Comparative Assessment of Conventional and Sustainable Extraction Methods for Essential Oils and Phenolic Compounds From Ammodaucus Leucotrichus.

The aim of this study was to identify the most suitable extraction methods for isolating essential oils and polyphenols from Ammodaucus leucotrichus. Essential oils were extracted using hydrodistillation (HD), microwave-assisted HD (MW-HD) and microwave-assisted steam distillation (MW-SD), while polyphenols were obtained via maceration (MAC), Soxhlet (SOX), ultrasonic extraction (ULTR), and microwave-assisted extraction (MW). HD yielded the highest amount of essential oil (1.

Micro- and Nanoplastic Toxicity in Upper Respiratory Tract: A Scoping Review.

Objectives: To review the current literature findings dedicated to the toxicity of nano- and microplastics (NMPs) in the upper respiratory tract.

Data Sources: PubMED, Cochrane Library and Embase databases.

Review Methods: Three independent investigators conducted the literature search for the documentation and toxicity of NMP in the upper respiratory tract according to the PRISMA statements.

Molecular self-assembly mediates the flocculation activity of benzimidazole derivatives against E. coli.

Bacterial flocculation is a process in which bacteria aggregate to form cloudy, flake-like clusters known as flocs. While this phenomenon is commonly associated with water treatment, it also has interesting industrial applications, particularly as a method for cell immobilisation. Escherichia coli, extensively employed in industrial processes, typically does not possess inherent flocculation ability.

Nitroxide-Modified Silica Nanoparticles: Impact of Radical Density on Relaxometric and EPR Properties.

In this study, we report the synthesis and characterization of nitroxide-functionalized silica nanoparticles incorporating a TEMPO-based spin label. These nanoparticles were prepared through a reverse microemulsion method, and the nitroxide moiety was introduced via a TEMPO-modified silane, synthesized by coupling 4-amino-TEMPO with 3-(triethoxysilyl)propylsuccinic anhydride. By adjusting experimental parameters, we successfully modulated the radical surface density, obtaining values ranging from 0.

Rapid Dereplication of Trunk Bark Constituents of and Molecular Docking of Terpenoids from Three Congolese Species.

Phytochemical investigation and bioactivity evaluation of terpenoids from the species were conducted. The chemical composition of was explored using chemical phytochemical screening techniques and dereplication of C NMR data using MixONat software (v. 1.

Large-Scale Chromatography for the Isolation of 7S Globulin Enriched Fraction from Pigeon Pea Seeds.

Pigeon pea () contains around 60% globulin proteins, of which 7S globulin is the most abundant fraction. In this work, a purification protocol for pigeon pea 7S globulin was developed using large-scale chromatography. The process was designed on an analytical scale through desalting of the crude protein extract followed by anion exchange chromatography and size exclusion chromatography.

Antiradical and anti-acethylcholinesterase constituents from the methylene chloride extract of (Pers.) Pat (Ganodermataceae) and molecular docking study.

Alzheimer's disease (AD) is a non-communicable disease with global impact. Inhibitors of acetylcholinesterase (AChE) are suitable therapies for AD. In this work, we report the isolation of antiacetylcholinesterase compounds from the methylene chloride (DCM) extract of the medical fungus (Pers.

Unlocking the Potential of Mg-Doped Rare Earth Manganites: Machine Learning-Guided Synthesis and Insights into Structural and Optical Properties.

By leveraging machine learning insights from prior perovskite studies and employing the sol-gel method, we successfully synthesized two novel perovskite nanoceramics-M CaMgMnO (M = La, Pr)-as multifunctional nanomaterials. X-ray diffraction (XRD) confirmed their orthorhombic Pnma crystal structure. The Williamson-Hall method estimated average particle sizes of 59.

Therapeutic Approaches with Iron Oxide Nanoparticles to Induce Ferroptosis and Overcome Radioresistance in Cancers.

