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Article Abstract
A previously unpublished xanthone named securidacaxanthone D () and five known analogues: 1,7-dihydroxyxanthone (), 7-hydroxy-1,2-dimethoxy-xanthone (), 1,5-dihydroxy-6,7-dimethoxyxanthone (), 1,7-dihydroxy-3-methoxyxanthone (), 1,7-dihydroxy-4-methxyxanthone () were isolated from the ethyl acetate soluble fraction obtained from the liquid-liquid partition of the crude hydro-ethanolic extract of the roots of . Their structures were determined by analysis of 1D -(H and C), 2D-(COSY, HSQC and HMBC) NMR data in conjunction with mass spectrometry (TOF-ESI-MS) and by comparison with reported data. Free radical scavenging activity were evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) as a free radical. Crude extract, ethyl acetate and -butanol fractions as well as isolated compounds showed different degrees of free radical scavenging activity. Among the extract and fractions tested, the hydro-ethanolic extract was the most active with an IC value of 32 μg/mL. Among the compounds, compound was the most active with an IC value of 282 μg/mL.
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| http://dx.doi.org/10.1080/14786419.2025.2484268 | DOI Listing |
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