Salivary Pepsin Measurement in Laryngopharyngeal Reflux Disease: A Systematic Review of Diagnostic Accuracy and Performance.

Objective: To analyze the methods used for digestive enzyme measurements in saliva of patients with laryngopharyngeal reflux disease (LPRD) and to investigate their respective diagnostic performances.

Methods: Three independent investigators conducted a PubMED, Scopus, and Cochrane Library database search for studies investigating the digestive saliva enzyme measurements in LPRD patients according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements.

Results: Of the 183 screened studies, 38 studies met the inclusion criteria (1461 females (47.