The emergence of nanotechnology in medicine, particularly using iron oxide nanoparticles (IONPs), may impact cancer treatment strategies. IONPs exhibit unique properties, such as superparamagnetism, biocompatibility, and ease of surface modification, making them ideal candidates for imaging, and therapeutic interventions. Their application in targeted drug delivery, especially with traditional chemotherapeutic agents like cisplatin, has shown potential in overcoming limitations such as low bioavailability and systemic toxicity of chemotherapies.

Securidacaxanthone D: a new xanthone with free radical scavenging activity from the roots of (Polygalaceae).

A previously unpublished xanthone named securidacaxanthone D () and five known analogues: 1,7-dihydroxyxanthone (), 7-hydroxy-1,2-dimethoxy-xanthone (), 1,5-dihydroxy-6,7-dimethoxyxanthone (), 1,7-dihydroxy-3-methoxyxanthone (), 1,7-dihydroxy-4-methxyxanthone () were isolated from the ethyl acetate soluble fraction obtained from the liquid-liquid partition of the crude hydro-ethanolic extract of the roots of . Their structures were determined by analysis of 1D -(H and C), 2D-(COSY, HSQC and HMBC) NMR data in conjunction with mass spectrometry (TOF-ESI-MS) and by comparison with reported data. Free radical scavenging activity were evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) as a free radical.

Digestive fate of emulsions formulated with pea and lupin protein ingredients: Modulation of lipid digestibility and bioaccessibility by the interfacial composition?

Pea and lupin protein ingredients are suitable sources to promote the transition towards more plant proteins in foods, as they display promising nutritional and emulsifying properties. Oil-in-water emulsions (10 wt% oil, 2.5 g proteins/L) were prepared with pea and lupin protein isolates and concentrates.

Tailoring Nanodiamonds for High-Contrast EPR Imaging: Size, Surface Properties, and Spectroscopic Performance.

Electron paramagnetic resonance (EPR) spectroscopy is a tool that provides sensitive detection of uncoupled electron spins for a variety of applications. This technique enables the specific detection and quantification of radical species while also being able of generating high-contrast, background-free images. However, the EPR labeling and imaging techniques encounter limitations mainly due to the instability of organic radicals from organic probes, which can influence the reliability and scope of the experiment.

Constituents, Nutrient Content, and In Vitro Antioxidant and Anti-Inflammatory Activity of Tricholomopsis aurea (Agaricomycetes) from Cameroon.

Tricholomopsis aurea is used as food in different parts of the world, but has not been investigated for its nutrients, metabolites, and biological potentials like other edible mushrooms. This work aimed to quantify the metabolic and nutrient content of T. aurea and evaluate the antioxidant and anti-inflammatory activities of the extract and isolated compounds.

Spacer engineering in nanoparticle-peptide conjugates boosts targeting specificity for tumor-associated antigens.

Developing and synthesizing nano-objects capable of enabling early targeted diagnosis and ensuring effective tumor treatment represents a significant challenge in the theranostic field. Among various nanoparticles (NPs), iron oxide nanoparticles (IONPs) have made significant contributions to advancing this field. However, a key challenge lies in achieving selective recognition of specific cell types.

Chemical constituents and antibacterial activities of Cameroonian dark brown propolis against potential biofilm-forming bacteria.

Propolis is a resinous material collected by different bee species from various plant exudates and used to seal holes in honeycombs, smoothen the internal walls, embalm intruders, improve health and prevent diseases. From its -hexane extract, eight compounds were isolated and characterised as: mangiferonic acid (); 1-hydroxymangiferonic acid (), new natural product; mangiferolic acid(); 27-hydroxymangiferolic acid (), reported here for the first time as propolis constituent; 27-hydroxymangiferonic acid (); -amyrin (); -amyrin () and lupeol (). The chemical structures of the isolated compounds were elucidated using spectroscopic methods, such as 1D and 2D-NMR, mass spectrometry and comparison with previous published reports.

Gadopiclenol: A q = 2 Gadolinium-Based MRI Contrast Agent Combining High Stability and Efficacy.

