Nanomedicine Solutions for Inhibiting Anastasis and Inducing Apoptosis to Mitigate Relapse in Treatment-Resistant Cancers.

Cancer is a leading cause of global mortality, significantly impacted by treatment resistance and the toxicity of conventional therapies like chemotherapy and radiation. Recent studies show that anastasis-the recovery of cells from near-death states-as a key mechanism promoting cancer relapse and apoptosis resistance. During anastasis, stress-induced caspase activation allows cancer cells to survive, increase chemoresistance, and enhance metastatic potential.

Language dysfunction as a primary feature of cognitive decline in neurological populations.

Cognitive decline is a common feature of neurologic conditions, with language functions often affected. Word finding difficulties are commonly reported to neurologists in clinic. Receptive language dysfunction (i.

Synergistic modulation of p53-HMGB1 complex and its binding to DNA: The role of nanotechnology in overcoming cancer drug resistance; A literature review and in-silico analysis.

The interplay between the tumor suppressor protein p53 and high mobility group box 1 (HMGB1) is critical in cancer therapy, influencing responses to chemotherapy, radiotherapy, and immunotherapy. Despite the significance of these interactions, the relationship between these factors in treatment remains inadequately explored, underscoring the urgent need for further investigation. Hence, this review elucidates the mechanisms by which p53 and HMGB1 modulate cellular stress responses, apoptosis, and autophagy, highlighting their roles in multidrug resistance (MDR).

Topical erythropoietin in the management of scleral necrosis: a narrative review.

Scleral necrosis is a rare but severe complication caused by various etiologies. The main therapeutic approach is topical and systemic medical treatment. Surgical interventions may be indicated in unresponsive cases.

Deep Learning-Driven Proteomics Analysis for Gene Annotation in the Renin-Angiotensin System.

The renin-angiotensin system (RAS) is central to cardiovascular diseases such as hypertension and cardiomyopathy, yet the functions of many RAS genes remain unclear. This study developed a multi-label deep learning model to systematically annotate RAS gene functions and elucidate their roles in biological pathways. A total of 39,463 RAS-related publications from PubMed and PMC were processed into text format.

Impact of non-medical treatments of endometrioma on pregnancy outcome: a systematic review and meta-analysis.

This meta-analysis assesses the impact of non-medical endometrioma treatments on pregnancy rates in infertile women with endometriosis. Based on a search of PubMed, Scopus, EMBASE and Web of Science, 24 prospective English-language studies (2000-2022, participant age 15-45 years, n = 2458) were identified that reported treatment and pregnancy rates based on the 2020 PRISMA checklist. Random effects modelling minimized bias; heterogeneity (I²) and publication bias were assessed using MedCalc.

Forensic Entomology in Criminal Investigations: Advances in Insect-Mediated Postmortem Interval Estimation, Species Identification, and Environmental Influences.

Forensic entomology is a crucial discipline in forensic investigations, primarily used for postmortem interval (PMI) estimation, species identification, and crime scene reconstruction. Recent advancements in molecular techniques, computational models, and climate-adaptive forensic entomology have enhanced the field's forensic applications. However, challenges related to methodological standardization, environmental variability, and legal admissibility persist.

Artificial Intelligence Challenges in the Healthcare Industry: A Systematic Review of Recent Evidence.

While AI is essential to the development of electronic health, it has challenges that, if resolved, might improve the standard of healthcare services. The purpose of this study is to classify and identify these issues in the healthcare field. The study utilised a systematic review approach, drawing data from the Scopus, Web of Science, and PubMed databases.

Sildenafil blunts cholestasis-associated cholemic nephropathy in a rat model of bile duct ligation.

Aim Of The Study: Cholestasis is characterized by impaired bile flow from the liver to the small intestine. Beyond liver damage, cholestasis significantly affects other organs, particularly the kidneys, causing a condition known as cholemic nephropathy (CN). Sildenafil is a phosphodiesterase type 5 (PDE5) enzyme inhibitor with a wide range of pharmacological effects.

Skin-Colored Papules on the Face and Chest of a Female Patient.

Scleromyxedema is an unpredictable but progressive disease and can be lethal due to systemic involvement if not diagnosed timely. Hence, we require a keen observational clinical eye to diagnose the condition from its differentials, along with further research into treatment modalities to treat this condition.

An Infrared Non-Invasive System for Measuring Blood Glucose: A Primary Study using Serum Samples.

Background: Diabetes is a global concern, with an estimated 2 million individuals expected to be affected by the condition by 2024. Non-invasive glucose monitoring devices can greatly enhance patient care and management.

Objective: This study aimed to develop an instrument capable of non-invasively measuring blood glucose levels using an infrared transmitter and receiver, with data processing performed by a dedicated processor.

Utilizing Artificial Intelligence for the Diagnosis, Assessment, and Management of Chronic Pain.

Chronic pain is a prevalent condition and the leading cause of work absenteeism worldwide. This condition involves persistent pain lasting more than three months, significantly impacting the quality of life and social interactions of patients. While the causes of chronic pain can often remain unknown, no definitive cure exists for the various known causes.

An in Vitro Study on Anticancer Efficacy of Capecitabine- and Vorinostat-incorporated Self-nanoemulsions.

Background: Cancer has emerged as a critical global health concern due to its widespread prevalence and impact on individuals, families, communities, and healthcare systems worldwide.

Objective: We investigated the anticancer effectiveness of capecitabine (CAP) and vorinostat (VOR) when incorporated into self-nanoemulsifying drug delivery systems (SNEDDSs).

Material And Methods: In this experimental study, the SNEDDSs were formulated using polyethylene glycol 600 (PEG 600), castor oil and Tween 80.

NUTM2A-AS1 as a potential key regulator in cancer: unraveling its ceRNA networks and impact on tumor biology.

