Muscle Proteome Dynamics.

Skeletal muscle demonstrates remarkable malleability and can alter in metabolic and contractile properties in response to changes in environmental stimuli, in particular contractile work. The muscle proteome defines muscle by dictating its functional characteristics and coordinating its adaptive responses to external stimuli. The dynamic aspects of the proteome have not yet been widely studied and most current proteomic data chart changes to the abundance profile or post-translational state of proteins during the process of adaptation.

Machine Learning-Driven radiomics on 18 F-FDG PET for glioma diagnosis: a systematic review and meta-analysis.

Background: Machine learning (ML) applied to radiomics has revolutionized neuro-oncological imaging, yet the diagnostic performance of ML models based specifically on ^18F-FDG PET features in glioma remains poorly characterized.

Objective: To systematically evaluate and quantitatively synthesize the diagnostic accuracy of ML models trained on ^18F-FDG PET radiomics for glioma classification.

Methods: We conducted a PRISMA-compliant systematic review and meta-analysis registered on OSF ( https://doi.

Family Physicians' Feedback on the Feature Design of a Digital Health Platform to Streamline the Care of Older Adults.

: Family physicians are essential to a well-functioning healthcare system; however, they face significant administrative and cognitive burdens that contribute to their burnout and reduce the quality of patient care they provide. Digital health tools offer potential solutions to these problems. This study examined the interface design and features of a digital health platform, Carmi, designed to mitigate administrative inefficiencies and cognitive overload by asynchronous patient data gathering and automated report generation.

Phosphosites of the yeast centrosome component Spc110 contribute to cell cycle progression and mitotic exit.

Spc110 is an essential component of the spindle pole body (SPB), the yeast equivalent of the centrosome, that recruits the γ-tubulin complex to the nuclear side of the SPB to produce the microtubules that form the mitotic spindle. Here, we identified phosphosites S11 and S36 in maternally originated Spc110 and explored their functions in vivo. Yeast expressing non-phosphorylatable Spc110S11A had a distinct spindle phenotype characterised by higher levels of α-tubulin, which was frequently asymmetrically distributed between the two SPBs.

Fabrication and evaluation of electrospun polyacrylonitrile/silver nanofiber membranes for air filtration and antibacterial activity.

Particulate matter and airborne microorganisms are two of the most severe indoor air problems due to their significant risks to human health. Comprehensive research on air filtration with good filtration performance for fine particles and antibacterial function is essential. In this study, after some experimentations and optimization of conditions, polyacrylonitrile (PAN) 10-1% silver nanoparticles (AgNPs) membranes with suitable morphology and uniform diameter distribution are fabricated by an electrospinning method.

The microtubule plus-end tracking protein Bik1 is required for chromosome congression.

During mitosis, sister chromatids congress on both sides of the spindle equator to facilitate the correct partitioning of the genomic material. Chromosome congression requires a finely tuned control of microtubule dynamics by the kinesin motor proteins. In , the kinesin proteins Cin8, Kip1, and Kip3 have a pivotal role in chromosome congression.

Family Physician's and Primary Care Team's Perspectives on Supporting Family Caregivers in Primary Care Networks.

Background: Research, practice, and policy have focused on educating family caregivers to sustain care but failed to equip healthcare providers to effectively support family caregivers. Family physicians are well-positioned to care for family caregivers.

Methods: We adopted an interpretive description design to explore family physicians and primary care team members' perceptions of their current and recommended practices for supporting family caregivers.

Developing a Decision-Making Capacity Assessment Clinical Pathway for Use in Primary Care: a Qualitative Exploratory Case Study.

Background: With an ageing population, the incidence of dementia will increase, as will the number of persons requiring decision-making capacity assessments. For over 10 years, we have trained family physicians in conducting decision-making capacity assessments. Physician feedback post-training, however, has highlighted the need to integrate the decision-making capacity assessment process into the primary care context.

The Seniors' Community Hub: An Integrated Model of Care for the Identification and Management of Frailty in Primary Care.

(1) Background: Integrated models of primary care deliver the comprehensive and preventative approach needed to identify and manage frailty in older people. Seniors' Community Hub (SCH) was developed to deliver person-centered, evidence-informed, coordinated, and integrated care services to older community dwelling adults living with frailty. This paper aims to describe the SCH model, and to present patient-oriented results of the pilot.

An alginate-PHMB-AgNPs based wound dressing polyamide nanocomposite with improved antibacterial and hemostatic properties.

Wound dressing should be impenetrable against microorganisms and it should keep the wound wet. Gauze and polyamide (PA) substrate were treated with various concentrations of AgNPs (25, 50, 75, and 100 ppm), PHMB (0.2, 0.

Medicinal plants used in wound dressings made of electrospun nanofibers.

