Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression.

Protein phosphorylation modification plays an important role in regulating protein activity. Astrocyte elevated gene-1 (AEG-1), an adaptor protein, promotes the progression of various types of cancers by protein-protein interactions. We previously demonstrated that AEG-1 promoted the growth and metastasis of gastric cancer by upregulating the expression of oncogenic eukaryotic translation initiation factor 4E (eIF4E).

Advances in Research on Monogenic Hereditary Hypertension.

Hypertension is one of the most significant preventable health risk factors globally. Among its various forms, monogenic hypertension, although rare, warrants attention. As awareness of monogenic hypertension grows within both the public and medical communities, research efforts are intensifying.

The association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) index and obesity in postmenopausal women: a cross-sectional analysis based on the NHANES.

Background: Obesity has emerged as a critical global public health challenge. Postmenopausal women experience significantly elevated risks of metabolic disorders and a marked increase in obesity prevalence due to declining estrogen levels. The uric acid to high-density lipoprotein cholesterol ratio (UHR), an emerging biomarker for metabolic syndrome, is gaining clinical recognition.

Exosomal miR-494 from Bone Marrow Mesenchymal Stem Cells Attenuates Ferroptosis and Enhances Spinal Cord Injury Repair by Modulating the SIRT1/HO-1 Pathway.

Spinal cord injury (SCI) is a severe traumatic disorder of the central nervous system, often resulting in partial or complete loss of sensory and motor functions. Ferroptosis, a lipid peroxidation-driven apoptotic process triggered by iron overload, has emerged as a novel form of programmed cell death and a focal point in post-SCI cell death research. Exosomes (Exo), as delivery vehicles, exhibit multiple advantages, including superior encapsulation capacity, high targeting efficiency, and enhanced blood-brain barrier penetration to reach the central nervous system.

Hydrogel adhesives with a hydrodynamically induced liquid-solid transition for annular fissure sealing and inflammation modulation following microdiscectomy.

Background: Intervertebral disc (IVD) herniation is a major cause of low back pain and disability, with microdiscectomy being the standard surgical treatment. However, microdiscectomy fails to address annulus fibrosus (AF) defects, increasing the risk of recurrent herniation. Current therapeutic strategies for this condition remain limited in efficacy.

Sono-Controllable Janus Hydrogel Platform for Sequential Tumor Eradication and Bone Regeneration in Metastatic Breast Cancer.

Bone metastases occur in 60%-75% of patients with metastatic breast cancer, reducing survival rates and compromising quality of life. Innovative treatments are urgently needed to sequentially eradicate tumor cells and promote bone regeneration. In this study, a novel Janus hydrogel platform (GA@CaMP) is developed for encapsulating the sonosensitive composite nanomaterial MHP, which enables gene expression regulation, along with oxygen-releasing CaO NPs.

A Novel Morphological Classification to Guide Transcatheter Mitral Valve Edge-to-Edge Repair for Commissural Mitral Regurgitation.

Background: Mitral commissural prolapse poses significant anatomical challenges that can hinder the effectiveness of transcatheter edge-to-edge repair (TEER).

Objectives: The aim of this study was to estimate the safety and effectiveness of applying a novel morphological classification to guide TEER in patients with commissural degenerative mitral regurgitation (DMR).

Methods: In this prospective, multicenter study across 18 centers in China, we classified patients with severe commissural DMR into 4 morphological types through detailed echocardiographic analysis.

Ubiquitously expressed transcript isoform 2 (UXT-V2) restricts HSV-2 replication by targeting glycoprotein B for degradation through ubiquitin-proteasome pathway.

Herpes simplex virus 2 (HSV-2) is a major pathogen causing neonatal herpes and increasing the risk of human immunodeficiency virus 1 (HIV-1) infection. However, the mechanisms underlying host restriction of HSV-2 infection are still not fully understood. The ubiquitously expressed transcript isoform 2 (UXT-V2), an α-type prefoldin protein, functions as a versatile transcription factor associated with numerous human tumors, but its role in viral infection remains unclear.

