Possible association between Toxoplasma gondii infection and autism spectrum disorder.

Toxoplasma gondii is a neurotropic apicomplexan protozoan estimated to affect approximately 30% of the global population. In this review, we aimed to examine scientific evidence on the potential role of T. gondii infection in the development of autism spectrum disorder (ASD), a heterogeneous neurodevelopmental disorder.

Design and immunological evaluation of a multi-epitope vaccine candidate against incorporating MIC13, GRA1, and SAG1 antigens in BALB/c mice.

Toxoplasmosis, caused by the apicomplexan parasite , is a globally significant yet neglected disease that can cause serious clinical consequences in humans and extensive losses in the livestock industry. However, no effective vaccine has been provided for this parasite, so this study was designed to evaluate the immunogenicity of a chimeric multi-epitope antigen as a potential toxoplasmosis vaccine candidate in a murine model. The multi-epitope vaccine candidate, designed with bioinformatics tools, MGS: a chimera of MIC13, GRA1, and SAG1 antigens, was expressed in BL21 and purified by immobilized metal affinity chromatography using a His Ni-NTA column.

The global prevalence of Giardia infection in horses: A systematic review and meta-analysis.

Giardia duodenalis as a common zoonotic parasite is a public health problem infecting humans and a wide range of animals, including horses. This systematic review and meta-analysis was conducted to estimate the global pooled prevalence of Giardia infection in horses. Literature searches were conducted using databases including Scopus, ScienceDirect, PubMed, Web of Science and ProQuest to December 2023.

Prevalence of toxoplasmosis in natural ungulates as human zoonotic meat-borne pathogens: A systematic review and meta-analysis.

The increasing consumer interest in game meat, along with the potential transmission of Toxoplasma gondii from game meat to humans, poses significant challenges in assessing the related public health risks. The diverse transmission pathways of T. gondii and its ability to infiltrate host organisms offer an excellent opportunity for enhancing our comprehension of this pathogen's transmission dynamics.

Evaluation of the Relationship between QT Dispersion in ECG and Response to Primary PCI in Patients with Acute Myocardial Infarction.

Background: St-elevation myocardial infarction (STEMI) is a serious condition that occurs when the blood flow to one or more coronary arteries is blocked, leading to damage or death of the heart muscle (myocardial injury or necrosis). The present study aimed to compare QTc and QTd intervals in patients with STEMI before and 90 minutes after treatment in Booali Sina Hospital, Qazvin, Iran.

Methods: The present study is an analytical cross-sectional study.

Structural Prediction and Antigenic Analysis of ROP18, MIC4, and SAG1 Proteins to Improve Vaccine Design against : An Approach.

Background: Toxoplasmosis is a cosmopolitan infectious disease in warmblooded mammals that poses a serious worldwide threat due to the lack of effective medications and vaccines.

Aims: The purpose of this study was to design a multi-epitope vaccine using several bioinformatics approaches against the antigens of .

Methods: Three proteins of , including ROP18, MIC4, and SAG1 were analyzed to predict the most dominant B- and T-cell epitopes.

Comparing the quality of life of adolescent girls with and without polycystic ovary syndrome and identifying the predictor factors.

Objectives: Polycystic Ovary Syndrome (PCOS) is a complex hormonal disorder that affects the endocrine glands and reproductive processes in adolescent girls, potentially impacting their quality of life. This study aims to compare the quality of life between adolescent girls with PCOS and those without PCOS.

Methods: The present study is an analytical cross-sectional study.

Global prevalence of enterobiasis in young children over the past 20 years: a systematic review and meta-analysis.

Parasitic infections are the most common diseases worldwide, and enterobiasis is a common parasitic infection in children. Various studies have reported on the prevalence of Enterobius vermicularis in different regions of the world. However, no study has gathered and analyzed this data systematically.

The double-sided effects of Mycobacterium bovis bacillus Calmette-Guérin vaccine on helminthic infections – current data and future prospects.

Bacillus Calmette-Guérin (BCG), a live attenuated strain derived from an isolate of Mycobacterium bovis, is one of the childhood vaccinations widely used against tuberculosis (TB). In addition to its effects on mycobacterial diseases, the information has shown the protection effect of BCG in helminthic diseases. In the current review, the role of BCG vaccine in non-specific protection helminthic infection is reviewed.

Vaccine Design and Expression of the Multi-Component Protein Candidate against the Parasite from MIC13, GRA1, and SAG1 Antigens.

Background: We aimed to design a B and T cell recombinant protein vaccine of with approach. MIC13 plays an important role in spreading the parasite in the host body. GRA1 causes the persistence of the parasite in the parasitophorous vacuole.

