Accuracy and Clinical Findings of Saliva Digestive Biomarkers in Laryngopharyngeal Reflux Disease.

Objective: To evaluate the diagnostic performance of multiple digestive enzyme biomarkers in detecting and characterizing laryngopharyngeal reflux disease (LPRD).

Methods: Patients with LPRD at the 24-h hypopharyngeal-esophageal multichannel intraluminal impedance-pH testing (HEMII-pH) were consecutively recruited from January 2020 to May 2024 from two European hospitals. The control group consisted of adults without symptoms.