Metformin effects on respiratory and metabolic outcomes in asthma and metabolic syndrome: a double-blind, randomized, placebo-controlled clinical trial.

Introduction: Metabolic syndrome (MetS) could be associated with worsened asthma control and more severe and frequent asthma attacks. Metformin has been suggested as a potential treatment for MetS, which could decrease airway reactivity and lead to improved asthma control and reduced emergency department (ED) visits. However, the existing data have predominantly focused on diabetic patients only.

Pelvic splenosis implanted in Douglas pouch mimics pseudo-endometriosis symptoms: a case report study.

Introduction And Importance: Pelvic splenosis is characterized by the autotransplantation of spleen fragments following tissue rupture. Since the fragments are mostly implanted into the Douglas pouch, endometriosis-like symptoms are developed, clinically. Thus, this case report demonstrated a successful surgical procedure for pelvic splenosis management.

Comparing the results of knee osteoarthritis treatment with intra-articular injection of steroid (methylprednisolone) and hyaluronic acid.

Background: Treatments for osteoarthritis, including steroids and nonsteroidal anti-inflammatory drugs, are not very satisfactory. Therefore, we decided to compare the therapeutic results of intra-articular injection of hyaluronic acid and methylprednisolone.

Methods: In this single-blind clinical trial, 132 patients with osteoarthritis of the knee were randomly assigned to two treatment groups; hyaluronic acid and methylprednisolone.

Effectiveness of sumac seed capsules prepared from an aqueous extract in diabetic patients: A double-blind clinical trial study.

Background: Type 2 diabetes or non-insulin-dependent diabetes is one of the most common types of diabetes. The existing treatments for type 2 diabetes have not been able to completely cure this disease in affected cases. Sumac showed antioxidants, reducing blood sugar and serum cholesterol levels.

The Impact of Cholecystectomy on Colorectal Cancer Risk: A Comprehensive Review on Risk Factors and the Association.

Purpose Of Review: This review examines the debated association between cholecystectomy and colorectal cancer risk. The goal is to evaluate biological mechanisms, epidemiological evidence, and related risk factors to better understand this potential association.

Recent Findings: Cholecystectomy may increase CRC risk through altered bile acid metabolism and gut microbiota changes, particularly in the right colon.

Exploring the oxidative and inflammatory markers landscape in Buerger's disease: A comparative analysis.

Background: Buerger's disease (BD) is characterized by inflammation and blood clotting in smaller to medium-sized blood vessels of the extremities. This study aimed to explore oxidative stress and antioxidant capacity in BD compared to healthy smokers.

Materials And Methods: A case-control study was conducted, involving 10 BD patients and 10 healthy smokers as controls, with average ages of 39.

Temporomandibular joint disorder related to cancer metastasis: A review on reported cases in the literature.

Introduction: Metastasis to the temporomandibular joint is an uncommon clinical entity that often mimics benign temporomandibular disorders, leading to diagnostic challenges. This systematic review aimed to consolidate the existing literature on temporomandibular joint metastasis to delineate its clinical and demographic characteristics, diagnostic pitfalls, and treatment approaches.

Methods: A comprehensive search was conducted across PubMed/MEDLINE, Scopus, and Embase electronic databases.

Excruciating pain, enduring suffering, and searing burns: The culture of care in burn units of hospital in Iran.

Burn injuries are among the significant threats to population health, with distinct characteristics, and caring for these injuries is of paramount importance. Along with the painful sensations, burns bring about profound grief and enduring suffering that encompass not only patients but also their families and communities. This ethnographic study, conducted in 2021-2022 focused on the pain and suffering resulting from burns and their management in the Iranian context.

Exploring dissolved organic matter diversity and water quality in the Tajan River using PARAFAC techniques.

