Cancer is a leading cause of global mortality, significantly impacted by treatment resistance and the toxicity of conventional therapies like chemotherapy and radiation. Recent studies show that anastasis-the recovery of cells from near-death states-as a key mechanism promoting cancer relapse and apoptosis resistance. During anastasis, stress-induced caspase activation allows cancer cells to survive, increase chemoresistance, and enhance metastatic potential.
View Article and Find Full Text PDFInt J Biol Macromol
October 2024
Trinitroglycerin (TNG) with remarkable angiogenic, antibacterial, and antioxidative activity is a promising candidate to govern wound healing capacity. However, its clinical administration is limited due to associated complications and NO short half-life. In the current study, TNG-loaded chitosan nanogels (TNG-Ngs) were examined in-vitro and in-vivo to gain insight into their clinical application.
View Article and Find Full Text PDFAppl Biochem Biotechnol
January 2025
The development of biocompatible wound dressings containing therapeutic agents to accelerate wound healing is an interesting field of study in biomedical sciences. Polyvinyl alcohol (PVA) nanofibers were loaded with zinc oxide nanoparticles (ZnO NPs) and curcumin (Cur) through electrospinning. The dressings were characterized by SEM and XRD and FTIR.
View Article and Find Full Text PDFBackground: Acne is a common skin issue that typically occurs during adolescence. It causes long-lasting redness and swelling in the skin. An alternative approach to treating acne could involve using a cosmetic facial mask containing herbal ingredients such as Curcumin and Rosa Damascena extract for its antibacterial properties.
View Article and Find Full Text PDFSeveral studies have revealed that healthcare nanomaterials are widely used in numerous areas of dentistry, including prevention, diagnosis, treatment, and repair. Nanomaterials in dental cosmetics are utilized to enhance the efficacy of toothpaste and other mouthwashes. Nanoparticles are added to toothpastes for a variety of reasons, including dental decay prevention, remineralization, hypersensitivity reduction, brightening, and antibacterial qualities.
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