Publications by authors named "Ziaeddin Oladi"
Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising at an alarming rate, making it a major global public health problem. The main pathophysiology of NAFLD is elevated de novo lipogenesis (DNL) in hepatocytes which leads to lipid accumulation. Because of their function in controlling DNL, sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) have been considered viable therapy targets for reduce lipid accumulation.
View Article and Find Full Text PDFKey Clinical Message: Here we present a case of a 4-year-old girl who suffered from vulvovaginitis caused by . All members of her family were also infected by this helminth. Treatment with mebendazole was administered to all family members and it was found that the entire family had been cured.
View Article and Find Full Text PDFSerum calprotectin can indicate current and future severity of COVID-19.
J Clin Lab Anal
January 2023
Article Synopsis
- The study investigated the role of calprotectin and other inflammatory markers in determining the severity and outcomes of COVID-19 among patients.
- Elevated levels of calprotectin were found in COVID-19 patients compared to controls, correlating with disease severity and respiratory issues.
- Calprotectin shows promise as a reliable prognostic tool for predicting poor clinical outcomes in COVID-19 patients, exhibiting strong predictive capability compared to other biomarkers.
Atorvastatin therapy in COVID-19 adult inpatients: A double-blind, randomized controlled trial.
Int J Cardiol Heart Vasc
October 2021
Introduction: Efficacious therapies are urgently required to tackle the coronavirus disease 2019 (COVID-19). This trial aims to evaluate the effects of atorvastatin in comparison with standard care for adults hospitalized with COVID-19.
Methods: We conducted a randomized controlled clinical trial on adults hospitalized with COVID-19.
Purpose: Identification of critical genes which play pivotal roles in controlling tumor growth and survival will establish the basis for developing therapeutic targets. In this study, we focused on frequencies of EGFR, ErbB2 and MET gene amplification in gastric cancer patients to develop personalized medicine to improve the treatment.
Method: EGFR, ErbB2 and MET gene amplification, and mRNA expression were analyzed by the quantitative Real-Time PCR in paraffin-embedded samples from 115 patients with gastric cancer.