well-selected patients can fail to have analgesic benefit following implantation. The analgesia afforded by SCS/PNS may be enhanced or attenuated by the ongoing use of analgesic medications that are often consumed by patients who receive SCS and PNS implants. We undertook a scoping review to scan and summarize the evidence for impact of adjuvant pharmacotherapy on SCS and PNS therapy in animal and human settings.

Tough Cellulose Hydrogel Electrolyte with Low Solvation for Highly Reversible and Flexible Aqueous Zinc-Ion Battery.

Recent advancements in hydrogel electrolytes for aqueous zinc-ion batteries (AZIBs) have drawn considerable interest due to their soft nature, offering potential to overcome challenges including reversibility and flexibility. As the most abundant natural polymer, cellulose is ideal for AZIB hydrogel electrolytes due to rich hydroxyls with stable hydrogen-bonded networks for water retention. However, conventional cellulose hydrogels suffer from low Zn conductivity and insufficient mechanical robustness, usually requiring additional polymers to meet practical demands.

Sedentary lifestyle, physical activity, and aging: evidence from genetic correlation and mendelian randomization.

Background: Observational studies have shown that physical activity and sedentary behavior are associated with aging. However, whether these associations underlie causal effects remains unknown. Thus, this study aimed to assess the genetic correlation and causal relationships between genetically predicted physical activity, sedentary behavior, and aging.

Integrating multi-omics and machine learning strategies to explore the "gene-protein-metabolite" network in ischemic heart failure with Qi deficiency and blood stasis syndrome.

Background: Ischemic heart failure (IHF) is a multifaceted syndrome associated with significant mortality and high hospitalization rates globally. According to traditional Chinese medicine (TCM) theory, Qi Deficiency and Blood Stasis (QXXY) Syndrome serves as the pathological basis of IHF. This study aims to investigate the biological basis of QXXY syndrome in IHF patients through an integrated multi-omics approach.

CLU, FOS, and CXCL8 as diagnostic biomarkers for heart failure progression post-acute myocardial infarction: an integrated RNA-Seq and multi-machine learning study.

Background: Heart failure (HF) secondary to acute myocardial infarction (AMI) remains a public health concern. Peripheral blood mononuclear cells (PBMCs) are the essential initiators of heart failure after myocardial infarction (HFpAMI). We aimed to identify PBMCs-related critical genes as diagnostic biomarkers for HFpAMI and analyze the immune infiltration patterns.

A Short, All-Oral Regimen for Pre-Extensively Drug-Resistant Tuberculosis: A Multicenter Open-label Single-arm Study.

Background: Pre-extensively drug-resistant tuberculosis (pre-XDR-TB) remains a critical public health threat due to limited treatment options and significant disease burden. Existing regimens have shown high success rates but are often inaccessible globally, necessitating alternative options.

Methods: This study was an open-label, multicenter, single-arm study conducted in China to evaluate the efficacy and safety of a 6- to 9-month oral regimen.

enhanced immune responses and the resistance to infection in pearl gentian groupers.

(MO) is a kind of traditional Chinese herbs, which has been studied for thousands of years in Chinese pharmacopoeia. In recent years, MO has been reported as an antibacterial agent in aquaculture, but the antibacterial properties of MO against infection in fish remains unexplored. In this study, the effects of MO treatment on immune responses and the resistance to infection were detected in pearl gentian groupers.

Metabolomic biomarkers could be molecular clocks in timing stroke onset.

The preferred treatment for acute ischaemic stroke (AIS) is intravenous thrombolysis (IVT) administered within 4.5 hours (h) of symptom onset. This study aimed to identify metabolomic biomarkers for distinguishing AIS patients within 4.

Kidney hepcidin protects the collecting duct against ferroptosis in ischemia/reperfusion-induced acute kidney injury.

Introduction: Ischemic acute kidney injury (AKI) frequently occurs in the intensive care unit. However, early diagnosis is challenging, and specific treatment strategies are still lacking. Here, our study identified endogenous hepcidin was induced with increasing severity of ischemia/reperfusion (I/R) injury mostly in collecting duct (CD) principal and intercalated cells.

Identification of patient-reported core information needs and associated factors in hospitalized patients with heart failure: A network analysis.

Background: The lack of identified core information needs in patients with heart failure significantly hinders the development and implementation of personalized educational interventions.

Objectives: The purpose of this study was to identify the core information needs and explore the factors associated with information needs in patients with heart failure.

Methods: A total of 307 inpatients with heart failure were recruited from three cardiovascular units of a general hospital between February and December 2023.

BaDuShengJi hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti-bacteria, anti-inflammation and promoting epithelialization.

Bacterial infection, excessive inflammation, and delayed re-epithelialization are the biggest obstacles to diabetic wound healing and burn injuries. As a classic prescription, BaDuShengJi San (BDS) has been proven to accelerate chronic wound healing through anti-bacterial and anti-inflammatory mechanisms. However, there are few reports on its role in preventing the malignant progression of deep burns or accelerating deep burn wound healing.

Multitarget Generate Electrolyte Additive for Lithium Metal Batteries.

Electrolyte additives are crucial for accelerating the commercialization of lithium metal batteries (LMBs), yet designing effective additives is challenging due to the need to balance conflicting properties, such as eectrochemical performance and nonflammability. To address this challenge, a deep learning-assisted generative model is developed for multiobjective optimization of electrolyte additives. Overcoming data scarcity, the dataset is expanded using a molecular categorization derivation method, increasing single-property data points to 70 095 multiproperty data points.

Exposure of Hydrogen Silsesquioxane in Electron Beam Lithography.

Hydrogen silsesquioxane (HSQ) offers high-resolution patterning capabilities in electron beam lithography. However, electron scattering within the resist remains challenging to detect, complicating the process control. Since previous research primarily focused on minimizing forward scattering by employing thin resist layers, this work specifically investigates scattering behavior using a thick HSQ resist (∼1 μm).

Covalent organic framework membranes for rechargeable electrochemical energy storage devices: chemistry, fabrication, and future opportunities.

Covalent organic frameworks (COFs) are crystalline porous polymers formed by linking organic monomers through covalent bonds. Their exceptional surface areas, uniform pore structures and adjustable chemical properties make COFs highly promising for ion conduction and selection. Advances in COF chemistry now allow modifications at molecular and atomic scales.