Catalytic acidic deep eutectic mixture for efficient and promising synthesis of quinazolinone and quinoxaline derivatives.

A facilitated and economical protocol was designed to synthesize novel acidic deep eutectic mixture (ADEM) from urea/SbCl/HCl as commercially available substrates for the first time. Urea acts as a hydrogen bond donor, SbCl serves as a Lewis acid catalyst, and HCl provides ionic conductivity and an acidic environment. The architectural chemical composition of acidic deep eutectic mixture was confirmed using EDX and FT-IR spectroscopy.

A novel acidic deep eutectic solvent for sustainable and efficient coumarin synthesis.

A novel acidic deep eutectic solvent (ADES) has been developed as an efficient and sustainable alternative to traditional solvents and catalysts in organic synthesis. The ADES was synthesized through a simple one-pot procedure involving benzyl chloride, 2-(dimethylamino)ethanol, and p-toluenesulfonic acid, yielding a homogeneous liquid. Structural and compositional characterization was performed using FTIR and NMR spectroscopy.

Green synthesis of imidazole derivatives in a ternary deep eutectic solvent system.

Deep eutectic solvents (DESs) have gained recognition for their sustainable characteristics and demonstrated potential for various applications in chemical processes. Their biodegradability and recyclability make them an attractive alternative for sustainable chemistry. Herein, we investigated the application of novel ternary DES as a reaction medium and recyclable catalyst for one-pot, multicomponent synthesis of tri and tetra-substituted imidazole derivatives under mild conditions.

Correction: DCID-mediated esterification of carboxylic acids with alcohols under mild conditions.

[This corrects the article DOI: 10.1039/D3RA04048H.].

Long-time irradiation effect on corrosion behavior of aluminum alloy in pool water of low-power research reactor.

This study conducted an evaluation of the corrosion behavior of an aluminum alloy utilized in the Isfahan Miniature Neutron Source Reactor (MNSR). The component analyzed, dry channel (DC), had been exposed to radiation for 12 years in a water environment within the reactor pool since its installation. To determine the effect of radiation on the corrosion of the LT-21 aluminum alloy used in the DC, different parts of the pipe were sampled and various tests were performed.

DCID-mediated esterification of carboxylic acids with alcohols under mild conditions.

DCID (Dichloroimidazolidinedione) 2 is used as a novel coupling reagent for the esterification of carboxylic acids with alcohols at room temperature. The reaction represents the first DCID-promoted esterification under mild conditions with good to excellent yields. Reactions can proceed smoothly with those bearing electron-withdrawing and donating group(s) on the carboxylic acids and benzyl alcohols at ambient temperature.

Direct synthesis of amides and imines by dehydrogenative homo or cross-coupling of amines and alcohols catalyzed by Cu-MOF.

Oxidative dehydrogenative homo-coupling of amines to imines and cross-coupling of amines with alcohols to amides was achieved with high to moderate yields at room temperature in THF using Cu-MOF as an efficient and recyclable heterogeneous catalyst under mild conditions. Different primary benzyl amines and alcohols could be utilized for the synthesis of a wide variety of amides and imines. The Cu-MOF catalyst could be recycled and reused four times without loss of catalytic activity.

Synthesis and characterization of epoxide impurities of abiraterone acetate.

Abiraterone acetate is an antiandrogen steroidal drug that is used to treat patients with metastatic prostate cancer. During the process development of abiraterone acetate, two process α and β-epoxy abiraterone acetate related impurities (2 and 3) were observed along with the final API. In the present work we describe the synthesis of these two known impurities using abiraterone acetate in the presence of hydrogen peroxide and acetic acid as oxidizing agent.

Novel Method for the Isolation of Proteins and Small Target Molecules from Biological and Aqueous Media by Salt-Assisted Phase Transformation of Their PEGylated Recognition Counterparts.

