The effect of hormonal contraceptives combined with vitamin D3 supplements on sexual dysfunction in women with polycystic ovary syndrome: a randomized double-blind placebo-controlled trial.

Background: Polycystic ovary syndrome (PCOS) is characterized by reproductive and endocrine abnormalities.

Objective: The present study aimed to assess the effect of oral contraceptive pills (OCPs) and vitamin D3 on sexual dysfunction in women with PCOS and vitamin D3 deficiency.

Materials And Methods: This randomized double-blind placebo-controlled clinical trial was conducted in Iran between January and April 2019.

Spatial Transcriptomics and Single Cell-RNASeq Reveals Cellular Heterogeneity of SARS-CoV-2 in Lung Tissues and Global Mutational Patterns in COVID-19 Patients.

RNA viruses have high mutation frequency, quick generation periods and vast population numbers, which promote fast evolution and host environment adaptation. We integrated scRNA-seq and spatial transcriptomics to profile immune cells and viral gene expression in COVID-19. Cell types and interactions were identified using Seurat-based tools.

The Role of Pioglitazone as a Ferroptosis Inhibitor in Mitigating Radiation-Induced Damage in Testicular Tissue of Mice.

Introduction: Radiation targets cancer but risks causing infertility by damaging sensitive testes, especially spermatogonia. This study investigates IR-induced testicular damage and assesses PGZ's potential protective role as a ferroptosis inhibitor.

Material & Methods: In this study, Seventy-two BALB/c mice were randomly divided into eight groups: a control, PGZ (10, 20, and 30 mg/kg), IR (8 Gy), and IR+ PGZ (in three doses).

Artificial Intelligence Challenges in the Healthcare Industry: A Systematic Review of Recent Evidence.

While AI is essential to the development of electronic health, it has challenges that, if resolved, might improve the standard of healthcare services. The purpose of this study is to classify and identify these issues in the healthcare field. The study utilised a systematic review approach, drawing data from the Scopus, Web of Science, and PubMed databases.

Psychometric assessment of the attitude towards menopause checklist: A Persian version.

This study aimed to develop and evaluate the psychometric properties of the Attitude Toward Menopause (ATM) Checklist within the Iranian cultural context. Data were collected in 2017 from a total of 700 postmenopausal women residing in Semnan and Khorasan Razavi provinces. Content validity was assessed by a panel of eight experts using the Lawshe method and Content Validity Index (CVI), resulting in the elimination of 11 items that did not meet the required thresholds.

The association between troponin positivity and adverse clinical outcomes, echocardiographic findings, and mortality in hospitalized patients with COVID-19.

Background: Troponin-I elevation during a COVID-19 infection is likely due to multiple factors. Few studies have investigated the relationship between troponin levels and echocardiographic variables in patients with COVID-19. Our study aimed to evaluate the clinical and paraclinical effects-including echocardiographic findings-of COVID-19 on myocardial injury, as indicated by elevated troponin levels, and to assess its potential impact on in-hospital and three-month outcomes in hospitalized COVID-19 patients.

Possible association between Toxoplasma gondii infection and autism spectrum disorder.

Toxoplasma gondii is a neurotropic apicomplexan protozoan estimated to affect approximately 30% of the global population. In this review, we aimed to examine scientific evidence on the potential role of T. gondii infection in the development of autism spectrum disorder (ASD), a heterogeneous neurodevelopmental disorder.

IRANCANSURV: A comprehensive analysis of childhood cancer survival in Iran.

We aimed to assess the 5-year survival probability of childhood cancer in Iran, utilizing data from eight population-based cancer registries across the country. The study employed data from 1809 childhood cancer patients aged 0-14 years, diagnosed between 2014 and 2016. Patients underwent active and passive follow-up procedures, and cases with uncertain vital status were excluded.

The ameliorative effects of L-arginine on testicular and genotoxic toxicity induced by chronic exposure to cadmium chloride in male murine models.

Cadmium (Cd) is a toxic heavy metal known to cause DNA damage, genetic alterations, and reproductive issues in males through free radical production. This study investigates L-arginine, an amino acid with antioxidant and metal-chelating properties, in mitigating Cd-induced genetic and reproductive toxicity in male mice. Thirty-six male mice were divided into six groups: a control group, a Cd group (2 mg/kg), three groups receiving Cd (2 mg/kg) combined with L-arginine (50, 100, 200 mg/kg), and a positive control group receiving vitamin C (500 mg/kg) with Cd.

Investigating the prevalence of class 1, 2, and 3 integrons in carbapenem-resistant Acinetobacter baumannii isolated from burn wound infections.

Acinetobacter baumannii is a significant antibiotic-resistant pathogen with high morbidity and mortality in hospitalized patients, especially in burn units. Acquiring mobile genetic elements, such as integrons, is significant in developing multidrug-resistant (MDR) hospital isolates. Therefore, this study aimed to determine the prevalence of class 1, 2, and 3 integrons in A.

Bidirectional association between cognitive impairment and bone mineral density reduction in aging populations: A systematic review and meta-analysis of osteoporosis, osteopenia, and bone mineral content.

Osteoporosis is a skeletal disorder characterized by reduced bone mineral density (BMD), increasing fracture risk. Cognitive disorders (CD), including Alzheimer's disease, dementia, and mild cognitive impairment (MCI), cause cognitive decline and are prevalent among older adults. This systematic review and meta-analysis explores the bidirectional association between cognitive impairment and bone health, specifically low BMD, osteopenia, and osteoporosis.

Methanolic extract and nanosilver of Feijoa sellowiana reduce Salmonella typhimurium infection in female BALB/c mice.

