Publications by authors named "Luigi A Vaira"

this pilot study aimed to evaluate the diagnostic accuracy of ChatGPT-4o in analyzing oral mucosal lesions from clinical images. : a total of 110 clinical images, including 100 pathological lesions and 10 healthy mucosal images, were retrieved from Google Images and analyzed by ChatGPT-4o using a standardized prompt. An expert panel of five clinicians established a reference diagnosis, categorizing lesions as benign or malignant.

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: The aim of our study was to evaluate clinical outcomes in patients with small pleomorphic adenoma (PA) after extracapsular dissection (ED) versus superficial parotidectomy (SP). : Following the PRISMA guidelines, a systematic review covering the years from 1950 to 2025 was conducted using the Pubmed/MEDLINE, Cochrane Library, Scopus, Ovid MEDLINE and Embase databases. A single-arm meta-analysis was performed to evaluate intraoperative capsular rupture, recurrence, transient and permanent facial nerve palsy, Frey's syndrome, salivary fistula, seroma and hematoma of patients who underwent ED vs.

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Aim: This retrospective study evaluated whether the timing of dietary progression after mandibular fracture repair influences postoperative complications (wound dehiscence, infection, and reoperation) and assessed how comorbidities, specifically diabetes and chronic kidney disease (CKD), affect these outcomes.

Methods: A retrospective observational analysis was conducted of 1023 patients who underwent open reduction and internal fixation (ORIF) for mandibular fractures between 2012 and 2023. Patients were categorised into Early (<3 weeks), Standard (3 weeks), and Delayed (>4 weeks) groups according to the interval before the introduction of a solid diet.

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Purpose: Smokers with squamous cell carcinoma (SCC) of the tongue may be particularly prone to experience multifactorial gustatory dysfunction. This study investigates the effects of heavy smoking on taste perception in patients undergoing glossectomy type IIIa (i.e.

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BackgroundMicroaggressions are subtle verbal or behavioral insults (intentional or unintentional) that typically convey negative or hostile attitudes towards marginalized groups. We aim to study microaggressions and workplace culture amongst European otolaryngologist -head and neck surgeons (E-OTOHNS). The perception of "differential treatment" based on individual traits was used as a proxy for microaggressions.

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Importance: The incidence of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) arising from the palatine tonsil and base of the tongue (BOT) is increasing among the older population. However, data on the prognostic impact of HPV status in patients 70 years and older who undergo up-front surgical treatment remain limited.

Objective: To evaluate whether HPV status is associated with survival outcomes in patients 70 years or older undergoing surgical treatment for squamous cell carcinoma (SCC) of the tonsil or BOT.

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Objective: To investigate the demographic determinants of patient perception toward the role of artificial intelligence (AI) in otolaryngology-head and neck surgery care.

Methods: Outpatients consulting in otolaryngology-head and neck surgery departments of 18 hospitals were surveyed about the perception of the role of AI in health care. The results were analyzed according to the age, gender, patient use of technology, and the level of education.

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Ectrodactyly-ectodermal dysplasia-cleft (EEC) syndrome is a rare genetic disorder presenting significant challenges for dental rehabilitation due to severe maxillary atrophy and altered anatomy. This report describes a 23-year-old female with EEC syndrome successfully rehabilitated using a custom-made subperiosteal implant. Despite multiple grafting procedures, conventional implants were not viable.

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Epistaxis is a common cause of consultation in otolaryngology, manifesting either as isolated episodes or recurrent events. In this paper, we report the history of an 8-year-old African male who presented with periodic epistaxis temporally associated with joint inflammation. The diagnostic work-up, supported by artificial intelligence-based clinical decision support, led to the diagnosis of rheumatic fever.

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This systematic review and meta-analysis evaluates the surgical, functional, and aesthetic outcomes of scapular free flaps in maxillary reconstruction. The primary objective is to assess early surgical complications, fistula formation, donor site morbidity, dental restoration, normal dietary intake, aesthetic compromise, and eye-related issues. Secondary objectives include total free flap necrosis, the need for revision procedures, and functional performance of the upper limb.

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Purpose: Trauma is a common cause of facial nerve palsy, accounting for 3% of all cases. While many facial palsies resolve with medical treatment, some require surgical intervention. This systematic review aimed to determine the best therapeutic strategy for traumatic facial palsy.

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: Anterior disc displacement without reduction (ADDwoR) of the temporomandibular joint (TMJ) often leads to persistent pain and reduced quality of life (QoL). Conservative treatments frequently fail to provide adequate symptom relief. : To assess the short-term (≥6 months) effectiveness of functional arthroplasty in reducing pain and improving QoL in patients with ADDwoR unresponsive to conservative therapies.

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TAS2R38 is the T2R receptor primarily associated with the innate immune response of the respiratory system. It activates a response mediated by nitric oxide (NO), which has been shown to inhibit the replication of SARS-CoV-2. TAS2R38 polymorphisms (SNPs) that decrease receptor functionality contributing to individual differences in susceptibility to airway infections.

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Background: Total maxillectomy for malignant tumors presents significant challenges for functional and aesthetic rehabilitation. Advances in digital planning and additive manufacturing have reintroduced subperiosteal implants as a promising solution for primary reconstructions.

Case Report: This report details the case of a 59-year-old male with squamous cell carcinoma of the hard palate extending contralaterally, treated with a total maxillectomy and primary reconstruction using an osteomyocutaneous fibula free flap combined with a custom-made, additively manufactured subperiosteal implant.

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Introduction: Chatbot Generative Pretrained Transformer (ChatGPT), a multimodal generative AI, has been studied for potential applications in healthcare, including otolaryngology-head and neck surgery. In this study, authors investigates the consistency of ChatGPT-4o in analyzing clinical fiberoptic videos of suspected laryngeal malignancies compared to expert clinicians.

Methods: This experimental study involved twenty patients with primary laryngeal disease consulting at a tertiary academic center.

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Objectives: Large language models (LLMs) show promise in clinical decision-making, but comparative evaluations of their antibiotic prescribing accuracy are limited. This study assesses the performance of various LLMs in recommending antibiotic treatments across diverse clinical scenarios.

Methods: Fourteen LLMs, including standard and premium versions of ChatGPT, Claude, Copilot, Gemini, Le Chat, Grok, Perplexity, and Pi.

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Objective: To explore the excitability and sensory motor integration of the face and masticatory primary motor cortex (M1), and recognition of face expressions in individuals with dentofacial deformities (IDD).

Methods: Short-interval intracortical inhibition (SICI), short-afferent inhibition (SAI) of masticatory and face M1, the blink reflex and face expressions recognition (FER) ability were assessed in 18 healthy subjects (HS) (24.56 ± 1.

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Severe atrophy in isolated posterior maxillary sectors poses challenges for dental rehabilitation, especially in partially dentate patients where traditional graftless techniques are unsuitable. This study retrospectively analyzed the outcomes of sectional rehabilitation in 16 consecutive patients with Cawood and Howell class V to VI atrophy treated with 21 custom fabricated subperiosteal implants. Patients were followed for a median of 36 months (interquartile range: 24 to 48).

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