Rivers carry dissolved organic matter (DOM), which influences nutrient cycling, pollutant transport, and the distribution of microbial communities within aquatic ecosystems. This research investigates dissolved organic carbon (DOC) diversity and its impact on water quality within the Tajan River watershed. Sampling was conducted from March 2023 to February 2024 at ten stations, where key parameters including temperature, dissolved oxygen (DO), turbidity, electrical conductivity (EC), chemical oxygen demand (COD), DOC, total phosphorus (TP), total nitrogen (TN), and chlorophyll-a were measured using standard methods.

Persian version of nursing students' learning behavior questionnaire: cross-cultural adaptation and psychometric testing.

Background: Nursing students' learning behavior assessment is vital for educational quality and clinical performance. While existing questionnaires often focus on specific aspects, a comprehensive instrument is needed to evaluate multiple learning behavior dimensions.

Objectives: To translate and evaluate the psychometric properties of the Nursing Students' Learning Behavior Questionnaire (NSLBQ) in Persian.

Targeting the HGF/MET axis in cancer: therapeutic promise for natural compounds.

The hepatocyte growth factor (HGF)/MET signaling pathway plays a pivotal role in cancer progression, metastasis, and therapeutic resistance, making it an attractive target for anticancer therapies. HGF, a multifunctional cytokine, binds to the MET receptor, triggering downstream pathways such as PI3K/AKT, MAPK/ERK, and STAT3, which regulate cell proliferation, survival, and epithelial-mesenchymal transition (EMT). Dysregulation of this pathway-through mutations, amplifications, or overexpression-contributes to tumorigenesis, drug resistance, and poor prognosis in various cancers, including lung, breast, gastric, and hepatocellular carcinomas.

Solitary infantile myofibromatosis presenting as multiple subcutaneous lesions: a case report.

Background: Infantile myofibromatosis is a rare benign mesenchymal disorder characterized by the proliferation of myofibroblasts, representing the most common fibrous tumor of infancy and early childhood. Solitary infantile myofibromatosis is the most common variant, typically presenting as a firm, painless dermal or subcutaneous mass. This case is notable for the early prenatal detection of multiple subcutaneous lesions, initially presumed to be lymphangiomas, but later confirmed as infantile myofibromatosis postnatally.

The Current Status of Medical Parasitology in Iran: Developing a Roadmap, Structural Mapping, and Proposed Scenarios for the Future of This Field.

Background: We aimed to review and analyze the status of Medical Parasitology course including current problems and challenges on human resources, infrastructure, research capacities, educational and investigative priorities in Iran, and to develop a roadmap and future development in this field.

Methods: A questionnaire was prepared to obtain information on Medical Parasitology departments in the country followed by field visits in many cases to collect data on the status of the faculty members, laboratory experts, physical spaces, laboratory equipment, microscopic slides, training Parasitology techniques, research projects and theses, published articles and books, access to Parasitology journals, books and e-books during 2022-2023. A roadmap and future development for Medical Parasitology in Iran and the formulation of a desirable status concerning short term to long-term goals was compiled.

Clinical Challenges and Predictive Risk Factors for Outcomes in COVID-19-Associated Mucormycosis.

Background & Objective: Mucormycosis has emerged as a severe complication in COVID-19 patients, particularly among those with uncontrolled diabetes and those receiving corticosteroid therapy. The infection's tendency to spread from the sinuses to the orbit and central nervous system (CNS) significantly increases morbidity and mortality. This study aimed to identify clinical risk factors and outcomes associated with disease severity and mortality in COVID-19-associated mucormycosis (CAM), with a focus on disease progression to orbital and CNS involvement.

Understanding frailty in aging: a multidimensional perspective from Northern Iran.

Background: The global aging population is increasing rapidly, positioning frailty as a significant health concern among older adults. Despite its significance, data on the prevalence and determinants of frailty among community-dwelling older adults in Iran remain limited. This study aimed to assess the prevalence of frailty and identify its associated factors among older adults attending primary healthcare centers in Sari, Iran, using the Tilburg Frailty Indicator (TFI).

Coenzyme Q10 ameliorates anxiety and depression‑like behavior associated with chronic opioid use and increases GDNF expression in the hippocampus of morphine‑dependent rats.