Effect of radical radiotherapy dose on the prognosis of limited-stage thoracic small cell carcinoma of the esophagus: A multicenter retrospective trial from China (CHiSCEC).

Background: The optimal radiation dose for the treatment of small cell carcinoma of the esophagus (SCEC) has not been established. This study aimed to investigate the treatment outcomes and toxicities in patients with limited-stage SCEC (LS-SCEC) treated by radiotherapy.

Methods: Patients with LS-SCEC from 14 institutions were retrospectively identified between December 2000 and October 2021.

Recent Advances of Aggregation-Induced Emission Luminogens in Atherosclerotic Cardiovascular Disease.

Atherosclerotic cardiovascular disease (ASCVD), the primary cause of mortality worldwide, is distinguished by the development of atherosclerotic plaques due to lipid accumulation in the artery wall, ultimately resulting in a range of severe cardiovascular and cerebrovascular complications. In recent years, aggregation-induced emission luminogens (AIEgens), which possess the advantages of fluorescence enhancement in aggregated states, exceptional photostability, and finely tunable biocompatibility, have emerged as a promising candidate for the diagnosis and treatment of ASCVD. This review systematically summarizes the research advancements of AIEgens in ASCVD over the past five years, mainly including the properties of AIEgens and the design for ASCVD management, the application of AIEgens in ASCVD biomarkers sensing, imaging and treatment of ASCVD.

Assessment of docosahexaenoic acid's preventive efficacy against unconjugated bilirubin neurotoxicity through MRP1 protein expression.

Objective: Jaundice in neonates promotes unconjugated hyperbilirubinemia (UCB), which causes neurological disorders, and its management remains a challenge. This study evaluated the protective effect of docosahexaenoic acid (DHA) against UCB-induced neurotoxicity.

Method: Astrocyte cell lines were prepared and separated into four different groups: SAL group; DHA group treated with 50 µM DHA; UCB group treated with 50 µM UCB; and UCB + DHA group treated with 50 µM UCB along with 50 µM DHA.

Safety of fruquintinib in Chinese patients with colorectal cancer: an age subgroup analysis from a phase IV real-world clinical practice study.

Background: Colorectal cancer (CRC) is increasingly prevalent among young adults (<50 years) in China, a demographic that has been historically underrepresented in clinical studies. While most patients with CRC are aged ⩾65 years, this age group is also underrepresented in trials, highlighting the need for a better understanding of treatment outcomes in both younger and older populations. A recent phase IV trial evaluating the safety of fruquintinib in Chinese patients with metastatic CRC (mCRC) showed a manageable profile.

MRI-based deep learning radiomics in predicting histological differentiation of oropharyngeal cancer: a multicenter cohort study.

Background: The primary aim of this research was to create and rigorously assess a deep learning radiomics (DLR) framework utilizing magnetic resonance imaging (MRI) to forecast the histological differentiation grades of oropharyngeal cancer.

Methods: This retrospective analysis encompassed 122 patients diagnosed with oropharyngeal cancer across three medical institutions in China. The participants were divided at random into two groups: a training cohort comprising 85 individuals and a test cohort of 37.

Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma.

Tumors evolve to avoid immune destruction and establish an immunosuppressive microenvironment. Syngeneic mouse tumor models are critical for understanding tumor immune evasion and testing cancer immunotherapy. Derived from established mouse tumor cell lines that can already evade the immune system, these models cannot simulate early phases of immunoediting during initial tumorigenesis.

Effects of standardised patients (SP) combined with case-based learning (CBL) in Chinese clinical education: a systematic review and meta-analysis.

Objectives: Combining standardised patients (SP) with case-based learning (CBL) enriches the learning experience by immersing learners in diverse clinical scenarios. This meta-analysis study aims to assess the intervention effects of this teaching approach on Chinese medical students' and resident physicians' teaching satisfaction, theoretical knowledge achievements and clinical practice performance.

Design: A systematic review and meta-analysis through Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 statement.

Mechanisms of podophyllotoxin-induced enterotoxicity: A multi-omics integration of gut microbiota, short-chain fatty acids, and inflammatory mediators.

