A study of demographic and clinical characteristics of consumers of non-steroidal anti-inflammatory drugs: a large population-based study utilizing enrollment phase data from the tabari cohort.

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for managing pain and inflammatory conditions. However, their usage patterns and associated risk factors in the general population remain insufficiently understood, particularly in the Iranian context. This study aims to explore the epidemiological and clinical factors associated with NSAID consumption in a population-based cohort.

Depression, anxiety, and stress in breast cancer patients: prevalence, associated risk factors, and clinical correlates.

Overall, the prevalence and determinants of various forms of psychological distress such as depression and anxiety in breast cancer (BC) patients exhibit conflicting results, with some factors underexplored. The present study aimed to assess the prevalence and determinants of depression, anxiety, and stress among BC patients. This cross-sectional study assessed depression, anxiety, and stress in BC patients in Mazandaran, Iran, using the DASS-21 questionnaire, which showed high reliability (Cronbach's alpha: 0.

Comparing Vitamin D Level Between Patients with Psoriasis and Healthy Individuals: A Systematic Review and Meta-Analysis.

Background: Psoriasis is nowadays regarded as a systemic inflammatory disorder. Among the topicals, vitamin D derivates are often applied on the skin for their anti-inflammatory and immune-modulatory properties. Vitamin D serum levels in psoriasis (PsO) patients are still debated and an eventual depletion may offer the rational to integrate anti-psoriatic therapies with oral vitamin D.

Profile of Cigarette and Drug Use Status in Population of Tabari Cohort Study.

Background: The study of the smoking and drug use profile of the Tabari cohort enrolment phase, the outcomes of which will be evaluated in the coming years, has proper comprehensiveness. Therefore, the present study aimed to determine the cigarette and drug use status in the population of the Tabari cohort study (TCS).

Methods: In this study, the profile of cigarette and drug use in the TCS was evaluated.

Association between blood pressure and parameters related to sleep disorders in Tabari cohort population.

Background: Insomnia and other sleep disorders can cause an increase in blood pressure, thereby resulting in premature death. Regarding this, the present study was conducted to investigate the relationship between hypertension and parameters related to sleep disorders in Tabari cohort population.

Methods: In this cross-sectional study, the data from the enrollment phase of the Tabari cohort study were adopted.

An overview of possible solutions putting an end to the COVID-19 pandemic.

In early 2020, a novel coronavirus, SARS-CoV2, started to spread throughout the world. The World Health Organization (WHO) declared the coronavirus disease 2019 (COVID-19) as a pandemic on March 5, 2020. This 2020's pandemic has to date caused about 200,000 deaths and is still affecting the lives of people worldwide.

Helicobacter pylori Infection and Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.

Since numerous studies have stated that there may be a relationship between Helicobacter pylori infection and nonalcoholic fatty liver disease, and because of the high prevalence of both conditions worldwide, this study investigated the risk of non-alcoholic fatty liver disease in patients infected with H. pylori. Following a systematic review of PubMed, Scopus, Web of Science and Embase, and a search in Google Scholar using MeSH terms such as H.

Atorvastatin therapy in COVID-19 adult inpatients: A double-blind, randomized controlled trial.

Introduction: Efficacious therapies are urgently required to tackle the coronavirus disease 2019 (COVID-19). This trial aims to evaluate the effects of atorvastatin in comparison with standard care for adults hospitalized with COVID-19.

Methods: We conducted a randomized controlled clinical trial on adults hospitalized with COVID-19.

The role of vitamin D in the age of COVID-19: A systematic review and meta-analysis.

Background: Evidence recommends that vitamin D might be a crucial supportive agent for the immune system, mainly in cytokine response regulation against COVID-19. Hence, we carried out a systematic review and meta-analysis in order to maximise the use of everything that exists about the role of vitamin D in the COVID-19.

Methods: A systematic search was performed in PubMed, Scopus, Embase and Web of Science up to December 18, 2020.

Association between liver enzymes and metabolic syndrome: results of the enrollment phase of Tabari cohort.

Background: The association between liver enzymes and metabolic syndrome (MetS) has been evaluated in several studies with different results. The purpose of this study is to determine the association between the serum levels of these liver enzymes and MetS in Tabari cohort population.

Method: In this case-control study, data collected from the enrolment phase of the Tabari cohort population have been used.

Corticosteroids in idiopathic granulomatous mastitis: a systematic review and meta-analysis.

Idiopathic granulomatous mastitis (IGM) is an inflammatory disease of the breasts with an unknown etiology. Corticosteroids are one the primary options for treating this disease, but the results of previous studies concerning their efficacy have been controversial. We, therefore, decided to assess the effectiveness of corticosteroids on IGM using a systematic review and meta-analysis.

The Role of Hydroxychloroquine in COVID-19: A Systematic Review and Meta-Analysis.

Objective: A systematic review and meta-analysis was carried out to examine the role of hydroxychloroquine (HCQ) in the treatment of COVID-19.

Methods: We performed a systematic search in PubMed, Scopus, Embase, CochraneLibrary, Web of Science, Google Scholar, and medRxiv pre-print databases using available MeSH terms for COVID-19 and hydroxychloroquine. Data from all studies that focused on the effectiveness of HCQ with or without the addition of azithromycin (AZM) in confirmed COVID-19 patients, which were published up to 12 September 2020, were collated for analysis using CMA v.

Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis.

Background: High rate of cardiovascular disease (CVD) have been reported among patients with novel coronavirus disease (COVID-19). Meanwhile there were controversies among different studies about CVD burden in COVID-19 patients. Hence, we aimed to study CVD burden among COVID-19 patients, using a systematic review and meta-analysis.

Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: Potential therapeutic targeting.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta coronavirus that uses the human angiotensin-converting enzyme 2 (ACE2) receptor as a point of entry. The present review discusses the origin and structure of the virus and its mechanism of cell entry followed by the therapeutic potentials of strategies directed towards SARS-CoV2-ACE2 binding, the renin-angiotensin system, and the kinin-kallikrein system. SARS-CoV2-ACE2 binding-directed approaches mainly consist of targeting receptor binding domain, ACE2 blockers, soluble ACE2, and host protease inhibitors.

Levels of Blood Biomarkers among Patients with Myocardial Infarction in Comparison to Control Group.

Background: Myocardial infarction (MI) as a term for a heart attack happens due to reduced blood flow to heart myocardium and lack of oxygen supply caused by plaques in the interior walls of coronary arteries. With respect to the importance of MI etiology, we aimed to study the relationship of MI and blood examination variables.

Methods: This study was conducted in Mazandaran Heart Center as a hospital-based case-control Comprising 894 participants including 465 cases and 429 controls, individually matched by sex and age.