NUTM2A-AS1 is an emerging long noncoding RNA (lncRNA) that has garnered significant attention due to its multifaceted roles in cancer biology. As a member of the ceRNA network, NUTM2A-AS1 modulates gene expression by sequestering microRNAs, thereby influencing key oncogenic pathways. This review aims to provide a comprehensive overview of the current understanding of NUTM2A-AS1 in the development, progression, and metastasis of various cancers, including gastric cancer, hepatocellular carcinoma, neuroblastoma, colorectal cancer, glioma, lung adenocarcinoma, prostate cancer, and renal cell carcinoma.

The association between periostin and tumor microenvironment: a promising cancer prognostic biomarker and therapeutic target to combat tumor progression and chemoresistance.

Over the past few decades, cancer research has increasingly focused on tumor microenvironment (TME). The TME contains diverse cellular components and secreted factors, including leukocytes, endothelial cells, cancer-associated fibroblasts, and other non-cancerous cells and extracellular matrix proteins. The interactions between tumor cells and microenvironment elements are complex and unpredictable.

Synergistic Effects of an Eight-Week Resistance Training and Probiotic Supplementation on Bone Metabolism in Ovariectomized Rats.

Aging is one of the most influential factors in bone metabolism, leading to a universal decline in bone density in both men and women. This study aimed to investigate the effects of eight weeks of resistance training and probiotic supplementation on bone metabolism in ovariectomized rats. A total of 48 female Sprague-Dawley rats were randomly assigned to six groups: control, sham, ovariectomy, ovariectomy+probiotic supplementation, ovariectomy+resistance training, and ovariectomy+resistance training+probiotic supplementation.

Oral contraceptive use and its sociocultural determinants in Iranian women: a secondary cross-sectional analysis from the PARS cohort study.

Background: This study addresses a gap in global research by exploring sociocultural factors and health outcomes related to oral contraceptive pill (OCP) use among middle-aged Iranian women, where non-prescription access is common. It aims to identify determinants of OCP use and its association with chronic diseases in this demographic.

Methods: This study was a secondary cross-sectional analysis which was conducted using baseline data from the Pars Cohort Study, launched in 2012 and included a sample of 4,034 married middle-aged women aged 45–64 years residing in Fars Province, Iran.

A systematic review on predictors of postreperfusion hyperkalemia during liver transplantation.

Background: Liver transplantation (LT) is a well-known efficacious treatment for life-threatening liver diseases. This complicated surgery is significantly associated with morbidity and mortality. Hyperkalemia (a condition where the blood potassium level is ≥ 5 mEq/L) is a serious complication that occurs at all times during liver transplantation, but it happens more frequently within 5 min after reperfusion.

Comparison of the incidence of reperfusion syndrome and outcomes of liver transplantation among pediatric recipients of partial vs. whole graft: report of six-year retrospective study.

Background: Advancements in graft selection, surgical and anesthetic techniques have improved the outcomes of pediatric liver transplantation over the last few decades. In this study, we evaluate preoperative factors, the incidence of post-reperfusion syndrome, rejection, and survival among 523 pediatric patients who received whole vs. partial liver transplantation.

Guillain-Barré Syndrome and Related Neuropathies Post-Bariatric Surgery: A Systematic Review of Clinical Cases and Outcomes.

Bariatric surgery is a widely used treatment for morbid obesity, but it can lead to neurological complications, including Guillain-Barré Syndrome (GBS), a rare immune-mediated polyneuropathy. The mechanisms underlying post-bariatric GBS remain unclear, and no comprehensive review has evaluated its incidence, risk factors, and outcomes. This systematic review synthesizes available clinical data to assess the relationship between bariatric surgery and GBS, focusing on its presentation, diagnosis, and management.

Mortality risk factors in chest trauma patients in a level one trauma center in southern Iran.

Chest trauma is one of the most prevalent subgroups of trauma, accounting for 1 out of 4 deaths relating to trauma. Gaining insights into the trends of chest trauma is crucial in tackling its significant role in causing injuries and fatalities, particularly in low- and middle-income nations. Therefore, we aimed to investigate the prevalence of chest trauma, the types of injuries, mechanisms of injury, and predictors of mortality in the largest level one trauma center in southern Iran.

Carotenoids as neuroprotective agents in multiple sclerosis: Pathways, mechanisms, and clinical prospects.

Multiple sclerosis (MS) is a chronic autoimmune andneurodegenerative disorder affecting the central nervous system (CNS), characterized by demyelination and neuroinflammatory responses, oxidative stress, and immune dysregulation. The global incidence of MS is rising, demonstrating the necessity for new therapeutic agents against its complex pathophysiology. Carotenoids, naturally pigments with strong antioxidant, anti-inflammatory, immunomodulatory, and neuroprotective activities, have been recognized as promising candidates to target MS.

Continued Root Formation after a Compound root Fracture in an Immature Permanent Incisor: A Case Report with a 2-year follow-up.

While traumatic injuries in the young permanent dentition are frequent, root fractures are relatively rare, particularly in immature teeth. This study reports the case of a 7-year-old boy who fell off a bicycle. Radiographic examination showed an immature right upper central incisor with fractures in the middle and along the root in an oblique and horizontal direction.

A New Regression Model Based on Salivary Biomarkers, Chronological Age and Gender to Predict the Stage of Cervical Vertebral Maturation in Orthodontic Patients.

Background: In orthodontics, radiography-based methods are frequently used for the assessment of skeletal maturity. Concerning X-ray exposure hazard, a new objective and less invasive method is needed to identify the optimal orthodontic treatment timing.

Purpose: In this study, the pattern of salivary alkaline phosphatase and insulin-like growth factor-1 in the circumpubertal period was investigated.