Nanofibers are a type of nanostructures, which due to their unique properties can be used in wound dressing, and electrospinning is a good way to produce them. The benefits of wound dressings made of electrospun nanofibers include a large surface area to volume ratio, high absorption of secretions from the wound, and high air permeability, mimicking the morphology of extracellular matrix (ECM) of the damaged tissue and the possibility of the gradual release of the drug agents loaded on nanofibers. Because of the adaptability of plants to the body, low side effects and the prevalence of antibiotic resistance, interest in using plants is increasing.

Appropriateness of Medications in Older Adults Living With Frailty: Impact of a Pharmacist-Led Structured Medication Review Process in Primary Care.

Older persons with frailty take multiple medications and are vulnerable to inappropriate prescribing. This study assesses the impact of a team-based, pharmacist-led structured medication review process in primary care on the appropriateness of medications taken by older adults living with frailty. This was a quasi-experimental pretest-posttest design in 6 primary care practices within an academic clinic in Edmonton, Alberta, Canada.

Identification of Frailty in Primary Care: Feasibility and Acceptability of Recommended Case Finding Tools Within a Primary Care Integrated Seniors' Program.

Case finding for frailty is recommended as part of routine clinical practice. We aimed to test feasibility and acceptability of three recommended case finding tools in primary care as part of an integrated seniors' program. Program of Research to Integrate Services for the Maintenance of Autonomy-7 (PRISMA-7), 4-m walk test, and electronic frailty index (eFI) were used as frailty case finding tools for a target population of community-dwelling seniors ≥65 years of age enrolled in a seniors' program within an academic primary care clinic in Alberta, Canada.

Calendula officinalis extract/PCL/Zein/Gum arabic nanofibrous bio-composite scaffolds via suspension, two-nozzle and multilayer electrospinning for skin tissue engineering.

This work investigates the incorporation of the Calendula officinalis (C. officinalis) extract in electrospun fiber scaffolds composed of poly (ε-caprolactone) (PCL), Zein and gum arabic (GA). Three methods of electrospinning were used: suspension electrospinning, in which C.

Correction to: A cross-sectional study examining convergent validity of a frailty index based on electronic medical records in a Canadian primary care program.

Following the publication of this article [1], the authors reported a typesetting error in the "Results" section.

A cross-sectional study examining convergent validity of a frailty index based on electronic medical records in a Canadian primary care program.

Background: An electronic frailty index (eFI) has been developed and validated in the UK; it uses data from primary care electronic medical records (EMR) for effective frailty case-finding in primary care. This project examined the convergent validity of the eFI from Canadian primary care EMR data with a validated frailty index based on comprehensive geriatric assessment (FI-CGA), in order to understand its potential use in the Canadian context.

Methods: A cross-sectional validation study, using data from an integrated primary care research program for seniors living with frailty in Edmonton, AB.

Fabrication and characterization of PCL/zein/gum arabic electrospun nanocomposite scaffold for skin tissue engineering.

The main role of tissue engineering is to produce the artificial tissue for replacing the biological functions in tissue regeneration and wounds healing. The purpose of this research was to produce porous nanofiber scaffold by electrospinning to compensate deep skin damages. In order to simulate a scaffold similar to the natural extracellular matrix of the skin, a mixture of corn protein (Zein), polycaprolactone (PCL) and gum arabic (GA) was used with different concentrations and ratios.

Application of an electronic Frailty Index in Australian primary care: data quality and feasibility assessment.

Background: The primary care setting is the ideal location for identifying the condition of frailty in older adults.

Aims: The aim of this pragmatic study was twofold: (1) to identify data items to extract the data required for an electronic Frailty Index (eFI) from electronic health records (EHRs); and (2) test the ability of an eFI to accurately and feasibly identify frailty in older adults.

Methods: In a rural South Australian primary care clinic, we derived an eFI from routinely collected EHRs using methodology described by Clegg et al.

Improving Care Experiences, Efficiencies and Quality of Care for Seniors in Alberta.

Improving Care Experiences, Efficiencies and Quality of Care for Seniors in Alberta Forum was held to explore the current challenges and opportunities in seniors' care. A diverse group of 53 attendees, representing a cross section of healthcare organizations, front-line healthcare providers, researchers and patients, participated in facilitative, small group discussions to share and propose solutions to barriers to coordinating and integrating care for the senior population across the continuum within the Edmonton zone, to comment on a standardized assessment that may inform integrated care and support planning and to outline steps towards health information continuity.

Infection of placental trophoblasts by Toxoplasma gondii.

How the intracellular parasite Toxoplasma gondii causes placental inflammation and infects the fetus is unknown. By use of a culture model of primary human trophoblasts, we examined the consequences of infection by a virulent strain of T. gondii.