The Role of Pioglitazone as a Ferroptosis Inhibitor in Mitigating Radiation-Induced Damage in Testicular Tissue of Mice.

Introduction: Radiation targets cancer but risks causing infertility by damaging sensitive testes, especially spermatogonia. This study investigates IR-induced testicular damage and assesses PGZ's potential protective role as a ferroptosis inhibitor.

Material & Methods: In this study, Seventy-two BALB/c mice were randomly divided into eight groups: a control, PGZ (10, 20, and 30 mg/kg), IR (8 Gy), and IR+ PGZ (in three doses).

Assessing the Protective Effects of Pioglitazone on Radiation-Induced Cardiac Injury in an In Vivo Model: A Biochemical and Histopathological Investigation.

Introduction: RIHD is a significant complication in cancer radiotherapy, caused by oxidative stress and tissue damage. This study aimed to evaluate the protective effect of PGZ pretreatment against RIHD by assessing oxidative stress markers, enzyme levels, biochemical parameters, and cardiac tissue changes in a mouse model.

Materials & Methods: 72 BALB/c mice were randomly divided into eight groups: control, PGZ (10, 20, and 30 mg/kg), IR (8 Gy), and IR + PGZ (at three doses).

Targeting Wnt Pathways with Small Molecules as New Approach in Cardiovascular Disease.

The increasing incidences of morbidity and mortality associated with cardiovascular diseases represent significant difficulties for clinical treatment and have a major impact on patient health. Wnt signaling pathways are highly conserved and are well known for their regulatory roles in embryonic development, tissue regeneration, and adult tissue homeostasis. Wnt signaling is classified into two distinct pathways: canonical Wnt/β-catenin signaling and noncanonical pathways, including planar cell polarity and Wnt/Ca pathways.

Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance in Cancer Cells.

Radiotherapy (RT) is an integral part of treatment management in cancer patients. However, one of the limitations of this treatment method is the resistance of cancer cells to radiotherapy. These restrictions necessitate the introduction of modalities for the radiosensitization of cancer cells.