Is the Botulinum Toxin Injection Into the Cricopharyngeal Sphincter Precipitate Laryngopharyngeal Reflux Symptoms in Patients With Retrograde Cricopharyngeal Dysfunction?

Objective: To investigate the potential relationship between retrograde cricopharyngeal dysfunction (R-CPD) and laryngopharyngeal reflux disease (LPRD) at baseline and whether cricopharyngeal sphincter paralysis botulinum toxin injection (BTI) is associated with an increase of LPRD symptoms in treated R-CPD patients.

Methods: Patients with clinical diagnosis of R-CPD were prospectively recruited from two European hospitals. Controls included individuals unable to burp without troublesome symptoms (CT1) and healthy subjects able to burp (CT2).

Effectiveness of Diet Recommendations for Laryngopharyngeal Reflux Disease: A Systematic Review for Clinical Practice and Studies.

Objective: To review the current literature dedicated to the effectiveness of the diet recommendations for laryngopharyngeal reflux disease (LPRD).

Methods: Two independent investigators conducted a PubMED, Scopus, and Cochrane Library database search for studies investigating the effectiveness of anti-reflux diet in LPRD patients. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements and the Methodological Index for Non-Randomized Studies (MINORS) tool were considered for study analyses.

Laryngeal Reinnervation Techniques for Unilateral Vocal Fold Paralysis-Clinical Outcomes and Surgical Approaches: A Systematic Review and Meta-Analysis.

Background: Laryngeal reinnervation is a promising therapeutic option for unilateral vocal fold paralysis (UVFP). However, the efficacy of the different techniques remains controversial.

Objectives: To systematically evaluate clinical outcomes and surgical approaches employed for laryngeal reinnervation in UVFP, using both objective and subjective parameters.

Salivary Pepsin Measurement in Laryngopharyngeal Reflux Disease: A Systematic Review of Diagnostic Accuracy and Performance.

Objective: To analyze the methods used for digestive enzyme measurements in saliva of patients with laryngopharyngeal reflux disease (LPRD) and to investigate their respective diagnostic performances.

Methods: Three independent investigators conducted a PubMED, Scopus, and Cochrane Library database search for studies investigating the digestive saliva enzyme measurements in LPRD patients according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements.

Results: Of the 183 screened studies, 38 studies met the inclusion criteria (1461 females (47.

Diagnostic Performance of ChatGPT-4o in Analyzing Oral Mucosal Lesions: A Comparative Study with Experts.

this pilot study aimed to evaluate the diagnostic accuracy of ChatGPT-4o in analyzing oral mucosal lesions from clinical images. : a total of 110 clinical images, including 100 pathological lesions and 10 healthy mucosal images, were retrieved from Google Images and analyzed by ChatGPT-4o using a standardized prompt. An expert panel of five clinicians established a reference diagnosis, categorizing lesions as benign or malignant.

Platelet-Rich Plasma for Posttraumatic Olfactory Dysfunction: Preliminary Report of 33 Patients.

The platelet-rich plasma (PRP) injection into the olfactory clefts has been suggested as an effective treatment for long-lasting post-viral olfactory dysfunction (OD). Currently, no prospective clinical studies have been conducted in other OD etiologies. In this preliminary study, the PRP injection outcomes were investigated in 33 posttraumatic OD patients (19 females; mean duration: 55.

Validity and Reliability of the Singer Reflux Symptom Score (sRSS).

: To investigate the reliability and validity of the Singer Reflux Symptom Score (sRSS), a new patient-reported outcome questionnaire documenting the severity of reflux symptoms in singing voice is proposed. : Amateur and professional singers consulting the European Reflux Clinic for laryngopharyngeal reflux disease (LPRD) symptoms and findings were prospectively recruited from January 2022 to February 2023. The diagnosis was based on a Reflux Symptom Score (RSS) > 13 and Reflux Sign Assessment (RSA) > 14.

Pleomorphic Adenoma: Extracapsular Dissection vs. Superficial Parotidectomy-An Updated Systematic Review and Meta-Analysis.

: The aim of our study was to evaluate clinical outcomes in patients with small pleomorphic adenoma (PA) after extracapsular dissection (ED) versus superficial parotidectomy (SP). : Following the PRISMA guidelines, a systematic review covering the years from 1950 to 2025 was conducted using the Pubmed/MEDLINE, Cochrane Library, Scopus, Ovid MEDLINE and Embase databases. A single-arm meta-analysis was performed to evaluate intraoperative capsular rupture, recurrence, transient and permanent facial nerve palsy, Frey's syndrome, salivary fistula, seroma and hematoma of patients who underwent ED vs.

Surgical and Voice Outcomes of Office-Based Vocal Fold Dysplasia and Leukoplakia Surgery: A Systematic Review.

Objective: To investigate the surgical and voice quality outcomes of office-based laryngeal surgery for patients with laryngeal dysplasia and leukoplakia.

Data Sources: PubMed, Google scholar, and Cochrane databases.

Review Methods: Three independent investigator search databases for studies reporting surgical or voice quality outcomes of patients treated with office-based surgery for vocal fold dysplasia or leukoplakia.

Accuracy and Clinical Findings of Saliva Digestive Biomarkers in Laryngopharyngeal Reflux Disease.

Objective: To evaluate the diagnostic performance of multiple digestive enzyme biomarkers in detecting and characterizing laryngopharyngeal reflux disease (LPRD).