Objectives: Gadopiclenol is a q = 2 pyclen gadolinium-based contrast agent (GBCA) recently approved by the Food and Drug Administration, European Medicines Agency, and other European countries. The aim of this report is to demonstrate its stability in multiple stressed in vitro conditions and in vivo, in rat kidney, while maintaining its higher relaxivity compared with conventional GBCAs on the market.

Materials And Methods: Both gadopiclenol and its chemical precursor Pi828-Gd were characterized and compared with q = 1 gadolinium (Gd) complexes.

Kerstinginone, a new flavanone derivative from Commiphora kerstingii Engl. (Burseraceae) with potent apoptosis-inducing activity and inhibition of AKT/mTOR signaling pathway in non-sensitive prostate cancer cells.

Ethnopharmacological Relevance: Commiphora kerstingii Engl is a tree which is 20-30 m in height and commonly called "ararrabi" in Hausa. It is found in the Sahelian region (Cameroon, Chad, and Nigeria) where it is utilized for the treatment of several ailments including cancer.

Aim Of The Study: This study was aimed at investigating the chemical constituents and cytotoxic effect of extracts and isolates from the stem barks and leaves of C.

Defects or no defects? Or how to design 20-25 nm spherical iron oxide nanoparticles to harness both magnetic hyperthermia and photothermia.

Designing iron oxide nanoparticles (IONPs) to effectively combine magnetic hyperthermia (MH) and photothermia (PTT) in one IONP formulation presents a significant challenge to ensure a multimodal therapy allowing the adaptation of the treatment to each patient. Recent research has highlighted the influence of factors such as the size, shape, and amount of defects on both therapeutic approaches. In this study, 20-25 nm spherical IONPs with a spinel composition were synthesized by adapting the protocol of the thermal decomposition method to control the amount of defects.

Bifunctional Hexadentate Pyclen-Based Chelating Agent for Mild Radiofluorination in Aqueous Solution at Room Temperature with a Ga-F Ternary Complex.

Positron Emission Tomography (PET) is used in oncology for tumor diagnosis, commonly relying on fluorine-18 (F) emission detection. The conventional method of F incorporation on to probes by covalent bonding is harsh for sensitive biomolecules, which are nonetheless compounds of choice for the development of targeted probes. This study explores gallium-F (GaF) coordination, a milder alternative method occurring in aqueous media at the final stage of radiosyntheses.

Flavonoid glycosides from leaves.

(Acanthaceae) leave extract was investigated for its flavonoid content. Column chromatography was used for compound isolation and mass spectrometry was performed using electrospray ionization (ESI) in the negative ion mode for compound identification. The full characterization of luteolin 7--[β-D-apiofuranosyl-(1 → 2)--β-D-ribofuranoside], a flavone glycoside, was achieved using tandem mass spectrometry and high resolution 1D and 2D Nuclear Magnetic Resonance (NMR).

Myxaoside A, a new triterpenoid saponin from L. (Boraginaceae).

The phytochemical study of L. led to the isolation, through chromatographic techniques, of a new triterpenoid saponin, 3--[--rhamnopyranosyl-(1→3)-(6--acetyl---glucopyranosyl)]-22-hydroxyolean-12-ene () namely Myxaoside A, together with three known compounds, Soyasaponine I (), oleanolic acid (), and 3--acetyl-oleanolic acid (). All structures were established, based on 1 & 2D-NMR spectroscopic analysis and comparison with previous published reports.

A Review on the Design of Carbon-Based Nanomaterials as MRI Contrast Agents.

The administration of magnetic resonance imaging (MRI) contrast agents (CAs) has been conducted since 1988 by clinicians to enhance the clarity and interpretability of MR images. CAs based on gadolinium chelates are the clinical standard used worldwide for the diagnosis of various pathologies, such as the detection of brain lesions, the visualization of blood vessels, and the assessment of soft tissue disorders. However, due to ongoing concerns associated with the safety of gadolinium-based contrast agents, considerable efforts have been directed towards developing contrast agents with better relaxivities, reduced toxicity, and eventually combined therapeutic modalities.