Podophyllotoxin (PPT), a lignan extracted from the roots and stems of Podophyllum species, exhibits significant enterotoxicity that limits its clinical application. However, its underlying mechanisms remain unclear. This study aimed to elucidate the mechanisms underlying PPT-induced enterotoxicity.

China Expert consensus on the application of metagenomic next-generation sequencing for the etiological diagnosis of infections in hematological disorders (2024).

Infections are frequent complications in patients with hematological disorders, and pathogen diagnosis remains challenging. Metagenomic next-generation sequencing (mNGS) is an unbiased high-throughput technology that has been widely applied in the diagnosis of infectious diseases. However, to date, there are no established international guidelines or expert consensuses regarding the use of mNGS to diagnose infections in patients with hematologic disorders.

A combined model integrating deep learning, radiomics, and clinical ultrasound features for predicting mutation in papillary thyroid carcinoma with Hashimoto's thyroiditis.

Objective: This study aims to develop an integrated model that combines radiomics, deep learning features, and clinical and ultrasound characteristics for predicting mutations in patients with papillary thyroid carcinoma (PTC) combined with Hashimoto's thyroiditis (HT).

Methods: This retrospective study included 717 thyroid nodules from 672 patients with PTC combined with HT from four hospitals in China. Deep learning and radiomics were employed to extract deep learning and radiomics features from ultrasound images.

Evaluating the operational efficiency of the compact urban medical group in Qiqihar based on the three-stage DEA and Malmquist index model.

Background: Since the establishment of medical alliances, a key issue regarding their ability to better address the imbalance in China's medical resources lies in the changes in operational efficiency before and after their formation. This study focuses on urban medical groups, a reform model of medical alliances, and systematically analyzes the changes in operational efficiency before and after the group-based reform, aiming to provide empirical evidence for improving the group-based management model.

Methods: This study employs a dual-method framework combining three-stage DEA for static efficiency evaluation and Malmquist index analysis for dynamic assessment.

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma.

Lung squamous cell carcinoma (LUSC) remains a lethal malignancy with limited therapeutic advancements, underscoring the need to identify novel oncogenic drivers. This study integrates multi-omics analyses-including ChIP-seq, bulk RNA-seq, single-cell ATAC/RNA-seq, and spatial transcriptomics-to delineate enhancer-driven transcriptional networks in 59 matched LUSC tumors and adjacent normal tissues. The analyses identify 3,447 tumor-specific oncogenic enhancers (SOEs) enriched for master transcription factors (SOX2, TP63, KLF5, GRHL2) that orchestrate malignant programs.

Research Progress on Histone Lactylation Modification in Ischemic Stroke: Mechanisms and Therapeutic Potential.

Ischemic stroke (IS) is a leading cause of death and disability worldwide, with a complex pathogenesis involving neuroinflammation, oxidative stress, and disruption of the blood-brain barrier. Recent research has brought histone lactylation into focus as a novel epigenetic modification that plays a crucial role in IS. Under cerebral ischemia and hypoxia, lactate levels rise, providing an alternative energy source to support ischemic brain regions.

SLC16A3 as an immunosuppressive Kupffer cell marker predicts poor prognosis in HBV-positive hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is one of the malignant tumors that currently pose a significant threat to human health, with infection by hepatitis B virus (HBV) being a critical risk factor for the development of HCC. It is critical to identify potential molecular targets affecting HBV-positive HCC patients.

Methods: In this study, we comprehensively utilized single-cell sequencing and external transcriptome sequencing databases to further analyze the mechanism of SLC16A3's influence on liver cancer and its microenvironment under different HBV status.

Projecting Global Trends and Inequalities in Adult Overweight and Obesity, 2023-2040: Findings From the NCD-RisC Database.

Objective: This study quantifies the global burden of overweight and obesity, projects future trends, and examines associated health inequalities.

Methods: Overweight and obesity burden data were obtained from the NCD-RisC database. Trends from 1990 to 2022 were analyzed, and a Bayesian model was used to project changes for 2023-2040.