Methods: Patients with LPRD at the 24-h hypopharyngeal-esophageal multichannel intraluminal impedance-pH testing (HEMII-pH) were consecutively recruited from January 2020 to May 2024 from two European hospitals. The control group consisted of adults without symptoms.

French Translation and Validation of an Objective Swallowing Rating Scale: The PAS.

Introduction: Oropharyngeal dysphagia is a severe swallowing disorder with consequences that can be life-threatening or impair quality of life. One of the major risks is laryngeal penetration, which can lead to the bolus being aspirated. It is best assessed and quantified using The Penetration Aspiration Scale (PAS), which is a validated tool in English.

Therapeutic Outcomes of Vocal Fold Botulinum Toxin Injections for Exercise-Induced Laryngeal Obstruction.

Objective: To investigate the effectiveness of vocal fold botulinum toxin injection (BTI) for treating patients with the glottic form of exercise-induced laryngeal obstruction (EILO).

Methods: The outcomes of 13 patients treated with BTI for a confirmed diagnosis of EILO between May 2017 and July 2024 were retrospectively analyzed. Electromyography-guided bilateral BTI (1.

Airway Management in Obstructive Sleep Apnea: A Comprehensive Review of Assessment Strategies, Techniques, and Technological Advances.

: Airway management in patients with obstructive sleep apnea (OSA) presents unique challenges for anesthesiologists and other airway practitioners. This comprehensive review examines current evidence and clinical practices for managing difficult airways in this high-risk population. OSA is characterized by specific anatomical and physiological alterations that increase both the likelihood of encountering difficult intubation and the risk of rapid desaturation during airway manipulation.

Micro- and Nanoplastic Toxicity in Upper Respiratory Tract: A Scoping Review.

Objectives: To review the current literature findings dedicated to the toxicity of nano- and microplastics (NMPs) in the upper respiratory tract.

Data Sources: PubMED, Cochrane Library and Embase databases.

Review Methods: Three independent investigators conducted the literature search for the documentation and toxicity of NMP in the upper respiratory tract according to the PRISMA statements.

Voice Quality Changes After Laryngopharyngeal Reflux Disease Treatment: A Systematic Review.

Objective: To review the current literature dedicated to the voice quality changes throughout laryngopharyngeal reflux disease (LPRD) treatment.

Methods: Two independent investigators conducted a literature search for studies investigating the voice quality changes after treatment in LPRD patients through PubMED, Scopus, BioMed Central, Biological Abstracts, and Cochrane Library databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements.

Results: Twenty-seven studies (1470 patients, 48.

Treatment for Laryngopharyngeal Reflux Disease: A Systematic Review of Controlled Studies.

ImportanceProton pump inhibitors (PPIs) do not demonstrate superiority over placebo in laryngopharyngeal reflux disease (LPRD). While poorly used, many alternative medical treatments exist for controlling the gastroduodenal and gastro-pharyngeal reflux processes.ObjectiveTo investigate the clinical findings of controlled studies comparing therapeutic regimens for treating LPRD.

Clinical Profiles and Proton Pump Inhibitor Discontinuation Outcomes in Laryngopharyngeal Reflux Disease.

Objective: To investigate the clinical presentation and weaning of patients with chronic proton pump inhibitor (PPI) therapy and laryngopharyngeal reflux disease (LPRD).

Study Design: Prospective controlled study.

Methods: Patients with LPRD symptoms despite ongoing PPI therapy were prospectively recruited from two centers.

Computational Fluid Dynamics Simulations to Personalize Nasal Irrigations.

: Proper nasal irrigation techniques are essential for treating nasal and sinus conditions, influencing drug delivery efficiency and patient comfort. This study evaluates how different head positions-upright, right-tilted, and left-tilted-affect the distribution of saline solution in the nasal cavity and maxillary sinus using computational fluid dynamics (CFD). : CFD simulations were conducted on a CT-based model of a healthy adult.

Correlation Between Anxiety, Depression, and Self-Perceived Hoarseness: A Systematic Review of the Literature.

Objective: This review aims to evaluate the correlation between anxiety, depression, and self-perceived hoarseness in patients with dysphonia.

Study Design: Systematic review.

Methods: A systematic search of Medline, PubMed, and Cochrane databases was performed.

Regional Disparities in Head and Neck Cancer Management: A Global Cross-Sectional Survey of the World Federation of ENT Societies.

Objective: To outline global variations in head and neck cancer care practices and resource availability across disparate geographic locations and sites of care.

Methods: We conducted a cross-sectional worldwide survey following STROBE and CHERRIES guidelines in September-December 2024 under the aegis of the World Federation of ENT Societies (IFOS) and Young Otolaryngologists of IFOS (YO-IFOS). The survey was conducted in the form of standardized case vignettes for common clinical scenarios for various head and neck subsites, practice setting characteristics, and resource availability assessment.

Detection and Patterns of Pharyngeal Reflux Events With Two Ambulatory Pharyngeal Impedance-pH Monitoring Systems: A Comparative Study.

Objective: To investigate the detection and patterns of pharyngeal reflux events in laryngopharyngeal reflux disease (LPRD) patients according to the type of ambulatory hypopharyngeal-esophageal multichannel intraluminal impedance-pH monitoring (HEMII-pH) system used and assessed whether potential HEMII-pH differences impact the pretreatment to post treatment findings.

Methods: Patients with laryngopharyngeal symptoms and findings and an objective LPRD diagnosis were prospectively recruited from the European Reflux Clinic from January 2017 to December 2024. The objective diagnosis was supported by two different HEMII-pH systems (Medtronic and Sandhill).