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http://dx.doi.org/10.1007/s00405-025-09531-5 | DOI Listing |
Eur Arch Otorhinolaryngol
August 2025
Department of 'Organi di Senso', University "Sapienza", Viale dell'Università 33, Rome, 00185, Italy.
Catheter Cardiovasc Interv
July 2025
Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
Severe aortic regurgitation (AR) for a leaflet malfunction after transcatheter aortic valve implantation (TAVI) is a dreadful complication that can lead even to cardiogenic shock. New valve's design has reduced the rate of paravalvular regurgitation, however central regurgitation is still a challenging complication. An 88-year-old woman with severe aortic stenosis underwent TAVI with an Edwards Sapien III valve.
View Article and Find Full Text PDFJACC Case Rep
April 2025
Department of Structural Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Objective: The authors describe a transcatheter mitral valve-in-valve-in-valve (VIVIV) for the correction of a degenerated transcatheter in a surgical bioprosthesis, a challenging interventional scenario that will be increasingly frequent in the near future.
Key Steps: The key steps taken were as follows: preprocedural planning integrating data from transesophageal echocardiogram, cardiac computed tomography, and 3mensio reconstruction (Pie Medical Imaging); transfemoral transseptal VIVIV performed with EchoNavigator system (Philips) guidance; Sapien Ultra 3 26-mm valve (Edwards Lifesciences) delivered with buddy balloon maneuvers to uncage the valve from the atrial struts of the previously implanted valve; and atrial septal defect occlusion with the Amplatzer ASO 24 mm (Abbott Cardiovascular).
Potential Pitfalls: The inability to advance the prosthesis into the ventricle, irreversible hemodynamic collapse, residual high transmitral mean gradient because of impingment of the 3 valves, residual paravalvular leaks, and left ventricular outflow tract obstruction.
BMC Bioinformatics
March 2025
Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, V5Z 4S6, Canada.
Background: Advanced long-read sequencing technologies, such as those from Oxford Nanopore Technologies and Pacific Biosciences, are finding a wide use in de novo genome sequencing projects. However, long reads typically have higher error rates relative to short reads. If left unaddressed, subsequent genome assemblies may exhibit high base error rates that compromise the reliability of downstream analysis.
View Article and Find Full Text PDFMicrob Biotechnol
February 2025
Department of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Institute for Health Research, Area of Biology and Evolution of Microorganisms and Epidemiology and Public Health Networking Biomedical Research Centre (CIBERESP), Madrid, Spain.
Microbes constitute a ubiquitous warp, a highly sensitive skin of the biosphere that can be scratched and damaged by all human activities. However, the existence of life in general and the human species, in particular, depends on the intelligent preservation of such a biological microbiological cement linking our health with the health of Earth. We are responsible for maintaining sustainable health by managing our damaging individual and social behaviour, and we are also charged with the duty of correcting the microbial disequilibrium we are provoking.
View Article and Find Full Text PDF