The ameliorative effects of L-arginine on testicular and genotoxic toxicity induced by chronic exposure to cadmium chloride in male murine models.

Cadmium (Cd) is a toxic heavy metal known to cause DNA damage, genetic alterations, and reproductive issues in males through free radical production. This study investigates L-arginine, an amino acid with antioxidant and metal-chelating properties, in mitigating Cd-induced genetic and reproductive toxicity in male mice. Thirty-six male mice were divided into six groups: a control group, a Cd group (2 mg/kg), three groups receiving Cd (2 mg/kg) combined with L-arginine (50, 100, 200 mg/kg), and a positive control group receiving vitamin C (500 mg/kg) with Cd.