Publications by authors named "Kailei Nong"
Objective: To provide up-to-date evidence on key benefits, harms, and uncertainties regarding medications for adults with type 2 diabetes.
Design: Living systematic review and network meta-analysis (NMA), using frequentist random effects and GRADE (grading of recommendations, assessment, development and evaluation) approaches. Updates are planned at least two times a year.
Chinese expert consensus on the management of hypertension in adults with type 2 diabetes.
J Evid Based Med
December 2024
Article Synopsis
- Hypertension and type 2 diabetes contribute to an increased risk of premature death and related diseases, particularly affecting the same population.
- An expert consensus using the GRADE approach was formed to create strategies aimed at reducing cardiovascular and kidney-related deaths while minimizing treatment burdens for adults with type 2 diabetes.
- A multidisciplinary team developed 12 evidence-based recommendations focusing on screening, monitoring, lifestyle changes, and medication for individuals with type 2 diabetes, specifically addressing those who also have hypertension.
Article Synopsis
- Pharmacotherapy can help adults with overweight and obesity lose weight when lifestyle changes aren't effective, and recent studies provide insights into the effectiveness and safety of these drugs.
- A systematic review identified 132 randomized trials involving over 48,000 participants, concluding that all weight-lowering medications significantly outperformed lifestyle changes in reducing body weight.
- Phentermine-topiramate emerged as the most effective option, while some drugs, including naltrexone-bupropion and GLP-1 receptor agonists, were linked to a higher risk of adverse events leading to treatment discontinuation, although semaglutide demonstrated significant benefits without escalating risks.
Exercise for sarcopenia in older people: A systematic review and network meta-analysis.
J Cachexia Sarcopenia Muscle
June 2023
Background: Sarcopenia is a serious public health concern among older adults worldwide. Exercise is the most common intervention for sarcopenia. This study aimed to compare the effectiveness of different exercise types for older adults with sarcopenia.
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- The study aims to evaluate the pros and cons of various drug treatments for adults with type 2 diabetes, including new options like non-steroidal mineralocorticoid receptor antagonists and tirzepatide.
- A systematic review and meta-analysis was conducted on data from 816 trials involving over 471,000 patients, focusing on drug classes with a follow-up period of at least 24 weeks.
- Findings indicate that SGLT-2 inhibitors and GLP-1 receptor agonists significantly lower the risk of all-cause death and cardiovascular events, while finerenone shows potential in reducing hospitalization for heart failure, although certainty of evidence varies for other drugs.
Background: Pharmacotherapy provides an option for adults with overweight and obesity to reduce their bodyweight if lifestyle modifications fail. We summarised the latest evidence for the benefits and harms of weight-lowering drugs.
Methods: This systematic review and network meta-analysis included searches of PubMed, Embase, and Cochrane Library (CENTRAL) from inception to March 23, 2021, for randomised controlled trials of weight-lowering drugs in adults with overweight and obesity.
Purpose: The necessity to cease anticoagulation before photoselective vaporization (PVP) surgery remains nonconsensual. We aimed at assessing the efficacy and safety of PVP among high-risk benign prostate hyperplasia (BPH) patients on or off anticoagulation.
Methods: We systematically searched Pubmed, Embase, and Cochrane Library Central Register of Controlled Trials (CENTRAL).