An efficient and simple method for the application of PEGylated affinity ligands in precipitative isolation of protein target molecules (TMs) from a biological fluid such as blood serum or small target molecules from an aqueous medium is presented for the first time. This approach is based on the high binding specificity of PEGylated recognition molecules (PEG-RMs) to their TMs and the unique physicochemical properties of PEG that result in their salt-assisted phase transformation. Addition of PEG-RM to blood serum results in the formation of an RM-specific macromolecular complex (PEG-RM + TM → PEG-RM.

An alginate-PHMB-AgNPs based wound dressing polyamide nanocomposite with improved antibacterial and hemostatic properties.

Wound dressing should be impenetrable against microorganisms and it should keep the wound wet. Gauze and polyamide (PA) substrate were treated with various concentrations of AgNPs (25, 50, 75, and 100 ppm), PHMB (0.2, 0.

Ethanol-Drop Grinding Approach: Cadmium Oxide Nanoparticles Catalyzed the Synthesis of [1,3]Dioxolo[g][1]benzopyran-6-carboxylic Acids and Pyrido[d]pyrimidine-7-carboxylic Acids.

Aim And Objective: In the last decades, it has extensively been verified that nanostructured transition metal oxides emerge as inexpensive, available and extremely efficient heterogeneous catalysts in chemical transformations. The high electrical conductivity, high carrier concentration, and improved reactivity in cadmium oxide nanoparticles (CdO NPs) make it as a potential candidate for applications in the fields of nanocatalysis. [1]Benzopyran and pyridopyrimidine derivatives compose major classes of heterocyclic compounds, which have a wide spectrum of biological activities.

Anion recognition by urea metal-organic frameworks: remarkable sensitivity for arsenate and fluoride ions.

Functionalized metal-organic frameworks (F-MOFs) are known as a promising chemical sensors since they have specific merits like fixed functionalized ligands projecting into the pores which can be utilized to enhance sensitivity and selectivity. Due to the important role of anions in biological process and environmental systems, there is an increasing interest in synthesis and design of new receptors for anions. Urea groups can operate as a hydrogen bond donating site with hydrogen bond acceptor molecules.

Molecular Engineering of Simple Metal-Free Organic Dyes Derived from Triphenylamine for Dye-Sensitized Solar Cell Applications.

Two new metal-free organic sensitizers, L156 and L224, were designed, synthesized, and characterized for application in dye-sensitized solar cells (DSCs). The structures of the dyes contain a triphenylamine (TPA) segment and 4-(benzo[c][1,2,5]thiadiazol-4-yl)benzoic acid as electron-rich and -deficient moieties, respectively. Two different π bridges, thiophene and 4,8-bis(4-hexylphenyl)benzo[1,2-b:4,5-b']dithiophene, were used for L156 and L224, respectively.

One-pot synthesis of amides the oxidative amidation of aldehydes and amines catalyzed by a copper-MOF.

An efficient method for the oxidative amidation of aldehydes with primary aromatic and aliphatic amines has been developed for the synthesis of a wide variety of amides using inexpensive Cu(BDC)DABCO (Cu-metal-organic framework [MOF]) as a recyclable heterogeneous catalyst, and -chlorosuccinimide and aqueous -butyl hydroperoxide as oxidants in acetonitrile. This amidation reaction is operationally straightforward and provides secondary amides in good yields in most cases, utilizing inexpensive and readily available reagents under mild conditions.

Calendula officinalis extract/PCL/Zein/Gum arabic nanofibrous bio-composite scaffolds via suspension, two-nozzle and multilayer electrospinning for skin tissue engineering.

This work investigates the incorporation of the Calendula officinalis (C. officinalis) extract in electrospun fiber scaffolds composed of poly (ε-caprolactone) (PCL), Zein and gum arabic (GA). Three methods of electrospinning were used: suspension electrospinning, in which C.

Fabrication and characterization of PCL/zein/gum arabic electrospun nanocomposite scaffold for skin tissue engineering.

The main role of tissue engineering is to produce the artificial tissue for replacing the biological functions in tissue regeneration and wounds healing. The purpose of this research was to produce porous nanofiber scaffold by electrospinning to compensate deep skin damages. In order to simulate a scaffold similar to the natural extracellular matrix of the skin, a mixture of corn protein (Zein), polycaprolactone (PCL) and gum arabic (GA) was used with different concentrations and ratios.

