Residual disease in NPM1-mutated acute myeloid leukemia.

Acute myeloid leukemia (AML) represents a genetically heterogeneous malignancy, with mutations in the nucleophosmin-1 (NPM1) gene identified as the most prevalent and clinically significant molecular biomarkers. These mutations play a crucial pivotal role in the realms of diagnosis, prognosis, and therapeutic decision-making. Although an ideal measurable residual disease (MRD) test has yet to be developed, there is increasing acknowledgment of the significance of advanced molecular methodologies for monitoring MRD in NPM1-mutated (NPM1) AML.

Effects of Single-Session Treatment of Primary Teeth Under General Anesthesia Versus At-Office Multi-session Treatment on Permanent Molar Caries Status: Nonrandomized Clinical Trial.

Objectives: Effects of treatment under general anesthesia versus several sessions of at-office treatment on the transition of caries prevalence from primary to permanent dentitions have not been assessed. Moreover, other gaps exist in the literature.

Material And Methods: This 4-group non-randomized clinical trial was performed on 280 children 8-10 years old in 4 groups, including both negative and positive controls: children with a history of caries in primary teeth who were (1) treated routinely in office (n = 60) versus (2) under general anesthesia versus (n = 110) (3) similar children undergoing no treatment versus (positive control, n = 60) (4) children without a history of primary teeth caries (negative caries, n = 50).

Survival of Continuous Ambulatory Peritoneal Dialysis Patients Increases in the Early Years of Dialysis: Comparison of Parametric Frailty Survival Models.

Background: Previous studies on the survival of continuous ambulatory peritoneal dialysis (CAPD) patients have been done using the Cox model. This model requires establishing the basic assumption of proportional hazard (PH) and not establishing it leads to misleading inferences. Alternatively, if the time-to-event distribution is known, accelerated failure time models can be developed in such a way that no PH assumption is required.

Accuracy and Reproducibility of Semidigital Versus Fully Digital Cephalometric Tracings Using a New Computer Program Versus Conventional Methods (Gold Standards): A Preliminary Study.

Cephalometric tracing can be done either conventionally or using computers. Digital dentistry and digital orthodontics have considerably facilitated procedures. Still, their diagnostic accuracy needs assessment.

The significance of S100β and neuron-specific enolase (NSE) in postoperative cognitive dysfunction following cardiac surgery: a systematic review and meta-analysis.

Background: Postoperative cognitive dysfunction (POCD) significantly affects recovery, hospitalization duration, and quality of life following cardiac surgery. Identifying reliable biomarkers for predicting POCD could improve patient outcomes and perioperative care. Among these, S100 calcium-binding protein beta (S100β) and neuron-specific enolase (NSE) have emerged as promising indicators of cerebral injury and neurocognitive dysfunction.

Comparative Analysis of Shear Bond Strength of Four Adhesive Systems on Primary Dentin.

Objective: This study aimed to conduct a comparative evaluation of the shear bond strength of etch and rinse (Single Bond 2), two-step self-etch (Clearfil SE) and one-step self-etch (Go Bond SDI and G-Premio Bond) bonding agents applied to primary teeth, using a universal testing machine.

Material And Methods: The sample was divided into four groups: Group A incorporated Single Bond 2, Group B constituted Clearfil SE, Group C constituted Go Bond SDI, and Group D constituted G-Premio Bond. In each group, 14 out of the total 56 primary canine teeth were considered.

Games to Improve the Clinical Skills of Nursing Students: Systematic Review of Current Evidence.

Background: As medical education evolves, incorporating innovative teaching methods is crucial for developing nursing students' critical thinking and problem-solving skills. Game-based learning (GBL) has gained popularity, engaging students through immersive experiences and allowing personalized learning.

Objective: This systematic review aimed to investigate the impact of educational games on outcomes of clinical nursing skills.

Association of triglyceride glucose-body mass index (TyG-BMI) with metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis.

Background: TyG-BMI has been proposed as a marker of insulin resistance in metabolic-associated fatty liver disease, but its clinical utility remains uncertain. This study aims to evaluate the association between TyG-BMI and metabolic dysfunction-associated steatotic liver disease (MASLD) through a systematic review and meta-analysis, focusing on the diagnostic performance across different subgroups.

Methods: A comprehensive literature search was conducted in PubMed, Scopus, Embase, and Web of Science up to January 20, 2025.

The Effect of Intravenous Dexmedetomidine During Surgery in the Prevention of Shivering After General Anesthesia in Patients Undergoing Spinal Surgery: A Randomized Clinical Trial.

Background: Postoperative shivering is an involuntary, spontaneous, and repetitive contraction of skeletal muscles that causes patient restlessness, increased oxygen consumption, wound infection, surgical bleeding, and cardiac events. Patients undergoing spine surgery in the prone position are particularly susceptible to hypothermia.

Objectives: Given the importance of controlling postoperative shivering in these patients, the present study aimed to investigate the effect of intraoperative dexmedetomidine (Dex) infusion in preventing shivering after general anesthesia in patients undergoing spine surgery in the prone position.

Effectiveness of deep breathing exercises on anxiety, depression and sleep quality in patients undergoing coronary artery bypass surgery.

This study investigated the effect of deep breathing exercises on sleep quality, anxiety, and depression in coronary artery bypass graft patients. This is a clinical trial with 2 parallel groups (intervention, control) that was conducted on 80 patients underwent coronary artery bypass surgery. Participants were randomly assigned to the groups using a computer-generated random sequence.