Increasing resistance to antibiotics has led to research into new treatment options. Recent studies suggest the use of plant extracts as an alternative strategy. Feijoa is widely known for its efficacy against a broad spectrum of bacterial pathogens.

Evaluation of p53 Gene Mutations in Oral Lichen Planus Lesions in a Population From Iran.

Objectives: Oral lichen planus (OLP) is a chronic inflammatory disorder of the oral mucosa, genetic and molecular alterations, including mutations in the p53 tumor suppressor gene, have been implicated in OLP pathogenesis. However, its molecular mechanisms are not clearly understood. This study investigates p53 gene mutations in OLP lesions.

A study of demographic and clinical characteristics of consumers of non-steroidal anti-inflammatory drugs: a large population-based study utilizing enrollment phase data from the tabari cohort.

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for managing pain and inflammatory conditions. However, their usage patterns and associated risk factors in the general population remain insufficiently understood, particularly in the Iranian context. This study aims to explore the epidemiological and clinical factors associated with NSAID consumption in a population-based cohort.

Ethnic Violence Among Adolescents in Educational Settings: A Systematic Review.

As ethnic diversity increases in schools, it"s vital to understand the dynamics of ethnic violence, which can negatively impact student well-being and academic achievement. Addressing the issue requires recognizing the complexities of ethnic diversity, promoting inclusivity, and implementing targeted interventions to prevent and mitigate violence. This systematic review focuses on understanding the multiple levels of factors that contribute to ethnic violence among adolescents within school settings.

Kinematically aligned total knee arthroplasty is as effective in severe varus deformities as in mild deformities.

Purpose: This study compares the clinical outcomes and radiological measures of kinematic alignment total knee arthroplasty (KA-TKA) in patients with severe knee deformities to those with mild varus.

Methods: This retrospective cohort study included 145 patients with <10° varus malalignment and 145 patients with >10° varus. All cases underwent KA-TKA performed by a single surgeon using the same techniques between 2015 and 2022.

Insights into Persian Gulf Beach Sand Mycobiomes: Promises and Challenges in Fungal Diversity.

Beach Sand Mycobiome is currently among the most important health challenges for viticulture in the world. Remarkably, the study of fungal communities in coastal beach sand and recreational waters remains underexplored despite their potential implications for human health. This research aimed to assess the prevalence of fungal species and the antifungal susceptibility profiles of fungi recovered from the beaches of the Persian Gulf and the Sea of Oman.

Machine Learning-Driven radiomics on 18 F-FDG PET for glioma diagnosis: a systematic review and meta-analysis.

Background: Machine learning (ML) applied to radiomics has revolutionized neuro-oncological imaging, yet the diagnostic performance of ML models based specifically on ^18F-FDG PET features in glioma remains poorly characterized.

Objective: To systematically evaluate and quantitatively synthesize the diagnostic accuracy of ML models trained on ^18F-FDG PET radiomics for glioma classification.

Methods: We conducted a PRISMA-compliant systematic review and meta-analysis registered on OSF ( https://doi.

Validation of the Persian Triage Decision-Making Inventory (TDMI): a cross-cultural adaptation study.

Background: Effective triage decision-making is crucial in emergency care, requiring healthcare personnel to possess strong cognitive abilities, experience, and intuition. The Triage Decision Making Inventory (TDMI) is a standardized tool designed to assess these competencies. However, cultural and linguistic differences necessitate the adaptation and validation of such tools for specific populations.

Evaluation of the protective effect of Benfotiamine against neurotoxic effects, depression and oxidative stress induced by noise exposure.

According to reports on the significant impact of oxidative stress caused by noise exposure on the development of cognitive, behavioral and functional impairments in the brain, as well as the beneficial effect of antioxidants in mitigating neurotoxicity and behavioral issues, this study aimed to investigate the outcomes of noise exposure and evaluate the protective effect of Benfotiamine against the neurotoxic effects, depression and oxidative stress caused by noise exposure. In this study, adult male BALB/c mice were randomly divided into groups of 10 animals each: Control (C), Noise exposure (N), Noise exposure with 100 mg/kg of Benfotiamine (NB1), noise exposure with 200 mg/kg of Benfotiamine (NB2) and noise exposure with N-acetylcysteine (NN). Depressive-like behavior was assessed using the Tail Suspension Test (TST), Forced Swimming Test (FST) and Sucrose Preference Test (SPT).

Post-COVID-19 depression prevalence in Iranian nurses: a systematic review and meta-analysis.

Objectives: This systematic review and meta-analysis aimed to assess the pooled prevalence of post-COVID-19 depression among Iranian nurses, identify at-risk groups and provide practical recommendations for intervention.

Design: In adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a systematic review and meta-analysis, encompassing studies published from 2019 to 2024. Comprehensive searches were performed across international and Iranian databases.

Accuracy and Reproducibility of Semidigital Versus Fully Digital Cephalometric Tracings Using a New Computer Program Versus Conventional Methods (Gold Standards): A Preliminary Study.

Cephalometric tracing can be done either conventionally or using computers. Digital dentistry and digital orthodontics have considerably facilitated procedures. Still, their diagnostic accuracy needs assessment.

A Young Man With Primary Pulmonary Myxoma.

Primary pulmonary myxoma is a rare tumor and is usually diagnosed incidentally in clinically asymptomatic patients as a well-defined lung mass without metastasizing. It should also be considered that diagnostic methods such as bronchoscopy or transthoracic aspiration may be nondiagnostic. Thus, tumor resection is essential for diagnosis and treatment.