Publications by authors named "Haleh Siami"
Artificial Intelligence Challenges in the Healthcare Industry: A Systematic Review of Recent Evidence.
Healthc Technol Lett
September 2025
While AI is essential to the development of electronic health, it has challenges that, if resolved, might improve the standard of healthcare services. The purpose of this study is to classify and identify these issues in the healthcare field. The study utilised a systematic review approach, drawing data from the Scopus, Web of Science, and PubMed databases.
View Article and Find Full Text PDFPrevalence of COVID-19 in prison population: a meta-analysis of 35 studies.
Int J Prison Health (2024)
December 2024
Article Synopsis
- The study investigates the prevalence of COVID-19 among prisoners, highlighting the increased risk due to confined spaces and close contact in prisons.
- It analyzed English-language studies published from 2019 to July 2023, using various databases and statistical methods to determine prevalence rates, finding a pooled prevalence of around 20% to 25%.
- The study suggests that by implementing better planning in prison environments, the spread of COVID-19 among inmates could be significantly reduced.
Introduction: This study examines the efficacy and safety of three COVID-19 booster vaccines including mRNA-based vaccines (BNT162b2 (BioNTech/Pfizer) and/or mRNA-1273 (Moderna)), Non-Replicating Viral-Vector vaccines (ChAdOx1 nCoV-19 vaccine (AstraZeneca) and/or Ad26. COV2.S (Johnson & Johnson)), and Protein Subunit vaccine (SpikoGen) in immunosuppressed patients.
View Article and Find Full Text PDFRNA interference-based therapies for atherosclerosis: Recent advances and future prospects.
Prog Mol Biol Transl Sci
March 2024
Article Synopsis
- * RNA-based therapies, especially using microRNAs and small interfering RNAs (siRNAs), have shown potential for treating various diseases, including cardiovascular disease (CVD).
- * Despite their promise, RNA therapies face challenges like poor binding, instability, delivery issues, immune responses, and unintended effects, which need to be addressed for effective medication development.
Objective: This article aimed to analyze upper endoscopic findings in the HIV patient population to elucidate the upper-gastrointestinal complications related to HIV infection. Gastrointestinal (GI) disorders in individuals living with HIV/AIDS exhibit diverse and often nonspecific manifestations, imposing substantial morbidity and mortality burdens. Endoscopic evaluation with biopsies is essential in the diagnosis and management of these conditions.
View Article and Find Full Text PDFArticle Synopsis
- * A systematic review of 23 cross-sectional studies involving over 16,315 truck drivers revealed a high seroprevalence of HIV, particularly noting a staggering 56% prevalence rate in South Africa.
- * Key risk factors identified include low awareness of HIV/AIDS, limited condom use, and lifestyle factors like time away from home, socio-economic status, drug/alcohol use, and sexual practices, suggesting that targeted interventions are essential for prevention.
The relationship of hip fracture and thyroid disorders: a systematic review.
Front Endocrinol (Lausanne)
October 2023
Article Synopsis
- Bone density regulation is influenced by thyroid hormones, which can lead to low bone density and increase the risk of hip fractures, particularly in people with thyroid disorders.
- A systematic review analyzed data from 19 studies, finding that women with differentiated thyroid cancer face a higher risk of hip fractures compared to those due to osteoporosis, and men with hyperthyroidism and subclinical hyperthyroidism are also at increased risk.
- While there is inconsistency in evidence regarding subclinical thyroid dysfunction and hip fractures, it appears that individuals with subclinical hyperthyroidism may have a heightened fracture risk.
Monkeypox infection outbreaks have been observed sporadically in Africa, usually as a result of interaction with wildlife reservoirs. The genomes of the new strain range in size from 184.7 to 198.
View Article and Find Full Text PDFGene and cell therapy approaches for familial hypercholesterolemia: An update.
Drug Discov Today
March 2023
Familial hypercholesterolemia (FH) is a common autosomal codominant hereditary illness marked by the heightened risk of early atherosclerotic cardiovascular disease and high blood levels of low-density lipoprotein cholesterol (LDL-C). FH patients can have homozygous or heterozygous variants. This condition has been linked to variations in the genes for the LDL receptor (LDLR), apolipoprotein B, proprotein convertase subtilisin/Kexin 9 (PCSK9), and LDLR adaptor protein 1.
View Article and Find Full Text PDFHypophosphatasia is a rare inherited disease defined by teeth and bone mineralization impairment leading to depletion of tissue non-specific alkaline phosphatase. We define a young woman diagnosed with hypophosphatasia (after several times alkaline phosphatase levels were low) was discovered following femoral fracture. A 30-year-old woman who presented for a history of early permanent teeth loss during the last 5 years and HPP-like symptoms in family history and bone radiograph verified bowing, deficient mineralization, and symmetrical subtrochanteric stress fractures of femurs was referred to our clinic for further management.
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