Phylogenetic analysis of avian schistosome Trichobilharzia regenti (Schistosomatidae, Digenea) from naturally infected hosts in northern Iran.

Background: Trichobilharzia regenti (T. regenti) is an avian schistosomatid fluke species that causes human cercarial dermatitis (HCD) in areas of aquaculture in northern Iran. Understanding the phylogenetic relationships and genetic diversity of this thread-like fluke will deepen our thoughtful of avian schistosomiasis epidemiology and lead to more effective HCD control in the region.

Subtype distribution of sp. isolated from humans in Iran: a systematic review and meta-analysis.

Aim: This systematic review and meta-analysis evaluated the subtyped sp. isolated from humans in Iran.

Background: sp.

Enhancement of immune responses by vaccine potential of three antigens, including ROP18, MIC4, and SAG1 against acute toxoplasmosis in mice.

Toxoplasma gondii (T. gondii) causes considerable financial losses in the livestock industry and can present serious threats to pregnant women, as well as immunocompromised patients. Therefore, it is required to design and produce an efficient vaccine for controlling toxoplasmosis.

The effect of coronavirus infection on QT and QTc intervals of hospitalized patients in Qazvin, Iran.

Electrocardiographic (ECG) changes have been investigated in the condition of coronavirus disease (COVID-19) indicating that COVID-19 infection exacerbates arrhythmias and triggers conduction abnormalities. However, the specific type of ECG abnormalities in COVID-19 and their impact on mortality fail to have been fully elucidated. The present retrospective, tertiary care hospital-based cross-sectional study was conducted by reviewing the medical records of all patients diagnosed with COVID-19 infection who were admitted to Booali Sina Hospital in Qazvin, Iran from March to July 2020.

The effect of risperidone and electroconvulsive therapy on corrected QT interval in electrocardiogram of psychiatric patients.

Background: Some types of antidepressants and antipsychotic medications have cardiovascular side effects that can be life-threatening. Electroconvulsive therapy (ECT) is capable of generating physiological stress and may lead to increased QT interval followed by arrhythmias. Risperidone can also increase the risk of arrhythmia by increasing the corrected QT (QTc) interval.

Effect of Emotional Intelligence Training on Methadone-Treated Methamphetamine Users in Qazvin, Iran.

Background: Drug users have lower emotional intelligence (EQ) than other members of society. This study aimed to determine the effect of EQ training on methadone-treated methamphetamine (meth) users.

Methods: This randomized clinical trial with a pretest-posttest control group design was conducted on methadone-treated meth users referring to the Drop-in Center in Qazvin, Iran.

Molecular Identification of Infection in Aborted Fetuses of Sheep, Cattle, and Goats in Mazandaran Province, Northern Iran.

Background: We aimed to identify DNA in the brain samples of aborted fetuses of cattle, goats, and sheep in Mazandaran, northern Iran, using PCR.

Methods: In total, 133 aborted fetuses (51 sheep, 78 cattle, and 4 goats) were randomly collected from different stages of gestation in various regions of Mazandaran, Iran, from Mar 2016 to May 2017. The DNA was extracted from all the brain samples using phenol chloroform isoamyl alcohol instructions.

Detection and Molecular Characterization of Potentially Pathogenic Free-Living Amoebae from Recreational and Public Soils in Mazandaran, Northern Iran.

Background: Free-living amoeba (FLA) belonging to spp, , and are the soil-born protozoa. This study aimed to survey the occurrence of FLA, including spp, , spp., and spp.

Protective efficacy by a novel multi-epitope vaccine, including MIC3, ROP8, and SAG1, against acute Toxoplasma gondii infection in BALB/c mice.

Toxoplasma gondii is an intracellular apicomplexan parasite, which can cause a serious infectious disease in pregnant women and immunocompromised individuals. Therefore, the development of a polyvalent vaccine consisting of all stages of the parasite life cycle using the epitopes from tachyzoites, bradyzoites, and sporozoites is likely to be required for complete protective immunity. In this study, we designed protein vaccine candidate based on the prediction of specific epitopes (i.

Global prevalence status of avian schistosomes: A systematic review with meta-analysis.

Objectives: Human cercarial dermatitis (HCD) is a water-borne zoonotic parasitic disease. Cercariae of the avian schistosomes of several genera are frequently recognized as the causative agent of HCD. Various studies have been performed regarding prevalence of bird schistosomes in different regions of the world.

The global serological prevalence of Toxoplasma gondii in felids during the last five decades (1967-2017): a systematic review and meta-analysis.

Background: Felids (domestic and wild cats) are important in the epidemiology of the parasite Toxoplasma gondii because they are the only hosts that can excrete the environmentally resistant oocysts. We conducted a systematic review and meta-analysis to estimate the global prevalence of T. gondii in species of the family Felidae.