Cu-MOF: an efficient heterogeneous catalyst for the synthesis of symmetric anhydrides the C-H bond activation of aldehydes.

In this paper, an efficient and straightforward synthetic approach for the preparation of a number of symmetric carboxylic anhydrides was reported using Cu(BDC)(DABCO) as an efficient heterogeneous catalyst the C-H bond activation of aldehydes with excellent yields and simple work up. This C-H bond activation reaction appears simple and convenient, has a wide substrate scope and makes use of cheap, abundant, and easily available reagents. The Cu-MOF catalyst was recycled and reused four times without any loss of catalytic activity.

Erodibility of calcareous soils as influenced by land use and intrinsic soil properties in a semiarid region of central Iran.

The most important properties affecting the soil loss and runoff were investigated, and the effects of land use on the soil properties, together with the erodibility indices in a semiarid zone, central Iran, were evaluated. The locations of 100 positions were acquired by cLHS and 0-5-cm surface soil layer samples were used for laboratory analyses from the Borujen Region, Chaharmahal-Va-Bakhtiari Province, central Iran. To measure in situ runoff and soil erodibility of three different land uses comprising dryland, irrigated farming, and rangeland, a portable rainfall simulator was used.

Molecular Design of Efficient Organic D-A-π -A Dye Featuring Triphenylamine as Donor Fragment for Application in Dye-Sensitized Solar Cells.

A metal-free organic sensitizer, suitable for the application in dye-sensitized solar cells (DSSCs), has been designed, synthesized and characterized both experimentally and theoretically. The structure of the novel donor-acceptor-π-bridge-acceptor (D-A-π-A) dye incorporates a triphenylamine (TPA) segment and 4-(benzo[c][1,2,5]thiadiazol-4-ylethynyl)benzoic acid (BTEBA). The triphenylamine unit is widely used as an electron donor for photosensitizers, owing to its nonplanar molecular configuration and excellent electron-donating capability, whereas 4-(benzo[c][1,2,5]thiadiazol-4-ylethynyl)benzoic acid is used as an electron acceptor unit.

Resolution of Racemic Mixtures by Phase Transition of PEGylated Resolving Agents.

A novel, efficient, and simple method for the resolution of racemic mixtures is presented in which PEGylated resolving agents are subjected to diastereomeric complex formation in alcohols. The resulting complexes then undergo temperature-assisted phase transition, affording a precipitate that is enriched in one enantiomer and separable by filtration. In an aqueous solution, phase transition can be caused by the methods used in the precipitation of poly(ethylene glycol) (e.

Electrospinning of poly(vinyl alcohol)-water-soluble quaternized chitosan derivative blend.

Defect free mats containing a cationic polysaccharide, chitosan derivative such as N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride (HTCC), have been prepared using electrospinning of an aqueous solution of poly(vinyl alcohol) (PVA)-HTCC blends. HTCC, a water-soluble derivative of chitosan, was synthesized via the reaction between glycidyl-trimethylammonium chloride and chitosan. Solutions of PVA-HTCC Blends were electrospun.

Kneading ball-milling and stoichiometric melts for the quantitative derivatization of carbonyl compounds with gas-solid recovery.

A ray of hope for the environment is sustainable and green synthesis without the production of (toxic) waste. Solvent-free stoichiometric melting or kneading ball-milling reactions of aldehydes or ketones with carbonyl reagents yields arylhydrazones and oximes in quantitative yield. The carbonyl compounds can be quantitatively recovered from the imino derivatives by using gaseous NO(2).

Sustainable synthesis of aldehydes, ketones or acids from neat alcohols using nitrogen dioxide gas, and related reactions.

Benzylic alcohols are quantitatively oxidized by gaseous nitrogen dioxide to give pure aromatic aldehydes. The reaction gas mixtures are transformed to nitric acid, which renders the processes free of waste. The exothermic gas-liquid or gas-solid reactions profit from the solubility of nitrogen dioxide in the neat benzylic alcohols.