Opioid dependence is strongly associated with moderate to severe depression and anxiety. The primary objective of this investigation was to determine whether coenzyme Q10 (CoQ10) has the capacity to increase the level of glial cell line‑derived neurotrophic factor (GDNF), with the aim of ameliorating anxiety‑ and depression‑like behaviors in morphine (MOP)‑dependent rats. In this study, 40 male Wistar rats were randomly divided into five experimental groups: Oil group, MOP+Oil group, MOP+Q10‑100 group, MOP+Q10‑200 group, and MOP+Q10‑400 group.

Utilization of Rehabilitation Services by Disabled People under the Iranian Health Insurance Organization.

Background: People with disabilities have greater unmet needs and need health care. These people are acknowledged as a global development priority. This study aimed to investigate the utilization of rehabilitation services by people with disabilities covered by the Iran Health Insurance Organization.

Psychometric evaluation of the Farsi version of the electroconvulsive therapy related anxiety questionnaire.

Background: This study aimed to assess the psychometric properties of the Farsi version of the Electroconvulsive Therapy-Related Anxiety Questionnaire (ERAQ).

Methods: This methodological study was conducted among patients undergoing or with a history of Electro Convulsive Therapy (ECT) in Mashhad, Iran, during 2024-2025. Data were collected using a demographic profile form and the ERAQ.

Comparison of the Effect of Adding Dexmedetomidine Versus Dexamethasone to Bupivacaine in Transverse Abdominis Plane Block on Postoperative Pain Intensity in Patients Undergoing Laparoscopic Cholecystectomy.

Background: Laparoscopic cholecystectomy, compared to open surgery, offers advantages such as lower pain levels and shorter hospitalization. However, postoperative pain remains a common challenge. Inadequate pain control may lead to discomfort, reduced mobility, and prolonged hospitalization.

Brain Oscillations in Bipolar Disorder: Insights from Quantitative EEG Studies.

IntroductionQuantitative electroencephalography (QEEG) is a neurophysiological tool that analyzes brain oscillations across frequency bands, providing insights into psychiatric conditions like bipolar disorder (BD). This disorder, marked by mood fluctuations, poses diagnostic and treatment challenges, highlighting the need for reliable biomarkers.ObjectiveThis systematic review aims to evaluate QEEG changes in BD patients, investigate its diagnostic and therapeutic potential, and differentiate BD from major depressive disorder (MDD) and schizophrenia.

Predicting postpartum female sexual interest/arousal disorder via adiponectin and biopsychosocial factors: a cohort-based decision tree study.

After childbirth, women experience significant psychological, physiological, and hormonal changes. To better diagnose individuals at risk of postpartum complications, predictive models utilizing data mining and machine learning techniques can be instrumental. The C4.

THE RELATIONSHIP BETWEEN ENTAMOEBA GINGIVALIS AND TRICHOMONAS TENAX WITH PERIODONTITIS AND GINGIVITIS: A SYSTEMATIC REVIEW, META-ANALYSIS, AND META-REGRESSION.

Introduction: Despite numerous studies investigating the link between Entamoeba gingivalis and Trichomonas tenax and periodontal diseases, findings remain inconclusive. To resolve this inconsistency, we conducted a meta-analysis to assess the association between E. gingivalis and T.

Unanticipated Pathological Laughter Following Atomoxetine Administration in a Child With Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder.

Introduction: Atomoxetine, a selective norepinephrine reuptake inhibitor (NRI), is commonly prescribed for attention-deficit/hyperactivity disorder (ADHD) and has shown effectiveness in children with autism spectrum disorder (ASD). Although mood disturbances and psychiatric symptoms are recognized side effects, pathological laughter has not been previously reported.

Case Presentation: We present the case of a 6-year-old boy diagnosed with both ASD and ADHD who developed sudden, uncontrollable episodes of pathological laughter after beginning low-dose atomoxetine (5 mg/day, ~0.