Publications by authors named "Amin Golabpour"

After childbirth, women experience significant psychological, physiological, and hormonal changes. To better diagnose individuals at risk of postpartum complications, predictive models utilizing data mining and machine learning techniques can be instrumental. The C4.

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  • - The study focuses on the application of machine learning (ML) in improving nanoliposomal formulations for targeted drug delivery, exploring how ML can enhance the preparation and characterization of these lipid-based systems.
  • - It reviews different ML techniques, including ensemble learning and neural networks, while discussing the importance of data handling, feature extraction, and the significance of supervised learning models for achieving better liposomal formulations.
  • - The review highlights the effectiveness of ML in optimizing key formulation parameters and suggests a structured framework to incorporate ML as a decision support system in the development of liposomal therapies.
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Detecting clinical keratoconus (KCN) poses a challenging and time-consuming task. During the diagnostic process, ophthalmologists are required to review demographic and clinical ophthalmic examinations in order to make an accurate diagnosis. This study aims to develop and evaluate the accuracy of deep convolutional neural network (CNN) models for the detection of keratoconus (KCN) using corneal topographic maps.

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Liposome nanoparticles have emerged as promising drug delivery systems due to their unique properties. Assessing particle size and polydispersity index (PDI) is critical for evaluating the quality of these liposomal nanoparticles. However, optimizing these parameters in a laboratory setting is both costly and time-consuming.

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Background: Curcumin faces challenges in clinical applications due to its low bioavailability and poor water solubility. Liposomes have emerged as a promising delivery system for curcumin. This study aims to apply ensemble learning, a machine learning technique, to determine the most effective experimental conditions for formulating stable curcumin-loaded liposomes with a high entrapment efficiency (EE).

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  • PTEN hamartoma tumor syndrome (PHTS) is a rare genetic disorder linked to mutations in the PTEN gene, often resulting in multiple gastrointestinal polyps and a family history of certain cancers.
  • A case study of a 39-year-old Iranian woman revealed over 20 rectosigmoid polyps, leading to a genetic evaluation that confirmed PHTS despite a lack of typical physical symptoms.
  • A literature review identified 43 PHTS cases, highlighting common signs such as breast, thyroid, and endometrial cancers, as well as the presence of specific skin lesions, emphasizing the need for thorough investigation in patients with multiple polyps.
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  • The study investigates the rising incidence of colorectal cancer in patients under 50 by evaluating demographic and clinical characteristics in northeast Iran.
  • It comprised a three-year retrospective analysis of 562 CRC cases, focusing on differences between early-onset (≤50 years) and late-onset (>50 years) cancer, including genetic risk factors like Lynch syndrome.
  • Results indicated higher early-onset CRC rates in females (56%) compared to males (44%), with mean ages of 40.3 years for early-onset and 65.1 years for late-onset CRC, but the anatomical tumor location differences weren't statistically significant.
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Background: With the growing rate of cesarean sections, rising morbidity and mortality thereafter is an important health issue. Predictive models can identify individuals with a higher probability of cesarean section, and help them make better decisions. This study aimed to investigate the biopsychosocial factors associated with the method of childbirth and designed a predictive model using the decision tree C4.

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Missing data occurs in all research, especially in medical studies. Missing data is the situation in which a part of research data has not been reported. This will result in the incompatibility of the sample and the population and misguided conclusions.

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Background: The high prevalence of COVID-19 has made it a new pandemic. Predicting both its prevalence and incidence throughout the world is crucial to help health professionals make key decisions. In this study, we aim to predict the incidence of COVID-19 within a two-week period to better manage the disease.

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Background: Response time to cardiovascular emergency medical requests is an important indicator in reducing cardiovascular disease (CVD) -related mortality. This study aimed to visualize the spatial-time distribution of response time, scene time, and call-to-hospital time of these emergency requests. We also identified patterns of clusters of CVD-related calls.

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Background And Aim: Gastric cancer is one of the most prevalent cancers in the world. Characterized by poor prognosis, it is a frequent cause of cancer in Iran. The aim of the study was to design a predictive model of survival time for patients suffering from gastric cancer.

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Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division.

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Background: Missing values in data are found in a large number of studies in the field of medical sciences, especially longitudinal ones, in which repeated measurements are taken from each person during the study. In this regard, several statistical endeavors have been performed on the concepts, issues, and theoretical methods during the past few decades.

Methods: Herein, we focused on the missing data related to patients excluded from longitudinal studies.

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  • * In a study of 43 HTLV-1-infected individuals, ATLL patients had significantly higher expression levels of these oncogenes and higher proviral load (PVL) compared to asymptomatic carriers.
  • * A negative correlation was found between PVL and survival rates in ATLL patients, suggesting that tracking these viral markers could help predict patient outcomes and inform treatment strategies.
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