Non-coding RNAs and Hippo signaling in non-small cell lung cancer: emerging roles as biomarkers and therapeutic targets.

The most common type of cancer and one with a high death rate is lung cancer, especially non-small cell lung cancer (NSCLC), which is mostly brought on by medication resistance, metastasis, and delayed diagnosis. The discovery of non-coding RNAs (ncRNAs), such as circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and microRNAs (miRNAs), has revealed their vital involvement in the pathophysiology of lung cancer by controlling important cellular processes. The Hippo signaling pathway is one of the critical routes impacted by non-coding RNAs.

Impact of fixed orthodontic treatment with and without premolar extraction on gingival display index in men and women.

Fixing a gummy smile is a crucial esthetic treatment. It is unclear if the modality of orthodontic treatment (i.e.

A systematic review on natural products with antimicrobial potential against WHO's priority pathogens.

Background: Antimicrobial resistance (AMR) is a critical global issue, with bacteria increasingly resistant to traditional antibiotics, resulting in more treatment failures and higher mortality rates. Resistance can be defined microbiologically or clinically and arises through genetic mutations or acquired traits. In response to this growing threat, the World Health Organization (WHO) established a priority list of antibiotic-resistant bacteria in 2016 to guide the research and development of new antimicrobial agents.

Effects of fixed orthodontic lingual retainers on PDL stress, root resorption risk, and tooth displacement.

To date, no study has compared the effects of CAD/CAM versus flexible multistrand wire (FMS) retainers in the presence/absence of root resorption and/or alveolar crestal bone resorption on the anterior mandibular teeth's stresses/displacements. Therefore, this simulation was conducted. Developed were 8 mandible models with six anterior teeth.

Bariatric Surgery vs. Low-energy Diet and Cardiometabolic Factors: a Systematic Review and Meta-analysis.

Background: Bariatric surgery and low-energy diets (LED) are established interventions for weight loss and cardiometabolic risk management in individuals with obesity. This systematic review and meta-analysis compares their efficacy in improving cardiometabolic outcomes.

Methods: We performed a systematic search in international databases, including PubMed/MEDLINE, Embase, Scopus, and Web of Science.

Psychometric Evaluation of the Anxiety Assessment Scale for Pregnant Women in Labor in an Iranian Population.

Background: Anxiety Assessment Scale for pregnant women in labor (AASPWL), which includes nine items in two subdomains, has been designed as the first specific tool for assessing the anxiety of pregnant mothers in labor. Anxiety is one of the most common psychological complications of mothers in labor and one of the factors affecting the experience of childbirth and maternal delivery satisfaction. Until now, a questionnaire concerning women's anxiety in labor has not yet been used in Iran.

Analysis of Birth Growth: Using a Mixture Cure Frailty Model.

Background: The birth rate is important in population growth. Concerns are growing over declining birth rates in Iran, as a developing country in the past decade. The present study aimed to examine population growth in Hamadan and the factors influencing the birth rate.

Local Delivery of Melatonin Along With Bone Grafts to Improve Osteogenesis.

This review is an attempt to investigate the effects of local delivery of melatonin along with bone grafts to improve osteogenesis. A systematic literature search was done from January 1970 to December 2023 using PubMed following PRISMA instructions. A structured search was carried out to identify in vivo and in vitro studies.

The Effect of Opioid Use on Esophageal Cancer: A Systematic Review and Meta-analysis.

Background: There is limited research available on the direct effect of opioid use on esophageal cancer. The objective of this systematic review and meta-analysis is to consolidate the results of previous studies and provide an estimate of the pooled relative risk or odds ratio associated with opioid use in relation to the occurrence of esophageal cancer.

Methods: The PRISMA guidelines were utilized to establish a framework for conducting this systematic review and meta-analysis.

Performance of deep learning models for automatic histopathological grading of meningiomas: a systematic review and meta-analysis.

Background: Accurate preoperative grading of meningiomas is crucial for selecting the most suitable treatment strategies and predicting patient outcomes. Traditional MRI-based assessments are often insufficient to distinguish between low- and high-grade meningiomas reliably. Deep learning (DL) models have emerged as promising tools for automated histopathological grading using imaging data.

Risk factors for dental anxiety and cooperativeness in pediatric patients with or without oral habits (bruxism, nail biting, and thumb sucking).

Introduction: Anxiety and fear can deter patients from visiting dentists and can deteriorate their oral health. In children, this can also affect their cooperativeness. No studies exist on potential links between oral habits and dental fear and children's cooperation.

Promotion of skin regeneration in diabetic rats by collagen-based hydrogel incorporated with basic fibroblast growth factor: A histological, molecular, and tensiometrical study.

Diabetic wounds represent a major and costly challenge for diabetic patients, leading to significant morbidity and healthcare expenses. Consequently, extensive research has been dedicated to identifying effective treatments to enhance wound healing. Among these, biological hydrogels have emerged as promising candidates due to their superior properties over traditional materials.

In Vitro Comparison of Flexural Strength of a Bioactive Composite and a Reinforced Hybrid Glass Ionomer.

The present study was conducted to compare the flexural strength of a bioactive composite and a reinforced hybrid glass ionomer (GI). In this in vitro experimental study, 10 rectangular-shaped specimens were fabricated from Activa Bioactive composite (N=5) and EQUIA Forte Coat GI (N=5) using stainless steel molds with internal dimensions of 2×2×25mm according to the manufacturers' instructions. The flexural strength of the specimens was measured with a universal testing machine with the three-point bending test using a load of 50±16N/min at a crosshead speed of 0.